Application Progress of Nano Silver Dressing in the Treatment of Diabetic Foot

Lin, Huijing; Bolatai, Alayi; Wu, Na

doi:10.2147/dmso.s330322

Cited by 10 publications

(5 citation statements)

References 26 publications

(40 reference statements)

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“…Silver dressing has been shown in several trials to be helpful in treating DFUs. Researchers have shown that silver ion dressings may destroy germs, enhance the wound-healing environment, hydrate and soften necrotic tissue, and clean the wound, all while releasing silver ions [ 72 ]. Bacteria that are negatively charged are drawn to silver ions because of their negative charge, which enhances the permeability of the outer membrane and causes apoptosis.…”

Section: Therapeutic Methods Used To Manage Dfu Infectionsmentioning

confidence: 99%

An Overview of Diabetic Foot Ulcers and Associated Problems with Special Emphasis on Treatments with Antimicrobials

Baig¹,

Banu

Zehravi

et al. 2022

Life

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One of the most significant challenges of diabetes health care is diabetic foot ulcers (DFU). DFUs are more challenging to cure, and this is particularly true for people who already have a compromised immune system. Pathogenic bacteria and fungi are becoming more resistant to antibiotics, so they may be unable to fight microbial infections at the wound site with the antibiotics we have now. This article discusses the dressings, topical antibacterial treatment, medications and debridement techniques used for DFU and provides a deep discussion of DFU and its associated problems. English-language publications on DFU were gathered from many different databases, such as Scopus, Web of Science, Science Direct, Springer Nature, and Google Scholar. For the treatment of DFU, a multidisciplinary approach involving the use of diagnostic equipment, skills, and experience is required. Preventing amputations starts with patient education and the implementation of new categorization systems. The microbiota involved in DFU can be better understood using novel diagnostic techniques, such as the 16S-ribosomal DNA sequence in bacteria. This could be achieved by using new biological and molecular treatments that have been shown to help prevent infections, to control local inflammation, and to improve the healing process.

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Section: Therapeutic Methods Used To Manage Dfu Infectionsmentioning

confidence: 99%

An Overview of Diabetic Foot Ulcers and Associated Problems with Special Emphasis on Treatments with Antimicrobials

Baig¹,

Banu

Zehravi

et al. 2022

Life

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“…Nano silver, nano copper, nano copper oxide, nano zinc oxide and nano gold have been widely used in research ( 124 ). With the advancement of nanotechnology, it is possible to produce nanoscale sterling silver particles.…”

Section: Classification and Active Ingredients Of Dressingsmentioning

confidence: 99%

Current status and progress in research on dressing management for diabetic foot ulcer

Jiang,

Li,

Luo

et al. 2023

Front. Endocrinol.

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Diabetic foot ulcer (DFU) is a major complication of diabetes and is associated with a high risk of lower limb amputation and mortality. During their lifetime, 19%–34% of patients with diabetes can develop DFU. It is estimated that 61% of DFU become infected and 15% of those with DFU require amputation. Furthermore, developing a DFU increases the risk of mortality by 50%–68% at 5 years, higher than some cancers. Current standard management of DFU includes surgical debridement, the use of topical dressings and wound decompression, vascular assessment, and glycemic control. Among these methods, local treatment with dressings builds a protective physical barrier, maintains a moist environment, and drains the exudate from DFU wounds. This review summarizes the development, pathophysiology, and healing mechanisms of DFU. The latest research progress and the main application of dressings in laboratory and clinical stage are also summarized. The dressings discussed in this review include traditional dressings (gauze, oil yarn, traditional Chinese medicine, and others), basic dressings (hydrogel, hydrocolloid, sponge, foam, film agents, and others), bacteriostatic dressings, composite dressings (collagen, nanomaterials, chitosan dressings, and others), bioactive dressings (scaffold dressings with stem cells, decellularized wound matrix, autologous platelet enrichment plasma, and others), and dressings that use modern technology (3D bioprinting, photothermal effects, bioelectric dressings, microneedle dressings, smart bandages, orthopedic prosthetics and regenerative medicine). The dressing management challenges and limitations are also summarized. The purpose of this review is to help readers understand the pathogenesis and healing mechanism of DFU, help physicians select dressings correctly, provide an updated overview of the potential of biomaterials and devices and their application in DFU management, and provide ideas for further exploration and development of dressings. Proper use of dressings can promote DFU healing, reduce the cost of treating DFU, and reduce patient pain.

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“…The application of this dressing on the skin prevents bacterial invasion of the wound and protects the tissue from the damage to the wound surface. In addition, silver-containing dressings can improve short-term wounds and ulcers [ 57 ]. Xu et al [ 58 ], observed the clinical efficacy of silver ion dressing combined with polyhexamethylenebiguanide (PHBM) dressing, and the results showed that the total efficiency of silver ions combined with PHBM for the therapy of DFU infected wounds was significantly higher than that of the PHBM alone control group, which not only had a strong antibacterial effect, but also reduced the inflammatory reaction of the ulcer surface, promoted the growth of granulation tissue, shortened the therapy time, and improved the prognosis.…”

Section: Diabetic Wounds and Diabetic Dressingsmentioning

confidence: 99%

Advances in the Preparation of Nanofiber Dressings by Electrospinning for Promoting Diabetic Wound Healing

Liu

Feng

et al. 2022

Biomolecules

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Chronic diabetic wounds are one of the main complications of diabetes, manifested by persistent inflammation, decreased epithelialization motility, and impaired wound healing. This will not only lead to the repeated hospitalization of patients, but also bear expensive hospitalization costs. In severe cases, it can lead to amputation, sepsis or death. Electrospun nanofibers membranes have the characteristics of high porosity, high specific surface area, and easy functionalization of structure, so they can be used as a safe and effective platform in the treatment of diabetic wounds and have great application potential. This article briefly reviewed the pathogenesis of chronic diabetic wounds and the types of dressings commonly used, and then reviewed the development of electrospinning technology in recent years and the advantages of electrospun nanofibers in the treatment of diabetic wounds. Finally, the reports of different types of nanofiber dressings on diabetic wounds are summarized, and the method of using multi-drug combination therapy in diabetic wounds is emphasized, which provides new ideas for the effective treatment of diabetic wounds.

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Application Progress of Nano Silver Dressing in the Treatment of Diabetic Foot

Cited by 10 publications

References 26 publications

An Overview of Diabetic Foot Ulcers and Associated Problems with Special Emphasis on Treatments with Antimicrobials

An Overview of Diabetic Foot Ulcers and Associated Problems with Special Emphasis on Treatments with Antimicrobials

Current status and progress in research on dressing management for diabetic foot ulcer

Advances in the Preparation of Nanofiber Dressings by Electrospinning for Promoting Diabetic Wound Healing

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