Applications in sleep: How light affects sleep

Santhi, Nayantara; Ball, Danny

doi:10.1016/bs.pbr.2020.05.029

Cited by 10 publications

(10 citation statements)

References 35 publications

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“…Our data show that VL exposure diminished the decrease of choroidal thickness caused by hyperopic defocus, and the effect was also dependent on retinal OPN5. Considering the contribution of other nonvisual photoreceptors in maintaining the homeostasis of organs in individuals ( 57 – 61 ), it is possible that VL/OPN5 pathway plays a role in protecting the eyeball from overreacting to defocus by controlling the thickness of the choroid. The mechanism of OPN5-dependent regulation of choroidal thickness needs further investigation.…”

Section: Discussionmentioning

confidence: 99%

Violet light suppresses lens-induced myopia via neuropsin (OPN5) in mice

Jiang

Pardue

Mori

et al. 2021

Proc. Natl. Acad. Sci. U.S.A.

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Myopia has become a major public health concern, particularly across much of Asia. It has been shown in multiple studies that outdoor activity has a protective effect on myopia. Recent reports have shown that short-wavelength visible violet light is the component of sunlight that appears to play an important role in preventing myopia progression in mice, chicks, and humans. The mechanism underlying this effect has not been understood. Here, we show that violet light prevents lens defocus–induced myopia in mice. This violet light effect was dependent on both time of day and retinal expression of the violet light sensitive atypical opsin, neuropsin (OPN5). These findings identify Opn5-expressing retinal ganglion cells as crucial for emmetropization in mice and suggest a strategy for myopia prevention in humans.

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Section: Discussionmentioning

confidence: 99%

Violet light suppresses lens-induced myopia via neuropsin (OPN5) in mice

Jiang

Pardue

Mori

et al. 2021

Proc. Natl. Acad. Sci. U.S.A.

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“…Sleep onset and maintenance can be influenced by sensory input. For example, ambient light levels can promote or impair sleep onset, in part through circadian rhythm entrainment ( Phipps-Nelson et al, 2003 ; LeGates et al, 2014 ; Santhi and Ball, 2020 ). Similarly, pain can delay sleep onset ( Taylor et al, 2007 ; Eban-Rothschild et al, 2017 ) and auditory stimulation (e.g., music) can reduce stress and pain ( Bernatzky et al, 2011 ; Hauck et al, 2013 ; Feneberg et al, 2021 ), potentially decreasing latency to sleep, while auditory noise can impair sleep ( Smith et al, 2022 ).…”

Section: Odor Modulation Of Sleepmentioning

confidence: 99%

Reciprocal relationships between sleep and smell

Gaeta¹,

Wilson

2022

Front. Neural Circuits

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Despite major anatomical differences with other mammalian sensory systems, olfaction shares with those systems a modulation by sleep/wake states. Sleep modulates odor sensitivity and serves as an important regulator of both perceptual and associative odor memory. In addition, however, olfaction also has an important modulatory impact on sleep. Odors can affect the latency to sleep onset, as well as the quality and duration of sleep. Olfactory modulation of sleep may be mediated by direct synaptic interaction between the olfactory system and sleep control nuclei, and/or indirectly through odor modulation of arousal and respiration. This reciprocal interaction between sleep and olfaction presents novel opportunities for sleep related modulation of memory and perception, as well as development of non-pharmacological olfactory treatments of simple sleep disorders.

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“…For this purpose, we conducted a systematic review to investigate the impact of different illuminance levels in the evening on PSG-assessed sleep of healthy participants in controlled laboratory studies. Based on previously reported light-driven effects on sleep architecture (for reviews, see 18,19 ), we selected the following PSG-derived sleep measures for our analyses: sleep latency, sleep efficiency (i.e., percentage of time asleep during time in bed) and slow wave sleep (i.e., deep sleep, stages 3 and 4 or N3). Firstly, we performed a meta-analysis to test the prediction that pre-sleep light exposure acutely lengthens sleep latency, reduces sleep efficiency and reduces time spent in slow wave sleep.…”

Section: Introductionmentioning

confidence: 99%

Influence of evening light exposure on polysomnographically assessed night-time sleep: A systematic review with meta-analysis

Cajochen

Stefani

Schöllhorn

et al. 2022

Lighting Research & Technology

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Evening exposure to electric light can acutely suppress melatonin levels and adversely affect subsequent sleep. We conducted a systematic review with meta-analysis investigating the influence of evening illuminance levels on polysomnographically (PSG)-assessed sleep. We also explored how melanopsin (expressed in melanopic equivalent daylight illuminance (EDI) affects human sleep features. We included polysomnographic laboratory sleep studies with healthy humans for effects of illuminance and exposure duration, for pre-sleep exposures between 6:00 p.m. to 1:00 a.m. From 440 identified articles, 114 met eligibility criteria for screening, and 21 also reported type of light source/spectral characteristics, with 12 identified as eligible for review. Meta-analysis showed evening light affects sleep latency, sleep efficiency and slow wave sleep, with overall effect sizes (95% confidence interval) of 0.69 (−0.50; 1.88), 0.34 (−0.13; 0.82) and −0.61 (−1.85; 0.62), respectively. Estimated melanopic EDI in the range of 100–1000 lx yielded clear dose–response relationships for sleep latency and sleep efficiency, but not for slow wave sleep. Whilst illuminance and duration indicated no apparent effects for a single evening light exposure on PSG-assessed sleep latency, sleep efficiency and slow wave sleep, we observed evidence for a relationship between light exposure and sleep effects based on melanopic EDI. Hence, melanopic EDI may provide a robust predictor of non-visual responses on human sleep.

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Applications in sleep: How light affects sleep

Cited by 10 publications

References 35 publications

Violet light suppresses lens-induced myopia via neuropsin (OPN5) in mice

Violet light suppresses lens-induced myopia via neuropsin (OPN5) in mice

Reciprocal relationships between sleep and smell

Influence of evening light exposure on polysomnographically assessed night-time sleep: A systematic review with meta-analysis

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