Applications of Co-Crystals in Pharmaceutical Drugs

Rekdal, Mikal; Pai, Aravind; Choudhari, Ravi; Sathyanarayana, Muddukrishna Badamane

doi:10.5530/srp.2018.1.11

Cited by 9 publications

(7 citation statements)

References 10 publications

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“…The task of improving tax administration requires, first of all, the systematization of regulatory and legal acts on taxes and other obligatory payments, which in turn influences the development of tax law. The main task of the tax administration is to identify and correct cases of tax evasion or tax evasion [23].…”

Section: Resultsmentioning

confidence: 99%

Matters of Improving Theological-Legal Basics of Tax Obligations

2020

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Section: Resultsmentioning

confidence: 99%

Matters of Improving Theological-Legal Basics of Tax Obligations

2020

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“…These NDDSs offer several advantages like improved solubility, enhanced drug absorption, increased bioavailability, reduced dose and side effects, controlled release, enhanced stability of bioactives inside body fluids, and improved therapeutic efficacy. 84 One of the interesting NDDSs is co-crystals, which can improve the solubility, absorption, and bioavailability of herbal bioactives. Co-crystals are a neutral multicomponent system, which consist of two components (drug and coformer).…”

Section: Co-crystals Of Herbal Bioactives For Solubility Enhancementmentioning

confidence: 99%

A Review on Co-crystals of Herbal Bioactives for Solubility Enhancement: Preparation Methods and Characterization Techniques

Rathi

Kaur

Singh

2022

Crystal Growth & Design

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Co-crystallization is a promising approach for improving physical and pharmacological properties of API, viz., solubility, dissolution rate, stability, hygroscopicity, tablet ability, mechanical properties, bioavailability, and therapeutic efficacy. Different methods for the preparation of pharmaceutical co-crystals have been discussed. Instrumental and physicochemical characterization methods have also been included. Herbal bioactives are potential candidates for co-crystallization to improve solubility, mask taste, and improve bioavailability. Literature on the development of co-crystals of herbal bioactives like curcumin, quercetin, berberine, resveratrol, naringenin, and miscellaneous herbal compounds has been reported systematically in the present review. In conclusion, co-crystallization of herbal bioactives is a promising method for enhancing their physical properties. However, toxicological, stability, regulatory, and scaleup issues must be adequately addressed before commercial viability can be expected.

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“…When compared to other solid-state manipulation methods of a drug such as complexation, solid dispersion, micellar solubilization, cosolvency, etc, co-crystals gained tremendous advantages due to their ease of preparation in the pharmaceutical field. 64,65 As per the guidelines of USFDA and EMA, all the co-crystals prepared by various coformers can be patented separately, though still there are unclearness lasts. In the recent years, a tremendous increase in the patent application of cocrystals has been found in WIPO patent database.…”

Section: Applications Of Co-crystals In Pharmaceutical Industrymentioning

confidence: 99%

Pharmaceutical Co-Crystallization: Regulatory Aspects, Design, Characterization, and Applications

et al. 2020

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Pharmaceutical co-crystals are novel class of pharmaceutical substances, which possess an apparent probability of advancement of polished physical properties offering stable and patentable solid forms. These multi-component crystalline forms influence pertinent physicochemical parameters like solubility, dissolution rate, chemical stability, physical stability, etc. which in turn result in the materials with superior properties to those of the free drug. Co-crystallization is a process by which the molecular interactions can be altered to optimize the drug properties. Co-crystals comprise a multicomponent system of active pharmaceutical ingredient (API) with a stoichiometric amount of a pharmaceutically acceptable coformer incorporated in the crystal lattice. By manufacturing pharmaceutical co-crystals, the physicochemical properties of a drug can be improved thus multicomponent crystalline materials have received renewed interest in the current scenario due to the easy administration in the pharmaceutical industry. There is an immense amount of literature available on co-crystals. However, there is a lack of an exhaustive review on a selection of coformers and regulations on co-crystals. The review has made an attempt to bridge this gap. The review also describes the methods used to prepare co-crystals with their characterization. Brief description on the pharmaceutical applications of co-crystals has also been incorporated here. Efforts are made to include reported works on co-crystals, which further help to understand the concept of co-crystals in depth.

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Applications of Co-Crystals in Pharmaceutical Drugs

Cited by 9 publications

References 10 publications

Matters of Improving Theological-Legal Basics of Tax Obligations

Matters of Improving Theological-Legal Basics of Tax Obligations

A Review on Co-crystals of Herbal Bioactives for Solubility Enhancement: Preparation Methods and Characterization Techniques

Pharmaceutical Co-Crystallization: Regulatory Aspects, Design, Characterization, and Applications

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