Application of Vitamin E TPGS in ocular therapeutics – Attributes beyond excipient

Sharma, Pankaj Kumar; Sharma, Hunny; Chakole, Chandrashekhar Mahadeo; Pandey, Jaya; Chauhan, Meenakshi Kanwar

doi:10.1016/j.jics.2022.100387

Cited by 9 publications

(7 citation statements)

References 97 publications

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“…Age-related disorders are most frequently brought on by oxidative stress, despite the fact that the exact aetiology is uncertain. As a result, TPGS may be a great alternative to conventional drugs in treating these conditions, acting as a neuroprotectant in age-related diseases [57].…”

Section: Vitamin E Tpgsmentioning

confidence: 99%

“…In recent years, TPGS has been studied for ocular disorders along with several drugs such as cyclosporine (a micellar system was produced using Poloxamer and vitamin E TPGS to enhance drug concentration during delivery);curcumin (formulated with Pluronic P123 (P123) and vitamin E TPGS to increase permeation across cornea); rapamycin (formulated using vitamin E TPGS and octoxynol-40 to enhance its water solubility); acyclovir (formulated with vitamin E TPGS and octoxynol-4 to slow the release of drug and site specific absorption); riboflavin (to improve riboflavin penetration across the cornea even without removing the epithelium); dexamethasone (formulated with polylactide-co-glycolide (PLGA) and vitamin E TPGS to decrease the limitations of the posterior segment drug delivery); dorzolamide (to overcome the problem of frequent instillation) and timolol (to enhance intraocular pressure reduction capability of contact lens even at lower dose) [57].…”

Section: Vitamin E Tpgsmentioning

confidence: 99%

See 1 more Smart Citation

Novel Topical Drug Delivery Systems in Ophthalmic Applications

Rajput¹,

Sharma²,

Sharma³

et al. 2023

Dosage Forms - Innovation and Future Perspectives

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The eye is the utmost attention-grabbing organ owed to its drug disposition characteristics. Generally, topical application (90% are eye drops) is the method of choice because of its patient compliance and safety. Transcorneal penetration is the major route for ophthalmic drug absorption. However, corneal absorption has been observed to be slower process as compared to elimination. Therefore, conventional dosage forms are associated with rapid precorneal drug loss. Thus, to improve ocular drug bioavailability, there is a substantial effort directed toward the development of novel topical drug delivery systems for ophthalmic administration. These novel delivery systems (Contact lenses, In situ gels, Microemulsions, Niosomes, Liposomes, Implants, Microspheres, and Micelles) provide the controlled release behaviour for treating the chronic ailments, and help patients and doctors to curtail the dosing frequency and invasive method of treatment. Hence, the current chapter discusses the progress of novel topical ocular drug delivery systems in the pharmaceutical industry.

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Section: Vitamin E Tpgsmentioning

confidence: 99%

Section: Vitamin E Tpgsmentioning

confidence: 99%

Novel Topical Drug Delivery Systems in Ophthalmic Applications

Rajput¹,

Sharma²,

Sharma³

et al. 2023

Dosage Forms - Innovation and Future Perspectives

View full text Add to dashboard Cite

show abstract

“…TPGS also has antioxidant activity [45] not seen with PEG, which can protect against the oxidative degradation of drugs in formulations during storage, thus enhancing the stability of formulations [46]. Similarly, as an antioxidant agent, TPGS has been used to develop many ocular formulations to prevent oxidative stress accompanying ophthalmic diseases such as glaucoma and cataracts [47].…”

Section: Properties Of Tpgs Relevant To Drug Deliverymentioning

confidence: 99%

TPGS Decorated Liposomes as Multifunctional Nano-Delivery Systems

Farooq

Trevaskis

2022

Pharm Res

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Liposomes are sphere-shaped vesicles that can capture therapeutics either in the outer phospholipid bilayer or inner aqueous core. Liposomes, especially when surface-modified with functional materials, have been used to achieve many benefits in drug delivery, including improving drug solubility, oral bioavailability, pharmacokinetics, and delivery to disease target sites such as cancers. Among the functional materials used to modify the surface of liposomes, the FDA-approved non-ionic surfactant D-alpha-tocopheryl polyethylene glycol succinate (TPGS) is increasingly being applied due to its biocompatibility, lack of toxicity, applicability to various administration routes and ability to enhance solubilization, stability, penetration and overall pharmacokinetics. TPGS decorated liposomes are emerging as a promising drug delivery system for various diseases and are expected to enter the market in the coming years. In this review article, we focus on the multifunctional properties of TPGS-coated liposomes and their beneficial therapeutic applications, including for oral drug delivery, vaccine delivery, ocular administration, and the treatment of various cancers. We also suggest future directions to optimise the manufacture and performance of TPGS liposomes and, thus, the delivery and effect of encapsulated diagnostics and therapeutics.

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“…Nanotechnology is the science that forms the basis of utilization of nanomedicines in prevention and curing different diseases by means of suitable nanoparticles and nanobots which are utilized in a wide range of applications including diagnosis, drug delivery, and activating targets in a living system [11][12][13]. The past decade studi es interpreted that the biological response and nano interaction significantly plays an important role in designing the nanoparticles for effective drug delivery.…”

Section: Basics Of Nanotechnology Based Techniques In Designing Nanom...mentioning

confidence: 99%

Nanomedicines: A Focus on Nanomaterials as Drug Delivery System with Current Trends and Future Advancement

et al. 2022

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The rapid advancement of nanomedicine presents novel alternatives that have the potential to transform health care. Targeted drug delivery as well as the synthesis of nanocarriers is a growing discipline that has been intensively researched to reduce the complexity of present medicines in a variety of diseases and to develop new treatment and diagnostic techniques. There are several designed nanomaterials used as a delivery system such as liposomes, micelles, dendrimers, polymers, carbon-based materials, and many other substances, which deliver the drug moiety directly into its targeted body area reducing toxic effect of conventional drug delivery, thus reducing the amount of drug required for therapeutic efficacy and offering many more advantages. Currently, these are used in many applications, including cancer treatment, imaging contrast agents, and biomarker detection and so on. This review provides a comprehensive update in the field of targeted nano-based drug delivery systems, by conducting a thorough examination of the drug synthesis, types, targets, and application of nanomedicines in improving the therapeutic efficiency.

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Application of Vitamin E TPGS in ocular therapeutics – Attributes beyond excipient

Cited by 9 publications

References 97 publications

Novel Topical Drug Delivery Systems in Ophthalmic Applications

Novel Topical Drug Delivery Systems in Ophthalmic Applications

TPGS Decorated Liposomes as Multifunctional Nano-Delivery Systems

Nanomedicines: A Focus on Nanomaterials as Drug Delivery System with Current Trends and Future Advancement

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