2008
DOI: 10.1002/adsc.200800596
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Abstract: High-throughput screening offers major opportunities to accelerate the discovery and optimization of homogeneously catalyzed reactions. A general method for acquisition of reaction profiles through a high-throughput quenching (HTQ) approach is described, which gives a more accurate picture of catalyst performance, e.g., total productivity, induction periods, selectivity and lifetime, than the customary analysis at a fixed, arbitrary time.

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Cited by 26 publications
(29 citation statements)
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“…Therefore, it is important to examine and understand trends in relative catalyst efficiencies based on both reaction conditions and substrate design. With this in mind, the performance of several commercially available catalysts along with recently reported variants were utilized in this study (Figure 1), reaffirming the notion that no single catalyst is best for all olefin metathesis applications 1f, 6c, 6d…”
supporting
confidence: 76%
See 1 more Smart Citation
“…Therefore, it is important to examine and understand trends in relative catalyst efficiencies based on both reaction conditions and substrate design. With this in mind, the performance of several commercially available catalysts along with recently reported variants were utilized in this study (Figure 1), reaffirming the notion that no single catalyst is best for all olefin metathesis applications 1f, 6c, 6d…”
supporting
confidence: 76%
“…More recently, decreasing N-aryl steric bulk ( 7 and 8 ) on the N-heterocyclic carbene (NHC) and adding methyl-groups to the backbone ( 9 and 10 ) have greatly increased activity and stability, allowing for efficient synthesis of highly hindered olefin products. 5d,e, 6…”
mentioning
confidence: 99%
“…For systems in the liquid phase, Fogg and colleagues noted that "For the present, the most reliable means of obtaining time-resolved insight is via a "high-throughput quenching" methodology ( Figure 9.22), in which a 96-well plate is converted into a smaller series of time-arrayed experimental sets" (Blacquiere et al, 2008;Monfette et al, 2011). This becomes an array of single-point experiments.…”
Section: Designs For Determination Of Kinetic Parametersmentioning
confidence: 98%
“…Unlike EVE, CO, and D1,c ompound II satisfies all requirements for an ideal quenching agent for OM, as proposed by Fogg et al [70] The only notable drawback is the fact that it forms ad istinct peak in GC analysis, whichc an overlap with product and/ors ubstrate peaks. In the event of such ac oincidence, changing the column or adjustingt he thermalp rogram should be sufficient to obtain usable data.…”
Section: Evaluation Of II As Aq Uenchinga Gentmentioning
confidence: 99%
“…Furthermore, they enablet he high-throughput acquisition of reaction profilesw ithoutt he need for real-time, online, parallel analytics,w hichw ould require expensive hardware. [70] Fogg et al proposed the following set of traits desirable in aq uenching agent: [70] 1) complete interruption of all activity;2 )stability against decomposition into species that may cause furthero rganic reactions under the conditions required for the completion of analysis; 3) solubility in commono rganic solvents to facilitate robotic dispensing; 4) al ack of volatility at the reaction temperature;5 )fast and irreversible action;6 )effectiveness at low loadings to minimize interference with analysis;a nd 7) commercial availability or simple, cost-effective preparation.…”
Section: Evaluation Of II As Aq Uenchinga Gentmentioning
confidence: 99%