Applications of advanced hybrid organic–inorganic nanomaterials: from laboratory to market

Sánchez, Clément; Belleville, Philippe; Popall, Michael; Nicole, Lionel

doi:10.1039/c0cs00136h

Cited by 1,289 publications

(884 citation statements)

References 439 publications

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“…Recently, new emphasis has been placed on hybrid NP systems, where multiple nanomaterials are assembled to create multimodal systems that exhibit the combined qualities of the component modules (9)(10)(11). These constructs promise to integrate various functionalities by incorporating different nanomaterials into a single, efficient, multimodal system (12,13).…”

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confidence: 99%

Gold–silica quantum rattles for multimodal imaging and therapy

Hembury

Chiappini

Bertazzo

et al. 2015

Proc. Natl. Acad. Sci. U.S.A.

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110

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Gold quantum dots exhibit distinctive optical and magnetic behaviors compared with larger gold nanoparticles. However, their unfavorable interaction with living systems and lack of stability in aqueous solvents has so far prevented their adoption in biology and medicine. Here, a simple synthetic pathway integrates gold quantum dots within a mesoporous silica shell, alongside larger gold nanoparticles within the shell's central cavity. This "quantum rattle" structure is stable in aqueous solutions, does not elicit cell toxicity, preserves the attractive near-infrared photonics and paramagnetism of gold quantum dots, and enhances the drug-carrier performance of the silica shell. In vivo, the quantum rattles reduced tumor burden in a single course of photothermal therapy while coupling three complementary imaging modalities: near-infrared fluorescence, photoacoustic, and magnetic resonance imaging. The incorporation of gold within the quantum rattles significantly enhanced the drug-carrier performance of the silica shell. This innovative material design based on the mutually beneficial interaction of gold and silica introduces the use of gold quantum dots for imaging and therapeutic applications.nanomedicine | hybrid nanoparticle | cancer nanotechnology | gold quantum dots | mesoporous silica A lthough gold's potential in nanotechnology has been recognized for many decades (1, 2), new insights into the unique properties of gold nanoparticles (NPs) of less than 2 nm have just recently started to emerge (3, 4). Such extremely small gold NPs could be transformative for a broad set of applications ranging from energy production and storage to catalysis and health care (3). As the size of gold NPs decreases below 2 nm, the quantization of their conduction band leads to molecule-like properties (3). These quantum-sized gold NPs (or gold quantum dots, AuQDs) absorb light in the near-infrared (NIR) biological window (650-900 nm) (2) and convert it into photons and heat (5). Furthermore, whereas bulk gold is diamagnetic, some AuQDs exhibit magnetic properties (4, 6). However, the clear therapeutic and imaging potential of AuQDs in vivo has been undermined by their unfavorable biointeractions and lack of stability in aqueous solvents (5, 7). In biological environments AuQDs tend to aggregate rapidly, reverting to larger gold nanoparticles (AuNPs) (8) and/or bind to protein, which negatively affects their cytotoxicity (7). To retain their advantages, AuQDs require a protective, stabilizing framework that allows proficient biological interactions.Recently, new emphasis has been placed on hybrid NP systems, where multiple nanomaterials are assembled to create multimodal systems that exhibit the combined qualities of the component modules (9-11). These constructs promise to integrate various functionalities by incorporating different nanomaterials into a single, efficient, multimodal system (12, 13). However, these systems usually accumulate the specific functionalities of their component modules through multiple steps in their ...

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mentioning

confidence: 99%

Gold–silica quantum rattles for multimodal imaging and therapy

Hembury

Chiappini

Bertazzo

et al. 2015

Proc. Natl. Acad. Sci. U.S.A.

Self Cite

110

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“…The properties of the hybrid are governed by the individual contributions of both the organic and inorganic components, as well as the inner interfacial contributions. 75 Hybrids incorporating small organic lumophores have been extensively examined for the development of robust, lightemitting platforms 76 and attention has now turned towards the preparation of conjugated polymer based analogues. The incorporation of CPs into an inorganic matrix introduces multiple possibilities.…”

Section: Organic-inorganic Hybrid Cp Materialsmentioning

confidence: 99%

Harnessing self-assembly strategies for the rational design of conjugated polymer based materials

Evans

2013

J. Mater. Chem. C

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Targeted control of the aggregation, morphology and optoelectronic properties of conjugated polymers is critical for the development of high performance optoelectronic devices. In this Highlight, recent advances in the use of self-assembly approaches to strategically manipulate the order, conformation and spatial distribution of conjugated polymers in various states (e.g. solution, gels, films, solids) are discussed. Emphasis is placed on the complex relationship that exists between molecular composition, self-assembly and supramolecular organisation and their consequential influence on the optoelectronic properties and device performance.

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“…OC-I, an ORMOCER ® hybrid polymer developed by Fraunhofer ISC, was used as a photoresist (Fessel et al 2012;Sanchez et al 2011). OC-I was chosen because it is compatible to the 2PP processing and is biocompatible Doraiswamy et al 2005).…”

Section: Two-photon Polymerization (2pp)mentioning

confidence: 99%

Laser polishing and 2PP structuring of inside microfluidic channels in fused silica

Weingarten

Steenhusen

Hermans³

et al. 2017

Microfluid Nanofluid

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This study presents the development of post-processing steps for microfluidics fabricated with selective laser etching (SLE) in fused silica. In a first step, the SLE surface-even inner walls of microfluidic channels—can be smoothed by laser polishing. In addition, two-photon polymerization (2PP) can be used to manufacture polymer microstructures and microcomponents inside the microfluidic channels. The reduction in the surface roughness by laser polishing is a remelting process. While heating the glass surface above softening temperature, laser radiation relocates material thanks to the surface tension. With laser polishing, the RMS roughness of SLE surfaces can be reduced from 12 µm down to 3 nm for spatial wavelength λ < 400 µm. Thanks to the laser polishing, fluidic processes as well as particles in microchannels can be observed with microscopy. A manufactured microfluidic demonstrates that SLE and laser polishing can be combined successfully. By developing two-photon polymerization (2PP) processing in microchannels we aim to enable new applications with sophisticated 3D structures inside the microchannel. With 2PP, lenses with a diameter of 50 µm are processed with a form accuracy rms of 70 nm. In addition, this study demonstrates that 3D structures can be fabricated inside the microchannels manufactured with SLE. Thanks to the combination of SLE, laser polishing and 2PP, research is pioneering new applications for microfluidics made of fused silica

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Applications of advanced hybrid organic–inorganic nanomaterials: from laboratory to market

Cited by 1,289 publications

References 439 publications

Gold–silica quantum rattles for multimodal imaging and therapy

Gold–silica quantum rattles for multimodal imaging and therapy

Harnessing self-assembly strategies for the rational design of conjugated polymer based materials

Laser polishing and 2PP structuring of inside microfluidic channels in fused silica

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