Application of the Freundlich adsorption isotherm in the characterization of molecularly imprinted polymers

Umpleby, Robert J.; Baxter, Suzanne Domel; Bode, Miguel; Berch, John K.; Shah, Ripal N.; Shimizu, Ken D.

doi:10.1016/s0003-2670(00)01211-3

Cited by 257 publications

(178 citation statements)

References 43 publications

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“…Experimental sorption parameters (m, a, R 2 ) of Freundlich model for MIP and NIP are presented in Table 1. The heterogeneity index m obtained for the NIP is higher than that of the MIP, which is in agreement with previous study [22] that revealed the comparison of imprinted polymers with non imprinted polymer.…”

Section: Adsorption Isothermsupporting

confidence: 92%

“…The obtained data of adsorption isotherm equilibrium was analyzed using the Langmuir, Schatcard and Freundlich isotherm models [20][21][22]. The experimental data for various studied were fitted better with the rearranged Freundlich isotherm model over the Langmuir or Schatcard as the experimental data fall on a straight line when plotted in a logB vs logF format.…”

Section: Adsorption Isothermmentioning

confidence: 99%

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A Molecularly Imprinted Polymer for the Selective Solid-Phase Extraction of Ibuprofen from Urine Samples

Lagha¹

2011

TOCBMJ

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A molecularly imprinted polymer (MIP) was synthesized and evaluated to selectively extract ibuprofen, a nonsteroidal anti-inflammatory drug (NSAID), from human urine. The synthesis of the MIP was performed in dimethylformamide with acrylamide as functional monomer, ethylene glycol dimethacrylate as the cross linker and ibuprofen template as the target drug. The performance of the synthesized MIP as solid phase extraction (SPE) packing to recognize and bind ibuprofen was evaluated against other structurally related NSAIDs such as naproxen and ketoprofen. Using a mixture of acetonitrile-water (1/9 v/v) as a solvent for ibuprofen the binding recovery at approximately 90% was obtained for developed MIP in optimized conditions. Batch rebinding capacity of ibuprofen was determined from the derived Freundlich isotherm and was found to be 1.45 mol g -1 . Furthermore, a higher selectivity of developed MIP for ibuprofen over structurally related analogues was observed. The synthesized MIP has enabled the direct percolation of humane urine and the easy elimination of endogenous compounds from it with simple aqueous washing of the MIP-SPE packing. HPLC analysis has confirmed the high extraction recovery (ca. 85 %) of ibuprofen from such urine samples with use of proposed MIP-SPE system.

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Section: Adsorption Isothermsupporting

confidence: 92%

Section: Adsorption Isothermmentioning

confidence: 99%

A Molecularly Imprinted Polymer for the Selective Solid-Phase Extraction of Ibuprofen from Urine Samples

Lagha¹

2011

TOCBMJ

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“…Data obtained for the Freundlich model concerning MIP and NIP are presented in Table I. The heterogeneity index m obtained for NIP is higher than that of MIP, which is in agreement with previous studies (14,15). As can be seen from the results, the lower m value of MIP indicates a more heterogeneous property than that of NIP.…”

Section: Adsorption Isothermssupporting

confidence: 88%

Preparation and application of a molecularly imprinted polymer for determination of glibenclamide residues

Lahsini¹,

Louhaichi²,

Adhoum³

et al. 2013

Acta Pharmaceutica

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The performance of a molecularly imprinted polymer (MIP) as selective packing material for solid-phase extraction (SPE) of residual glibenclamide in an industrial process was investigated. MIP was prepared using 4-vinylpyridine as monomer, ethylenedimethacrylate as cross linker, 2,2’-azobis-2-methylpropionitrile as initiator and dimethyl formamide as porogen. Use of acetonitrile as a rebinding solvent allows good recognition of the glibenclamide template. It was found that this polymer can be used for determination of trace levels of glibenclamide with a recovery percentage that could reach 87.1 %. Furthermore, the synthesized MIP showed higher selectivity towards glibenclamide than other compounds such as glimepiride and metformine. The synthesized MIP enabled direct determination of the target contaminant after an enrichment step that allowed quantification of glibenclamide at a concentration as low as 0.016 mg L-1. Combination of high performance liquid chromatography with MIP-SPE could be successfully used for quality control of pharmaceuticals during the cleaning process in the production of dry drug forms.

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“…Many other authors have also plotted the measured MIP isotherms on log-log plots [25][26][27][28], but this was done because it was assumed, that the Freundlich isotherm equation fits the experimental data, and the authors wanted to obtain the Freundlich parameters. In the present work Freundlich or any other isotherm equation fitting is not attempted.…”

Section: The Logc -Logq Isotherm Plot and Its Advantagesmentioning

confidence: 99%

Isotherm charts for material selection and method development with molecularly imprinted polymers and other sorbents

Dorkó

Tamás

Horvai

2017

Talanta

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A simple and efficient method is presented for assessing molecularly imprinted polymers (MIP) and other sorbents from the point of view of practical applications. The adsorption isotherms of the compounds, which need to be separated or detected in an application, are constructed from a small number of measured points on a log-log chart and then are compared graphically. Despite its simplicity and robustness this method reveals the information needed for optimal selection between MIPs and alternative sorbents. The design of separation or detection methods with MIPs is also supported by the proposed graphical isotherm comparison. Many experimental isotherms are presented supporting the proposed method.

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Application of the Freundlich adsorption isotherm in the characterization of molecularly imprinted polymers

Cited by 257 publications

References 43 publications

A Molecularly Imprinted Polymer for the Selective Solid-Phase Extraction of Ibuprofen from Urine Samples

A Molecularly Imprinted Polymer for the Selective Solid-Phase Extraction of Ibuprofen from Urine Samples

Preparation and application of a molecularly imprinted polymer for determination of glibenclamide residues

Isotherm charts for material selection and method development with molecularly imprinted polymers and other sorbents

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