Application of SPOT chip for transcutaneous oximetry

Kmiec, Maciej M.; Hou, Huagang; Kuppusamy, M. Lakshmi; Drews, Thomas; Prabhat, Anjali M.; Petryakov, Sergey; Demidenko, Eugene; Schaner, Philip E.; Buckey, Jay C.; Blank, Aharon; Kuppusamy, Periannan

doi:10.1002/mrm.27667

Cited by 4 publications

(2 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…1 Our laboratory has developed a variety of EPR oxygen-sensing probes, collectively known as OxyChips, for an assortment of clinical applications. [2][3][4][5][6] The OxyChip is fabricated by embedding oxygen-sensitive microcrystals of lithium octan-butoxy-naphthalocyanine (LiNc-BuO) 7,8 in polydimethylsiloxane (PDMS) polymer. 3,9 Embedding the LiNc-BuO microcrystals in PDMS shields them from interaction with the biological milieu, preserves the localization and concentration of the crystals once implanted, and provides the structural integrity of the OxyChip.…”

Section: Introductionmentioning

confidence: 99%

“…Electron paramagnetic resonance (EPR) oximetry is a very effective method for measuring the absolute value of tissue oxygen concentration (pO 2 ) directly and repeatedly 1 . Our laboratory has developed a variety of EPR oxygen‐sensing probes, collectively known as OxyChip s, for an assortment of clinical applications 2–6 . The OxyChip is fabricated by embedding oxygen‐sensitive microcrystals of lithium octa‐ n ‐butoxy‐naphthalocyanine (LiNc‐BuO) 7,8 in polydimethylsiloxane (PDMS) polymer 3,9 .…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

OxyChip embedded with radio‐opaque gold nanoparticles for anatomic registration and oximetry in tissues

Kmiec

Hebert

Tse

et al. 2021

Magnetic Resonance in Med

Self Cite

View full text Add to dashboard Cite

Purpose: Electron paramagnetic resonance oximetry using the OxyChip as an implantable oxygen sensor can directly and repeatedly measure tissue oxygen levels. A phase I, first-in-human clinical study has established the safety and feasibility of using OxyChip for reliable and repeated measurements of oxygen levels in a variety of tumors and treatment regimens. A limitation in these studies is the inability to easily locate and identify the implanted probes in the tissue, particularly in the long term, thus limiting spatial/anatomical registration of the implant for proper interpretation of the oxygen data. In this study, we have developed and evaluated an enhanced oxygen-sensing probe embedded with gold nanoparticles (GNP), called the OxyChip-GNP, to enable visualization of the sensor using routine clinical imaging modalities. Methods:In vitro characterization, imaging, and histopathology studies were carried out using tissue phantoms, excised tissues, and in vivo animal models (mice and rats). Results:The results demonstrated a substantial enhancement of ultrasound and CT contrast using the OxyChip-GNP without compromising its electron paramagnetic resonance and oxygen-sensing properties or biocompatibility. Conclusions:The OxyChips embedded with gold nanoparticles (OxyChip-GNP) can be readily identified in soft tissues using standard clinical imaging modalities such as CT, cone beam-CT, or ultrasound imaging while maintaining its capability to make repeated in vivo measurements of tissue oxygen levels over the long term. This unique capability of the OxyChip-GNP facilitates precisely localized in vivo oxygen measurements in the clinical setting.

show abstract