Applications and Limitations of Immunohistochemical Expression of “Napsin-A” in Distinguishing Lung Adenocarcinoma From Adenocarcinomas of Other Organs

Kadivar, Maryam; Boozari, Behnaz

doi:10.1097/pai.0b013e3182612643

Cited by 53 publications

(56 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…47 Thus, we consider that clear cell adenocarcinomas of the ovary and kidney have many common characteristics, including clear cell or papillary morphology, and gene mutation and expression. 48 Lung metastases of renal cancers are difficult to distinguish from primary lung adenocarcinomas by napsin A immunostaining, 49 and our data highlight this difficulty by revealing possible napsin A expression in lung metastases of clear cell adenocarcinoma of the ovary.…”

Section: Discussionmentioning

confidence: 70%

Napsin A is a specific marker for ovarian clear cell adenocarcinoma

et al. 2015

View full text Add to dashboard Cite

Ovarian clear cell adenocarcinoma has a relatively poor prognosis among the ovarian cancer subtypes because of its high chemoresistance. Differential diagnosis of clear cell adenocarcinoma from other ovarian surface epithelial tumors is important for its treatment. Napsin A is a known diagnostic marker for lung adenocarcinoma, and expression of napsin A is reported in a certain portion of thyroid and renal carcinomas. However, napsin A expression in ovarian surface epithelial tumors has not previously been examined. In this study, immunohistochemical analysis revealed that in 71 of 86 ovarian clear cell adenocarcinoma patients (83%) and all of the 13 patients with ovarian clear cell adenofibroma, positive napsin A staining was evident. No expression was observed in 30 serous adenocarcinomas, 11 serous adenomas or borderline tumors, 19 endometrioid adenocarcinomas, 22 mucinous adenomas or borderline tumors, 10 mucinous adenocarcinomas, or 3 yolk sac tumors of the ovary. Furthermore, expression of napsin A was not observed in the normal surface epithelium of the ovary, epithelia of the fallopian tubes, squamous epithelium, endocervical epithelium, or the endometrium of the uterus. Therefore, we propose that napsin A is another sensitive and specific marker for distinguishing ovarian clear cell tumors (especially adenocarcinomas) from other ovarian tumors.

show abstract

Section: Discussionmentioning

confidence: 70%

Napsin A is a specific marker for ovarian clear cell adenocarcinoma

et al. 2015

View full text Add to dashboard Cite

show abstract

“…Adenocarcinomas positive for TTF1 or napsin A in the lung or extrapulmonary sites do not necessarily indicate a lung primary, because TTF1 þ or napsin A þ ADCs have been described in ADCs originating from other organs, particularly endometrial and endocervical ADCs, renal papillary or clear cell, and papillary thyroid carcinomas. [8][9][10] Entrapped benign bronchiolar epithelial cells, alveolar pneumocytes, and alveolar macrophages are positive for napsin A, and these napsin A þ cells in small biopsies or cytologic samples associated with SCC must not be misinterpreted as napsin A þ tumor cells. 8,9 The staining for p63 is relatively less specific for SCC unless the staining is diffusely and strongly positive.…”

Section: Primary Lung Adc and Sccmentioning

confidence: 99%

“…[8][9][10] Entrapped benign bronchiolar epithelial cells, alveolar pneumocytes, and alveolar macrophages are positive for napsin A, and these napsin A þ cells in small biopsies or cytologic samples associated with SCC must not be misinterpreted as napsin A þ tumor cells. 8,9 The staining for p63 is relatively less specific for SCC unless the staining is diffusely and strongly positive. 6,7 A small subset of ADCs and neuroendocrine carcinomas (NECs) can be focally positive for p63.…”

Section: Primary Lung Adc and Sccmentioning

confidence: 99%

“…[1][2][3][4][5][6][7][8][9][10][11][12][13][14][15] Similarly, IHC markers, including p40, cytokeratin (CK) 5/6, CK5, and p63, are used in supporting the diagnosis of SCC. [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16] More than 90% of SCC cases are positive for each of these markers. exclusive (Table 1; Figure 1, a through d).…”

Section: Primary Lung Adc and Sccmentioning

confidence: 99%

See 1 more Smart Citation

Utility of Immunohistochemistry in the Diagnosis of Pleuropulmonary and Mediastinal Cancers: A Review and Update

Zhang

Deng

Cagle

2014

Archives of Pathology &Amp; Laboratory Medicine

View full text Add to dashboard Cite

Context.-Immunohistochemistry has become an indispensable ancillary tool for the accurate classification of pleuropulmonary and mediastinal neoplasms necessary for therapeutic decisions and predicting prognostic outcome in the era of personalized medicine. Diagnostic accuracy has significantly improved because of the continuous discoveries of tumor-associated biomarkers and the development of effective immunohistochemical panels.Objective.-To increase the accuracy of diagnosis and classify pleuropulmonary neoplasms through immunohistochemistry.Data Sources.-Literature review, authors' research data, and personal practice experience.Conclusions.-This review article has shown that appropriately selecting immunohistochemical panels enables pathologists to effectively diagnose most primary pleuropulmonary neoplasms and differentiate primary lung tumors from a variety of metastatic tumors to the lung. The discovery of new mutation-specific antibodies identifying a subset of specific gene-arranged lung tumors provides a promising alternative and cost-effective approach to molecular testing. Knowing the utilities and pitfalls of each tumor-associated biomarker is essential to avoiding potential diagnostic errors.

show abstract

“…In contrast, markers of pulmonary origin (TTF-1 and Napsin-A) were positive. Neither of these markers are 100% specific and/or sensitive, but the overall pattern is in keeping with a pulmonary origin [11,12]. Metastases to the breast are rare, and pulmonary adenocarcinomas are uncommon sources of such seeding [13].…”

Section: Discussionmentioning

confidence: 99%

Solitary breast metastasis from oestrogen receptor-positive pulmonary adenocarcinoma: report of a case with a potential pitfall

Cserni

2017

pjp

View full text Add to dashboard Cite

Solitary breast metastases are rare and mimic primary breast carcinoma. A 60-yearold female with a history of pulmonary adenocarcinoma presented with a solitary left breast lump suspicious for malignancy on breast imaging. Core-needle biopsy disclosed an adenocarcinoma strongly and diffusely positive for oestrogen receptors. Further immunohistochemistry was consistent with the breast tumour being a solitary metastasis of her pulmonary cancer. Clinicians and pathologists should be aware of the fact that pulmonary adenocarcinomas may sometimes display strong rather than only focal positivity for oestrogen receptors by immunohistochemistry and may mimic breast cancer of no special type.

show abstract

Applications and Limitations of Immunohistochemical Expression of “Napsin-A” in Distinguishing Lung Adenocarcinoma From Adenocarcinomas of Other Organs

Cited by 53 publications

References 9 publications

Napsin A is a specific marker for ovarian clear cell adenocarcinoma

Napsin A is a specific marker for ovarian clear cell adenocarcinoma

Utility of Immunohistochemistry in the Diagnosis of Pleuropulmonary and Mediastinal Cancers: A Review and Update

Solitary breast metastasis from oestrogen receptor-positive pulmonary adenocarcinoma: report of a case with a potential pitfall

Contact Info

Product

Resources

About