Applications of Cellulose and Cellulose Derivatives in Immediate Release Solid Dosage

A review of bioactive plant polysaccharides: Biological activities, functionalization, and biomedical applications

“…However, most polysaccharides do not show biological activity unless some modifications are carried out. Cellulose derivatives, such as methylcellulose, hydroxyethylcellulose, hydroxypropylcellulose, and hydroxylpropylmethylcellulose, have found promising applications in various fields such as food, medical, pharmaceutical, and cosmetics (Li & Mei, 2006). Therefore, further review of wood polysaccharides will be presented in the later functionalization/modification section.…”

“…corn and rice starch) are widely used as glidants, tablet disintegrants and binders, and capsule diluents (Marchessault et al, 2006). Numerous cellulose derivatives such as methyl cellulose, hydroxyethyl cellulose, hydroxypropyl cellulose, and hydroxylpropylmethyl cellulose, which often possess specific respond or even better physicochemical properties than cellulose have been applied in pharmaceutical applications (Francis, Piredda, & Winnik, 2006;Jain et al, 2014;Li & Mei, 2006;Marchessault et al, 2006). For example, phthalated hydroxypropylmethyl cellulose has excellent pH-dependent solubility, namely, stability in acidic conditions (at stomach) but soluble in mildly acidic to slightly alkaline solution and, therefore, has been developed for controlled intestinal targeting drug release systems (Kim, Park, Cheong, & Kim, 2003;Xu, Gao, Xu, Wu, & Sun, 2009).…”

Controlled release of drugs in electrosprayed nanoparticles for bone tissue engineering

“…EC can be used as a stabilizer, binder, water conserving agent and dispensing agent. In addition, it is used for sustained release of drugs [24]. growth, mineralization and differentiation by confirming it to be a possible candidate in bone tissue regeneration [25].…”

The Effect of the Physical States of Binders on High-Shear Wet Granulation and Granule Properties: A Mechanistic Approach Toward Understanding High-Shear Wet Granulation Process. Part II. Granulation and Granule Properties

“…The binder is a key component in wet granulation formulations and plays a critical role in the formation of granules 5–8. Polymers, including synthetic, semi‐synthetic and natural, are commonly used as wet granulation binders in the pharmaceutical industry 9, 10. It has been long recognized in the pharmaceutical industry that the method of binder incorporation is an important factor influencing granulation processes 11.…”