Application of the Principles of Green Chemistry for the Development of a New and Sensitive Method for Analysis of Ertapenem Sodium by Capillary Electrophoresis

Pedroso, Tahisa Marcela; Schepdael, Ann Van; Salgado, Hérida Regina Nunes

doi:10.1155/2019/1456313

Cited by 9 publications

(3 citation statements)

References 35 publications

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“…With the trend of "back to nature", more efficient, economical, and environmentally friendly methods are required [7]. Among modern analytical separation techniques, CE, featuring convenient operation, high efficiency, quick analysis, and low solvent consumption in determining analytes, is a good alternative choice to meet the requirements of modern green chemistry [8]. Hence, it becomes an effective tool in the analysis of trace amounts of analytes in complex matrices such as biological sam-ples and traditional Chinese medicines [9][10][11].…”

Section: Introductionmentioning

confidence: 99%

Miniaturized matrix solid‐phase dispersion and solid‐phase clear‐up combined with capillary electrophoresis for efficient determination of trace bioactive components in complicated sample matrix: Take Wubi Shanyao Pill as an example

Wei

Yaxin

Zang

et al. 2023

J of Separation Science

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Accurate quantitative analysis of trace analytes in a complicated matrix is a challenge in modern analytical chemistry. An appropriate analytical method is considered to be one of the most common gaps during the whole process. In this study, a green and efficient strategy based on miniaturized matrix solid-phase dispersion and solid-phase extraction combined with capillary electrophoresis was first proposed for extracting, purifying and determining target analytes from complicated matrix, using Wubi Shanyao Pill as an example. In detail, 60 mg of samples were dispersed on MCM-48 to obtain high yields of analytes, then the extract was purified with a solid-phase extraction cartridge. Finally, four analytes in the purified sample solution were determined by capillary electrophoresis. The parameters affecting the extraction efficiency of matrix solid-phase dispersion, purification efficiency of solid-phase extraction and separation effect of capillary electrophoresis were investigated. Under the optimized conditions, all analytes demonstrated satisfactory linearity (R 2 >0.9983). What's more, the superior green potential of the developed method for the determination of complex samples was confirmed by the Analytical GREEnness Metric Approach. The established method was successfully applied in the accurate determination of target analytes in Wubi Shanyao Pill and thus provided reliable, sensitive, and efficient strategy support for its quality control.

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Section: Introductionmentioning

confidence: 99%

Miniaturized matrix solid‐phase dispersion and solid‐phase clear‐up combined with capillary electrophoresis for efficient determination of trace bioactive components in complicated sample matrix: Take Wubi Shanyao Pill as an example

Wei

Yaxin

Zang

et al. 2023

J of Separation Science

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show abstract

“…In addition, they do not present any danger for the operator. Although CE is intrinsically a green analytical method, this appellation is scarcely used and reported in literature [20][21][22][23].…”

Section: Introductionmentioning

confidence: 99%

Evaluation of greenness and analytical performances of separative methods for chiral separation of novel lactam‐based P2RX7‐antagonists

Avigo,

Furman,

Ghinet

et al. 2023

Electrophoresis

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In this work, a preparative supercritical fluid chromatography (SFC) method was first developed to separate a series of chiral compounds evaluated as lactam‐based P2RX7 antagonists. Subsequently, high‐performance liquid chromatography, SFC, and capillary electrophoresis (CE) were comparatively investigated as QC tools to determine the enantiomeric purity of the separated isomers, including analytical performance and greenness. The screening of the best conditions was carried out in liquid and SFC on the nine derivatives and the amylose tris(3,5‐dimethylphenylcarbamate)‐based chiral stationary phase was found to be highly efficient. The same screening was carried out in CE and very different conditions, either in acidic or basic background electrolyte and different cyclodextrins used as chiral selectors, allowed the separation of six of the nine derivatives. 1‐((3,4‐Dichlorophenyl)carbamoyl)‐5‐oxopyrrolidine‐2‐carboxylic acid (compound 1) was chosen as a probe, and its semi‐preparative separation by SFC and enantiomeric verification using the three techniques are presented. Its limit of detection and limit of quantification are calculated for each method. Finally, the greenness of each quality control method was evaluated.

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“…Furthermore, a greener approach to potentially routine analytical methods makes them cheaper, and thus more sustainable in the long term. Capillary electrophoresis has been shown to be a great tool for achieving these goals [ 11 , 12 , 13 , 14 ].…”

Section: Introductionmentioning

confidence: 99%

Rapid Capillary Electrophoresis Method for Simultaneous Determination of Abemaciclib, Ribociclib, and Palbociclib in Pharmaceutical Dosage Forms: A Green Approach

et al. 2022

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Advances in the treatment of HR+/HER2- breast cancer phenotype have been made with the introduction of abemaciclib, ribociclib, and palbociclib, inhibitors of cyclin D dependent kinases 4 and 6 (CDK4/6). Here, a novel, fast, cheap, and green CE method for the simultaneous determination of these three CDK4/6 in less than 4 min is proposed for the first time. Separation was achieved by capillary zone electrophoresis in an acidic medium, in accordance with the structures of the analytes and their pKa values. The optimal pH of the running buffer was found to be 2.9. The optimal method conditions were 27.5 kV separation voltage, 30 °C, 5 s injection time under 50 mbar pressure, and 50 mM phosphate background buffer with benzimidazole as an internal standard. The developed method was validated with respect to robustness, selectivity, accuracy, precision, linearity, and limits of detection. The method was shown to be linear in the range of 10 to 100 µg mL−1 with correlation coefficients higher than 0.9981. A greenness assessment of the proposed method was performed, and the method was shown to be green. The validated method was successfully applied to pharmaceutical dosage forms of all CDK4/6 inhibitors.

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Application of the Principles of Green Chemistry for the Development of a New and Sensitive Method for Analysis of Ertapenem Sodium by Capillary Electrophoresis

Cited by 9 publications

References 35 publications

Miniaturized matrix solid‐phase dispersion and solid‐phase clear‐up combined with capillary electrophoresis for efficient determination of trace bioactive components in complicated sample matrix: Take Wubi Shanyao Pill as an example

Miniaturized matrix solid‐phase dispersion and solid‐phase clear‐up combined with capillary electrophoresis for efficient determination of trace bioactive components in complicated sample matrix: Take Wubi Shanyao Pill as an example

Evaluation of greenness and analytical performances of separative methods for chiral separation of novel lactam‐based P2RX7‐antagonists

Rapid Capillary Electrophoresis Method for Simultaneous Determination of Abemaciclib, Ribociclib, and Palbociclib in Pharmaceutical Dosage Forms: A Green Approach

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