In this review paper, a complete study and analysis of the research articles dealing with the removal of various organic and inorganic pollutants using solvent impregnated resins (SIR) is carried out. The method of impregnation, characterizations of prepared resin, and regeneration techniques of different SIRs for batch and continuous fixed bed columns are presented. The effects of different operating parameters (e.g., loading of solvent on the resin, dosage of adsorbent, initial solute concentration, pH, temperature, time, ionic strength) on the separation efficiency of SIR in the batch mode are discussed. Thermodynamic parameters (change in Gibbs free energy, enthalpy, and entropy) are tabulated from the data available in the literature, and if not given, then their values are calculated and presented. The influence of parameters (flow rate, bed height, pH, concentration of the solution, etc.) on the fixed bed column performance is analyzed. Design aspects of the column are also discussed, and the dimensions of fixed bed columns for industrial applications are proposed.