Application of steam carrier gas chromatography to analyses of pharmaceuticals; I. Determination of salicylic acid and phenol in pharmaceutical preparations in the Japanese Pharmacopoeia X.

A gas chromatography method using steam as the carrier gas was established for the determination of salicylic acid in plasma. A 0.5 mL plasma sample was mixed with 0.5 mL of 6N HCl and then extracted with 2 mL of dichloromethane. The dichloromethane was evaporated to dryness and the residue was redissolved in 0.5 mL of water and then analysed by gas chromatography using steam as the carrying gas. The result was calculated by external standardization.

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Simultaneous Determination of Three Species by Flow Injection Analytical Method Using Enzyme-Immobilized Open-Tubular Reactors

Morishita

Nishikawa

Kojima

1986

ANAL. SCI.

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A simultaneous determination of three species by a flow injection analytical (FIA) method using enzyme-immobilized open-tubular reactors in parallel is described. The design of the optimal geometry of the FIA system is especially important to avoid overlap of any pairs of peaks. Ours was carried out based on the Taylor-Aris equation. Despite a somewhat complex splitting-confluence flow system, reproducible results were obtained in the simultaneous determination of L-lactate, f3-D-glucose and glycerol by the detection of the resulting common product, NADH. Assignment of the enzyme reactors to the channels should be made by taking into account the concentration ranges of the analytes to be measured and the differences in the rates of individual enzyme reactions.

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Application of steam carrier gas chromatography to analyses of pharmaceuticals; I. Determination of salicylic acid and phenol in pharmaceutical preparations in the Japanese Pharmacopoeia X.

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Analytical methods for alcohols, phenols, ethers and peroxides

Analytical methods for alcohols, phenols, ethers and peroxides

Determination of salicylic acid in plasma by gas chromatogrphy using steam as carrier gas

Simultaneous Determination of Three Species by Flow Injection Analytical Method Using Enzyme-Immobilized Open-Tubular Reactors

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