analyses can improve understanding of the impact of global change on pesticide pollution. This type of study is lacking in China.Food production is a large contributor to both nutrient and pesticide pollution in Chinese waters. However, other water pollutants exist. Moreover, under global change, losses of all pollutants associated with food production may change (Savary et al. 2014).These pollutants are interrelated, because they may have common sources or affect the same sectors. Moreover, they may interact in the environment. However, current modelling studies often analyze water quality for nutrients and pesticides separately for China, especially for large-scale water quality assessment. For air pollution problems, models are available that adopt a multi-pollutant perspective (Amann et al. 2004;Wagner et al. 2013). Such integrated models have successfully supported the international negotiation on air pollution control. For water pollution such integrated approaches are scarce. Therefore, a large-scale water quality model taking multipollutant perspectives will be the next focus of water quality assessments. P a g e | 10 Figure 1.1 The structure of the PhD thesis. Chapters are presented with their research objectives. Main methods that have been used are given for Chapters 2-5. SSPs-RCPs refers to the combination of Shared Socioeconomic Pathways (O'Neill et al. 2014) and Representative Concentration Pathways (Van Vuuren et al. 2011). MARINA is short for the Model to Assess River Inputs of Nutrients to seAs (Strokal et al. 2016a).