Application of x-ray phase contrast imaging to microscopic identification of Chinese medicines

Wei, Xun; Xiao, Tiqiao; Liu, Lixiang; Du, Guohao; Chen, Min; Luo, Yu; Xu, Hongjie

doi:10.1088/0031-9155/50/18/003

Cited by 8 publications

(6 citation statements)

References 21 publications

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“…The edge‐enhanced images produced by the PPCI approach are very useful, allowing for visualization of boundaries with different refraction properties. Wei et al successfully utilized PPCI to investigate the microstructures of traditional Chinese medicines . Moreover, the phase information contained in PPCI radiographic fringes could be extracted by means of phase‐retrieval, which enables the phase shift imposed on the wave by the sample to be recovered from the diffracted intensity distribution in the image plane or planes .…”

Section: Methodology Developmentmentioning

confidence: 99%

X‐ray Imaging for Non‐Destructive Microstructure Analysis at SSRF

et al. 2014

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The X-ray imaging beamline at the Shanghai Synchrotron Radiation Facility is aimed at developing and evaluating the effectiveness of synchrotron radiation (SR)-based imaging techniques in planar or computed tomography modalities. Several X-ray imaging methods are in use and find extensive applications in many research fields. In this Essay, the status of the methodology development at the beamline is discussed and applications are reviewed.

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Section: Methodology Developmentmentioning

confidence: 99%

X‐ray Imaging for Non‐Destructive Microstructure Analysis at SSRF

et al. 2014

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“…To date, XPCMT has been used successfully for plant research [26], [27], [28]. X-ray phase-contrast microscopy has already provided preliminary exploratory results [29], [30], and XPCMT has been adapted to study CMM raw materials [3], [4]. In this study, XPCMT data processing using the phase-retrieval method was employed to obtain quantitative information about the microstructure of ginseng.…”

Section: Methodsmentioning

confidence: 99%

Identification of ginseng root using quantitative X-ray microtomography

Xue

Wang

et al. 2017

Journal of Ginseng Research

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BackgroundThe use of X-ray phase-contrast microtomography for the investigation of Chinese medicinal materials is advantageous for its nondestructive, in situ, and three-dimensional quantitative imaging properties.MethodsThe X-ray phase-contrast microtomography quantitative imaging method was used to investigate the microstructure of ginseng, and the phase-retrieval method is also employed to process the experimental data. Four different ginseng samples were collected and investigated; these were classified according to their species, production area, and sample growth pattern.ResultsThe quantitative internal characteristic microstructures of ginseng were extracted successfully. The size and position distributions of the calcium oxalate cluster crystals (COCCs), important secondary metabolites that accumulate in ginseng, are revealed by the three-dimensional quantitative imaging method. The volume and amount of the COCCs in different species of the ginseng are obtained by a quantitative analysis of the three-dimensional microstructures, which shows obvious difference among the four species of ginseng.ConclusionThis study is the first to provide evidence of the distribution characteristics of COCCs to identify four types of ginseng, with regard to species authentication and age identification, by X-ray phase-contrast microtomography quantitative imaging. This method is also expected to reveal important relationships between COCCs and the occurrence of the effective medicinal components of ginseng.

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“…Since Röntgen discovered X-rays in 1895, X-ray imaging techniques have been applied in clinical diagnosis, industrial nondestructive inspections and many other areas. However, until 2005 [12], this technique was not employed in the field of the identification of CMMs. When an X-ray wave traverses an object, its amplitude and phase change, resulting in attenuation, interference, and refraction, and in X-ray phase-contrast imaging these are converted into intensity changes.…”

Section: Two-dimensional Characteristic Microstructures Of Cmmsmentioning

confidence: 99%

“…By using this laboratory X-ray imaging system described above, Wei et al began the microscopic identification of CMMs in 2004, even before the ground-breaking of the Shanghai Synchrotron Radiation Facility(SSRF) [12,40]. Some of the first research results are shown in figure 4.…”

Section: Two-dimensional Microstructures Imaged By X-ray Tube Based Xpcimentioning

confidence: 99%

Microscopic identification of Chinese medicinal materials based on X-ray phase contrast imaging: from qualitative to quantitative

et al. 2016

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JINST 11 C07001phase contrast micro-CT for investigating the characteristic microstructures of CMMs. During this period, a variety of typical CMMs have been investigated, from two-dimensional (2D) radiography to three-dimensional (3D) micro-CT, from qualitative to quantitative. Taken together, these results verify that quantitative X-ray phase contrast micro-CT is a practical tool for the microscopic investigation of CMMs. Additionally, further efforts are being made to find the relationship between the microstructures' quantitative factors and active chemical components. At present, experimental results have demonstrated that the quality of CMMs can be evaluated directly via the quantitative information of their characteristic microstructures. K: Computerized Tomography (CT) and Computed Radiography (CR); X-ray radiography and digital radiography (DR)

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Application of x-ray phase contrast imaging to microscopic identification of Chinese medicines

Cited by 8 publications

References 21 publications

X‐ray Imaging for Non‐Destructive Microstructure Analysis at SSRF

X‐ray Imaging for Non‐Destructive Microstructure Analysis at SSRF

Identification of ginseng root using quantitative X-ray microtomography

Microscopic identification of Chinese medicinal materials based on X-ray phase contrast imaging: from qualitative to quantitative

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