Solitary breast metastasis from oestrogen receptor-positive pulmonary adenocarcinoma: report of a case with a potential pitfall

Abstract

Solitary breast metastases are rare and mimic primary breast carcinoma. A 60-yearold female with a history of pulmonary adenocarcinoma presented with a solitary left breast lump suspicious for malignancy on breast imaging. Core-needle biopsy disclosed an adenocarcinoma strongly and diffusely positive for oestrogen receptors. Further immunohistochemistry was consistent with the breast tumour being a solitary metastasis of her pulmonary cancer. Clinicians and pathologists should be aware of the fact that pulmonary adenocarcinomas may sometimes display strong rather than only focal positivity for oestrogen receptors by immunohistochemistry and may mimic breast cancer of no special type.

Breast metastasis from EGFR‐mutated lung adenocarcinoma: A case report and review of the literature

“…Indeed, only 43 cases were identified in literature from 1989 to 2013 . Eighteen additional cases with detailed clinical information from 2013 to 2017 were identified in our literature search of the PubMed database (Table ) . Of these 18 cases, four involved male patients and 14 female patients, with ages ranging from 40 to 74 years (average, 56.5 years).…”