Application of Stereotactic Radiosurgery to the Head and Neck Region

Bajada, C L; Selch, Michael T.; Salles, Antônio De; Goetsch, Steven J.; Juillard, G; Solberg, T.D.; Parker, Robert G.

doi:10.1007/978-3-7091-9371-6_24

Cited by 22 publications

(5 citation statements)

References 19 publications

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“…Kondziolka and Lusford 8 first applied SRS with a gamma unit to the treatment of previously irradiated nasopharyngeal tumor. Some investigators also used linear accelerator‐based SRS for the treatment for these lesions 6,9,10,12 . Cmelak et al 12 reported that 7 of 12 lesions in eight patients were successfully treated.…”

Section: Discussionmentioning

confidence: 99%

“…Stereotactic radiosurgery is used increasingly for extracranial lesions because of a rapid fall‐off in dose deposition at the edge of the small target volume 6–13 . Kondziolka and Lusford 8 first applied SRS with a gamma unit to the treatment of previously irradiated nasopharyngeal tumor.…”

Section: Discussionmentioning

confidence: 99%

“…The stereotactic irradiation procedure, which delivers focused irradiation to small target volumes, had been limited to single fraction treatment, stereotactic radiosurgery (SRS), but with the development of a relocatable immobilization system to precisely reproduce the patient's position at each treatment, fractionated stereotactic radiation therapy (SRT) became a new modality that combines the accurate focal dose delivery of SRS with the biologic advantages of conventional radiotherapy. Although most of the early application of SRS concentrated on the treatment of brain disease, recently SRS has shown its potential in extracranial lesions including skull base lesions with the use of a relocatable fixation device 6–13 …”

Section: Introductionmentioning

confidence: 99%

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Stereotactic radiotherapy for locally recurrent nasopharyngeal carcinoma

et al. 1999

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Objective: To determine the efficacy of stereotactic radiotherapy (SRT) in the treatment of recurrent nasopharyngeal carcinoma. Study Design: A retrospective review of the outcome of SRT for patients with recurrent nasopharyngeal carcinomas following definitive conventional radiation therapy. Methods: Five patients were treated with daily static multiportal irradiation. Two Gy was administered with eight isocentric portals in a single plane 5 days a week, and the plane was changed for every 20 to 30 Gy. Of these patients, three had poorly differentiated squamous cell carcinoma. Tumor sizes ranged from 1 to 15 cm3, with a median size 3.2 cm3. Median follow‐up time from SRT was 34 months (range, 4–61 mo). Results: Four of five recurrent tumors responded well and achieved complete regression. Three patients have survived without evidence of local recurrence with a median follow‐up time of 34 months. Marginal recurrence was observed at the posterosuperior wall in a patient with adenoid cystic carcinoma at 30 months after SRT. One patient who received SRT after the two complete courses of radiation therapy died 6 months after SRT as a result of rupture of a branch of the left carotid artery, but autopsy revealed no local residual tumor. Conclusions: Stereotactic radiotherapy with isocentric multiportals in one plane, which is changed at every 20 to 30 Gy, can provide local control with acceptable toxicity in patients with recurrent nasopharyngeal carcinoma, but increased clinical experience and longer follow‐up will be necessary to evaluate the overall role of this technique in nasopharyngeal carcinoma.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Stereotactic radiotherapy for locally recurrent nasopharyngeal carcinoma

et al. 1999

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“…2 Tumor recurred at the edge of the treatment field to the outside. 3 Died from pneumonia and bone metastases. 4 Died from pneumonia.…”

Section: Discussionmentioning

confidence: 99%

Stereotactic Radiosurgery as a Salvage Treatment for Recurrent Epipharyngeal Carcinoma

Oda

Mori

Kobayashi

et al. 2006

Stereotact Funct Neurosurg

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Fourteen patients with recurrent epipharyngeal carcinoma (EPC) were treated by gamma knife stereotactic radiosurgery. The tumor volume ranged from 0.3 to 80 ml (median 18.9 ml). Treatment was done with a tumor margin dose of 10–27 Gy (median 15 Gy). The median follow-up period was 15 months (range 2–47 months). Ten patients were alive and 4 were dead at the end of the follow-up period. In 6 patients (43%), the tumor disappeared or decreased in size until the end of the follow-up period. In 2 (14%), the tumor remained unchanged in size. In 6 (43%), the tumor showed regression initially but was enlarged later. A second radiosurgery was performed in 4 of those 6 cases and the tumor decreased in size again in 3 of them. Thus, the overall control rate of local tumor was 79% (11/14). In selected patients with recurrent EPC, stereotactic radiosurgery can be considered as a salvage treatment producing local control.

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“…S tereotactic body radiotherapy (SBRT) typically consists of a relatively small number of high-dose fractions delivered to extracranial targets and reports of its use date back to the early 1990s. [1][2][3] Since then, it has become accepted as an effective treatment for patients with medically inoperable early-stage peripheral non-small-cell lung cancer (NSCLC) and its introduction throughout The Netherlands has been associated with improvements in population-based outcomes for early-stage NSCLC. [4][5][6] Despite the fact that follow-up has been of limited duration, and lower rates of pathological confirmation of malignancy have been obtained in some SBRT series, recent analyses suggest that SBRT may achieve local and regional control rates that are comparable with surgery in early-stage NSCLC.…”

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confidence: 99%