Application of the Audioscan in the Detection of Carriers of Genetic Hearing Loss

Stephens, Dafydd; Meredith, R.; Sirimanna, Tony; Almqvist, Charlotte; Haugen, Hedda

doi:10.3109/00206099509071902

Cited by 16 publications

(12 citation statements)

References 5 publications

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“…6 Audiological assessment of family members is useful in identifying other affected family members and also in the detection of carriers of genetic hearing impairment. 7 The importance of the geneticists in the management of the hearing impaired child is reflected in our results, with 53% of ENT and 89% of community paediatricians in our study reporting that they routinely refer, or perform genetic tests themselves. Advances in genetics have resulted in the identification of several genes implicated in hearing impairment, particularly connexin 26.…”

Section: Discussionmentioning

confidence: 68%

Aetiological investigation of sensorineural hearing loss in children

Wilson

Roberts

Stephens

2005

Archives of Disease in Childhood

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Section: Discussionmentioning

confidence: 68%

Aetiological investigation of sensorineural hearing loss in children

Wilson

Roberts

Stephens

2005

Archives of Disease in Childhood

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“…This result is in accord with the finding by Stephens et al. , 7 which showed no significant sex effects on Audioscan notches in normally hearing control subjects.…”

Section: The Prevalence Of Audioscan Notches In the Control Subjectsmentioning

confidence: 75%

“…In the study by Stephens et al 7 . on non‐syndromal autosomal recessive hearing impairment, the authors reported that 58% of obligate carriers had significant notches, as did 67% of possible carriers.…”

Section: Clinical Application Of the Audioscan Testmentioning

confidence: 97%

The Audioscan: a high frequency resolution audiometric technique and its clinical applications

Zhao

Stephens

Meyer-Bisch³

2002

Clin Otolaryngol

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The Audioscan is a form of high definition audiometry based on iso-hearing level frequency sweeps, which was developed by Meyer-Bisch in 1990. Compared with traditional tone audiometry, it sweeps across the preset frequency range at a predetermined sweep rate and provides a continuous audiometric curve. Because the device has a maximum frequency range of 125-16 000 Hz with 64 frequencies per octave, the Audioscan method can, theoretically, give 64 times as many values as fixed-frequency audiometry, which may give greater accuracy and sensitivity. An advantage of this is its capacity to detect mild audiometric deficits such as narrow notches situated between the frequencies normally tested. These may represent very limited auditory lesions, at a stage when they cannot be detected by routine audiological methods. Thus, the Audioscan method can give not only a detailed audiometric curve, but also provide important indicators of mild auditory dysfunction. The Audioscan device (e.g. Essilor model) is commercially available for clinical purpose. It is a software-based system, which can also be used for pure tone audiometry and Békésy audiometry. This paper reviews the general aspects of the Audioscan technique and current applications for detecting auditory dysfunction. This would be valuable to provide some guidelines on the Audioscan assessment, and contribute to a clarification of the clinical application of Audioscan and facilitate further research.

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“…Using Audioscan audiometry, notches in the range 500-3,000 Hz have been detected more in the carriers of genetic hearing loss in certain conditions (14,15). Meyer-Bisch (11) considered that the most common zone for genetic disorders seemed to be notches in the 500-3,000 Hz region.…”

Section: Effects Of Age On Audioscan Notches In the Two Groupsmentioning

confidence: 99%

“…The commonest findings are the detection of such narrow notches in the 3,001 to 8,000 Hz zone in individuals exposed to noise or ototoxic substances (12,13). Furthermore, Audioscan notches in the frequency range of 500-3,000 Hz have been shown to be more common in carriers of certain types of genetic hearing impairment (14,15), and also in normally hearing people with tinnitus (16).…”

Section: Introductionmentioning

confidence: 99%

Audioscan Testing in Patients with King-Kopetzky Syndrome

Zhao

Stephens²

1999

Acta Oto-Laryngologica

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In this study, the Audioscan test has been used to detect early signs of hearing abnormalities in 80 patients with King-Kopetzky syndrome. A significantly higher prevalence of Audioscan notches between 500 and 3,000 Hz was found for each age band and gender in patients with King-Kopetzky syndrome than in control subjects. This indicates that Audioscan notches between 500 and 3,000 Hz may represent a fine hearing deficit as an indicator of mild auditory dysfunction in patients with King-Kopetzky syndrome. However, there was no significant difference in the percentage of notches in the 3,001-8,000 Hz frequency band between the King-Kopetzky syndrome and control groups.

show abstract

Application of the Audioscan in the Detection of Carriers of Genetic Hearing Loss

Cited by 16 publications

References 5 publications

Aetiological investigation of sensorineural hearing loss in children

Aetiological investigation of sensorineural hearing loss in children

The Audioscan: a high frequency resolution audiometric technique and its clinical applications

Audioscan Testing in Patients with King-Kopetzky Syndrome

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