Aetiological investigation of sensorineural hearing loss in children

Wilson, Claire; Roberts, Amanda; Stephens, Dafydd

doi:10.1136/adc.2004.049197

Cited by 13 publications

(8 citation statements)

References 8 publications

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“…Their rating of the evidence was described as Grade C, primarily based on expert committee reports, opinions, and clinical experience of respected authorities rather than based on directly applicable studies of good quality. Additionally, a recent survey of otolaryngologists and community pediatricians showed poor adherence to this protocol [22]. Other authors have proposed algorithms which do not address mild or unilateral hearing loss [23].…”

Section: Discussionmentioning

confidence: 99%

Findings from multidisciplinary evaluation of children with permanent hearing loss

Wiley¹,

Arjmand²,

JareenMeinzen-Derr³

et al. 2011

International Journal of Pediatric Otorhinolaryngology

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Section: Discussionmentioning

confidence: 99%

Findings from multidisciplinary evaluation of children with permanent hearing loss

Wiley¹,

Arjmand²,

JareenMeinzen-Derr³

et al. 2011

International Journal of Pediatric Otorhinolaryngology

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“…ARHL is most commonly caused by the damage, loss or death of sensory hearing cells in the cochlea [3], owing to the delicacy of many cochlear tissues, aging results in progressive damage to hair cells and the stria vascularis [4][5][6]. ARHL might also be caused by the damage in the neurons that relay auditory information from the inner ear to the central auditory circuitry [7]. Moreover, damaged cochlear hair cells are practically impossible to repair, so these types of cochlear disorders are currently permanent [6,2,8].…”

Section: Introductionmentioning

confidence: 99%

Screening of key genes and miRNAs involved in age-related hearing loss

song¹,

Zhang²,

Sun³

et al. 2020

Preprint

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Background Age-related hearing loss (ARHL) is the most common sensory deficit and refers to the gradual loss of hearing function with age. We aimed to research the differential expression genes during the occur of ARHL and explore microRNAs that maybe regulate these genes. Methods Search the GEO data GSE6045, GSE35234, GSE62173, GSE45026 from NCBI's Gene Expression Omnibus database, and analyze in R. Normalize GEO data by RMA method in R, and use linear microarray data model (LIMMA) method in R to compare young and old mice to find differential genes and microRNAs. Results 109 up-regulated and 121 down-regulated important genes were identified respectively. Functional enrichment shows that they are significantly enriched in protein digestion and absorption, neuroactive ligand-receptor interaction, and PI3K-Akt signaling pathway. Among the top 20 Hub genes, 7 down-regulated genes (Col3a1, Col1a2, Sparc, Col4a2, Col2a1, Lox, Sparc, Ctgf) have verified targeted miRNAs, which have interaction with differential miRNAs of GSE45026. Finally, we designated miR-29a-3p, miR-29b-3p, miR-29c-3p, and miR-124-3p as key miRNAs involved in the development of age-related hearing loss. Conclusions These low expression genes of Col3a1, Col1a2, Sparc, Col4a2, Col2a1,Lox, Sparc, and Ctgf maybe key genes of ARHL, and probably regulated by miR-29a-3p, miR-29b-3p, miR-29c-3p, and miR-124-3p.

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“…There is little evidence on adherence to the guidelines across the country. Wilson et al 4 studied the current practice of aetiological investigation of children with bilateral severe-to-profound sensorineural hearing loss (SNHL) in Wales by sending postal questionnaires to all ear, nose and throat (ENT) consultants and community paediatricians in audiology working in Wales. They found that community paediatricians reported higher usage of visual and developmental assessment, but less of imaging and ECG, whereas ENT consultants were less likely than other specialists to request ECG and urine analysis.…”

Section: Introductionmentioning

confidence: 99%

Deafness in children: a national survey of aetiological investigations

Rangan¹,

Borgstein

Lowe

2012

BMJ Open

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ObjectiveThe aim of this study was to obtain national data regarding adherence to national guidelines for aetiological investigations for hearing loss in children and highlight any variations in practice. Information was also collected on possible factors affecting lack of adherence.DesignAn online questionnaire based on the national guidelines for aetiological investigations for deafness was designed.SettingThe questionnaire was distributed to the leads of all the Newborn Hearing Screening Programme (NHSP) sites across England through the Medical Research Council Hearing & Communication Group.ParticipantsThe questionnaire was sent to 100 recipients; from this 52 responses were obtained.Outcome measuresVariability in the investigations offered for hearing loss.ResultsThere was a 52% response rate. Analysis of the responses showed that audiovestibular physicians and paediatricians in audiology were more likely than other specialists to request level 1 investigations (investigations that are recommended to be offered in all cases). Respondents from London and the North West were more likely to request level 1 investigations compared with those from other regions. In all, 14 of the 19 audiovestibular physicians and paediatricians in audiology requested level 1 investigations routinely, but only 11 of 33 from other specialties did likewise. Of the 20 respondents from London and the Northwest, 15 requested level 1 investigations routinely, whereas only 10 of the 32 respondents from the other regions did the same. The difference was statistically significant in both cases. The geographical variation was specially marked for family audiograms and MRI.ConclusionsThere is significant variation from the national guidelines in requesting aetiological investigations for permanent hearing impairment (PHI) in children, depending on the specialty of the clinician and the geographical region, these variations appear partly to be due to the availability of local resources but also due to lack of awareness of the importance of some investigations.

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Aetiological investigation of sensorineural hearing loss in children

Cited by 13 publications

References 8 publications

Findings from multidisciplinary evaluation of children with permanent hearing loss

Findings from multidisciplinary evaluation of children with permanent hearing loss

Screening of key genes and miRNAs involved in age-related hearing loss

Deafness in children: a national survey of aetiological investigations

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