Application of the solvent extraction technique to investigation of the anti-inflammatory activity of adlay bran

Huang, Din Wen; Wu, Chi Hao; Shih, Chun Kuang; Liu, Chia-Yu; Shih, Pei‐Yu; Shieh, Tzong‐Ming; Lin, Chin-Kai; Chiang, Wenchang; Hsia, Shih Min

doi:10.1016/j.foodchem.2013.08.071

Cited by 36 publications

(20 citation statements)

References 16 publications

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“…The 80% ethanol eluate was collected and concentrated under vacuum at 45 °C, and then lyophilized at −20 °C for 48 h (Huang et al. 2014).…”

Section: Methodsmentioning

confidence: 99%

Coix lachryma-jobi extract ameliorates inflammation and oxidative stress in a complete Freund’s adjuvant-induced rheumatoid arthritis model

Zhang

Shi³

et al. 2019

Pharmaceutical Biology

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Context: Adlay seed [Job’s tears, Coix lachryma-jobi L. var. ma-yuen Stapf (Poaceae)] is a Traditional Chinese Medicine, which has been investigated to treat inflammatory diseases and rheumatism.Objective: This study evaluates the ameliorative effects of adlay seed extract (ASE) in a complete Freund’s adjuvant (CFA)-induced rheumatoid arthritis (RA) rats.Materials and methods: The RA Sprague–Dawley rat model was induced and randomly divided into six groups with or without ASE treatment (50, 100 or 200 mg/kg). After 28 d administration, the symptoms, biochemical parameters and molecular mechanisms were investigated.Results: The values of paw oedema, PGE2 and MMP-3 decreased from 1.46 ± 0.04 to 0.66 ± 0.07 cm3, from 126.2 ± 11.48 to 79.71 ± 6.8 pg/mL and from 142.7 ± 8.36 to 86.51 ± 5.95 ng/mL, respectively; the values of body weight increased from 177.25 ± 5.94 to 205 ± 6.52 g in HASE group. In addition, treatment of ASE reduced the levels of pro-inflammatory cytokines (IL-1β, TNF-α, IL-6, MCP-1), and increased the activities of antioxidant enzyme (GSH-Px, SOD, and CAT). Furthermore, ASE could suppress the mRNA expression of COX-2 and CHI3L1 and improve the mRNA expression of CAT and GPx-1 in ankle tissues of RA rats.Discussion and conclusions: For the first time, our results indicated ASE exerts anti-RA effects via inhibiting pro-inflammatory factors and alleviating oxidative stress. Our finding sheds light on the research and development of anti-RA functional foods from adlay seed.

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“…The 80% ethanol eluate was collected and concentrated under vacuum at 45 °C, and then lyophilized at −20 °C for 48 h (Huang et al. 2014).…”

Section: Methodsmentioning

confidence: 99%

Coix lachryma-jobi extract ameliorates inflammation and oxidative stress in a complete Freund’s adjuvant-induced rheumatoid arthritis model

Zhang

Shi³

et al. 2019

Pharmaceutical Biology

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“…Mechanistically, NF-κB has been shown to be a well-known target of anti-inflammatory actions of adlay ( 31 , 53 ). However, the intestinal regulation of inflammatory signals by adlay was not mediated by the canonical pro-inflammatory NF-κB-linked pathway.…”

Section: Discussionmentioning

confidence: 99%

“…In particular, contamination with trichothecene mycotoxins including DON in adlay grains frequently occurs because of improperly practiced postharvest procedures ( 5 ). Adlay grains and their components have been shown to possess anticancer ( 25 ), antioxidant ( 26 , 27 ), antiallergic ( 28 ), and anti-inflammatory activities ( 29 – 31 ). On the basis of assumption that gastrointestinal actions of DON could be affected by adlay consumption, we simulated the impacts of co-exposure to DON and adlay using an enterocyte culture model and investigated the detailed molecular mechanisms of nutritional crosstalk in the gastrointestinal barrier, the early frontline of defense against xenobiotics and pathogens.…”

Section: Introductionmentioning

confidence: 99%

Fungal Deoxynivalenol-Induced Enterocyte Distress Is Attenuated by Adulterated Adlay: In Vitro Evidences for Mucoactive Counteraction

Kim

et al. 2018

Front. Immunol.

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Adlay is a cereal crop that has long been used as traditional herbal medicine and as a highly nourishing food. However, deoxynivalenol (DON), the most prevalent trichothecene mycotoxin worldwide, frequently spoils grains, including adlay, via fungal infection. On the basis of an assumption that the actions of DON in the gut could be modified by adlay consumption, we simulated the impacts of co-exposure in enterocytes and investigated the effectiveness of treatment with adlay for reducing the risk of DON-induced inflammation and epithelia barrier injury. In particular, adlay suppressed DON-induced pro-inflammatory signals such as mitogen-activated kinase transduction and the epidermal growth factor receptor-linked pathway. In addition to regulation of pro-inflammatory responses, adlay treatment interfered with DON-induced disruption of the epithelial barrier. Mechanistically, adlay could boost the activation of protein kinase C (PKC) and cytosolic translocation of human antigen R (HuR) protein, which played critical roles in the epithelial restitution, resulting in protection against disruption of enterocyte barrier integrity. Notably, DON abrogated the Ras homolog gene family member A GTPase-mediated actin cytoskeletal network, which was diminished by adlay treatment in PKC and HuR-dependent ways. Taken together, this study provides evidences for adlay-based attenuation of trichothecene-induced gut distress, implicating potential use of a new gut protector against enteropathogenic insults in diets.

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“…In addition, significant amounts of phytosterols, phenolic compounds, and flavonoids are present in the adlay bran [ 11 ]. Although the exact active components in adlay bran are currently unknown, phenolic compounds and flavonoids had been shown to contribute to the antioxidant and anti-inflammatory actions of adlay bran [ 8 , 9 , 12 ]. In terms of molecular mechanisms of action, adlay bran had been demonstrated to exert anti-inflammatory effects through suppression of COX-2 expression [ 7 ] and inhibition of nitric oxide production [ 8 ].…”

Section: Discussionmentioning

confidence: 99%

“…Although the exact active components in adlay bran are currently unknown, phenolic compounds and flavonoids had been shown to contribute to the antioxidant and anti-inflammatory actions of adlay bran [ 8 , 9 , 12 ]. In terms of molecular mechanisms of action, adlay bran had been demonstrated to exert anti-inflammatory effects through suppression of COX-2 expression [ 7 ] and inhibition of nitric oxide production [ 8 ]. In addition, adlay bran had been shown to mediate antioxidant activity through scavenging of superoxide anion radicals [ 12 ].…”

Section: Discussionmentioning

confidence: 99%

Prophylactic Treatment with Adlay Bran Extract Reduces the Risk of Severe Acute Radiation Dermatitis: A Prospective, Randomized, Double-Blind Study

Huang

Hou

Kan

et al. 2015

Evidence-Based Complementary and Alternative Medicine

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Acute radiation dermatitis is a frequent adverse effect in patients with breast cancer undergoing radiotherapy, but there are only a small number of studies providing evidence-based interventions for this clinical condition. Adlay is a cereal crop that has been previously shown to have anti-inflammatory and antioxidant properties. In this study, we seek to evaluate the effectiveness of oral prophylactic treatment with adlay bran extract in reducing the risk of severe acute radiation dermatitis. A total of 110 patients with breast cancer undergoing radiotherapy were analyzed. Using a prospective, randomized, double-blind design, 73 patients received oral treatment with adlay bran extract and 37 patients received olive oil (placebo). Treatment was started at the beginning of radiation therapy and continued until the termination of radiation treatment. Our results showed that the occurrence of severe acute radiation dermatitis (RTOG grade 2 or higher) was significantly lower in patients treated with oral adlay bran extract compared to placebo (45.2% versus 75.7%, adjusted odds ratio 0.24). No serious adverse effects from adlay bran treatment were noted. In conclusion, prophylactic oral treatment with adlay bran extract reduces the risk of severe acute radiation dermatitis and may have potential use in patients with breast cancer undergoing radiotherapy.

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Application of the solvent extraction technique to investigation of the anti-inflammatory activity of adlay bran

Cited by 36 publications

References 16 publications

Coix lachryma-jobi extract ameliorates inflammation and oxidative stress in a complete Freund’s adjuvant-induced rheumatoid arthritis model

Coix lachryma-jobi extract ameliorates inflammation and oxidative stress in a complete Freund’s adjuvant-induced rheumatoid arthritis model

Fungal Deoxynivalenol-Induced Enterocyte Distress Is Attenuated by Adulterated Adlay: In Vitro Evidences for Mucoactive Counteraction

Prophylactic Treatment with Adlay Bran Extract Reduces the Risk of Severe Acute Radiation Dermatitis: A Prospective, Randomized, Double-Blind Study

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