Application of the electronic nose for uremia diagnosis

Lin, Yen‐Heng; Guo, Hongru; Chang, Yung‐Hsien; Kao, Min-Tsung; Wang, Hsi-Hua; Hong, Rong-I

doi:10.1016/s0925-4005(01)00625-6

Cited by 115 publications

(64 citation statements)

References 7 publications

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“…It has long been established that smell can be used to diagnose diseases, such as diabetes and uremia (10,20). Pavlou and Turner (15) and Pavlou et al (14,16) were among the first to apply electronic noses in medical diagnostics.…”

Section: Discussionmentioning

confidence: 99%

Prospects for Clinical Application of Electronic-Nose Technology to Early Detection ofMycobacterium tuberculosisin Culture and Sputum

et al. 2006

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Ziehl-Neelsen (ZN) staining for the diagnosis of tuberculosis (TB) is time-consuming and operator dependent and lacks sensitivity. A new method is urgently needed. We investigated the potential of an electronic nose (EN) (gas sensor array) comprising 14 conducting polymers to detect different Mycobacterium spp. and Pseudomonas aeruginosa in the headspaces of cultures, spiked sputa, and sputum samples from 330 cultureproven and human immunodeficiency virus-tested TB and non-TB patients. The data were analyzed using principal-component analysis, discriminant function analysis, and artificial neural networks. The EN differentiated between different Mycobacterium spp. and between mycobacteria and other lung pathogens both in culture and in spiked sputum samples. The detection limit in culture and spiked sputa was found to be 1 ؋ 10 4 mycobacteria ml ؊1 . After training of the neural network with 196 sputum samples, 134 samples (55 M. tuberculosis culture-positive samples and 79 culture-negative samples) were used to challenge the model. The EN correctly predicted 89% of culture-positive patients; the six false negatives were the four ZN-negative and two ZN-positive patients. The specificity and sensitivity of the described method were 91% and 89%, respectively, compared to culture. At present, the reasons for the false negatives and false positives are unknown, but they could well be due to the nonoptimized system used here. This study has shown the ability of an electronic nose to detect M. tuberculosis in clinical specimens and opens the way to making this method a rapid and automated system for the early diagnosis of respiratory infections.

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Section: Discussionmentioning

confidence: 99%

Prospects for Clinical Application of Electronic-Nose Technology to Early Detection ofMycobacterium tuberculosisin Culture and Sputum

et al. 2006

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“…Electronic noses have been applied to various analysis fields such as food [33,34] and various diseases; diabetes [35], uremia [36], asthma [37], chronic obstructive pulmonary disease [38], pulmonary sarcoidosis [39], colorectal cancer [40], and malignant mesothelioma [41,42]. The application of electronic noses to detect lung cancer was also proposed.…”

Section: Discussionmentioning

confidence: 99%

Analysis of volatile organic compounds in exhaled breath for lung cancer diagnosis using a sensor system

Chang

Lee

Ban

et al. 2018

Sensors and Actuators B: Chemical

122

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“…As previously reported with acetone measurement, SIFT-MS offers increased sensitivity and is ideally suited to gases in complex mixtures, able The detector system consisted of six 12MHz quartz crystals coated with synthetic peptides offering different selectivity's and sensitivities (82). The population sampled consisted of healthy individuals as well as those suffering from chronic renal insufficiency (CRI) and chronic renal failure (CRF).…”

Section: Breath Analysis Applied To Renal and Hepatic Diagnosismentioning

confidence: 99%

Breath Analysis for Medical Diagnosis

Hill

Binions

2012

International Journal on Smart Sensing and Intelligent Systems

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The purpose of this review is to highlight the advances in technology and understanding in the field of breath analysis for medical diagnosis. A critical review of the methods of breath collection, treatment, and analysis is given, highlighting the problems facing the field and areas where promising advancement has been made. One particular area of interest is centered around electronic noses, ideally, portable devices which aim to mimic biological olifactory systems in analysing gases to produce odor fingerprints. Furthermore, recent work has shown it is possible to modify the basic sensor materials to both improve their performance, increase their tolerance to factors such as water vapour interferance which often leave the sensor system de-sensitized to the gaseous biomarkers, and enhance their selectivity. It will be shown how it is possible to accurately quantify concentrations of VOC's INTERNATIONAL JOURNAL ON SMART SENSING AND INTELLIGENT SYSTEMS, VOL. 5, NO. 2, JUNE 2012 401 and make disease diagnosis from analysis of the collected data which compare favorably with traditional medical diagnostic techniques.

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Application of the electronic nose for uremia diagnosis

Cited by 115 publications

References 7 publications

Prospects for Clinical Application of Electronic-Nose Technology to Early Detection ofMycobacterium tuberculosisin Culture and Sputum

Prospects for Clinical Application of Electronic-Nose Technology to Early Detection ofMycobacterium tuberculosisin Culture and Sputum

Analysis of volatile organic compounds in exhaled breath for lung cancer diagnosis using a sensor system

Breath Analysis for Medical Diagnosis

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