Application of silver oxide nanoparticles for the treatment of cancer

Iqbal, Seemab; Fakhar-e-Alam, M.; Akbar, Fozia; Shafiq, Muhammad; Atif, M.; Amin, Nasir; Ismail, Muhammad; Hanif, Atif; Farooq, W. A.

doi:10.1016/j.molstruc.2019.04.041

Cited by 65 publications

(27 citation statements)

References 23 publications

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“…Thus, the presence of structural defects (oxygen vacancies) in the crystal structure of Mn-doped metal oxides nanostructures leads to increased ROS generation ( Abbas et al, 2015 , Abbas et al, 2015 , Iqbal et al, 2019 ). We previously observed a similar relation for Fe-doped CeO 2 ; however, no such a connection has been found in the case of Co-doped CeO 2 NPs ( Iqbal et al, 2019 , Iqbal et al, 2019 ). Hence, further investigation is needed.…”

Section: Discussionmentioning

confidence: 57%

Manganese-doped cerium oxide nanocomposite as a therapeutic agent for MCF-7 adenocarcinoma cell line

Atif

Iqbal²,

Fakhar-e-Alam³

et al. 2021

Saudi Journal of Biological Sciences

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The preparation of a manganese-doped cerium oxide (Mn:CeO 2 ) nanocomposite via hydrothermal route is described. Cubic fluorite structure of single phase was exhibited by studying structural analysis through x-ray diffraction (XRD) technique and morphological analysis was conducted by scanning electron microscope. Surface analytic technique of energy dispersive x-ray spectroscopy (EDX) was conducted to analyze the relative amount of any impurity and doping. Structural changes due to manganese doping such as increment in production of vacancies of oxygen within crystal of cerium oxide, and reduction in size of crystallite and constant of lattice was observed in our research study. Moreover, the Mn:CeO 2 nanocomposite demonstrates differential cytotoxicity against MCF-7 adenocarcinoma cell line, which renders it a promising candidate for targeted cancer therapy. The anti-tumorous activity of the cerium oxide nanocomposite was significantly enhanced with doping of manganese, which is directly linked with the generation of highly reactive oxygen facets. The experimental results are supported by a mathematical model that confirms a confidence level of 95%. This research has paved the way for many utilities in therapeutics and magnetic resonance imaging diagnostics through new observations, and hence verified their math model.

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Section: Discussionmentioning

confidence: 57%

Manganese-doped cerium oxide nanocomposite as a therapeutic agent for MCF-7 adenocarcinoma cell line

Atif

Iqbal²,

Fakhar-e-Alam³

et al. 2021

Saudi Journal of Biological Sciences

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“…The MCF-7 cell line has been used to evaluate the effect of doping and the dose-dependent toxicity of Mn x Ce 1− x O 2 nanocomposites [1, 29, 33]. A red light array with a wavelength of 650 nm was used to excite the 5-ALA/PpIX drug to observe the photodynamic effect.…”

Section: Resultsmentioning

confidence: 99%

Manganese-Doped Cerium Oxide Nanocomposite Induced Photodynamic Therapy in MCF-7 Cancer Cells and Antibacterial Activity

Atif

Iqbal

Fakhar-e-Alam

et al. 2019

BioMed Research International

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In this experimental approach, we explored the structures, morphologies, phototoxicities, and antibacterial activities of undoped and Mn-doped ceria nanocomposite materials, MnxCe1−xO2. The MnxCe1−xO2 nanocomposites were synthesized by employing a soft chemical route. Our prime focus was on the influence of different factors, both physical and chemical, i.e., the concentration of manganese in the product, size of the nanocomposite, drug dose, and incubation time, on the bacterial strains. Different bacterial strains were selected as experimental biological models of the antibacterial activity of the manganese-doped cerium oxide nanocomposite. In addition to the photodynamic response, the adenocarcinoma cell line (MCF-7) was also studied. Based on cell viability losses and bacterial inhibition analyses, the precise mechanisms of apoptosis or necrosis of 5-ALA/PpIX-exposed MCF-7 cells under 630 nm red lights and under dark conditions were elucidated. It was observed that the undoped nanocomposites had lower cytotoxicities and inhibitions compared with those of the doped nanocomposites towards pathogens. The antibacterial activity and effectiveness for photodynamic therapy were enhanced in the presence of the manganese-doped ceria nanocomposite, which could be attributed to the correlation of the maximum reactive oxygen species generation for targeted toxicity and maximum antioxidant property in bacteria growth inhibition. The optimized cell viability dose and doping concentration will be beneficial for treating cancer and bacterial infections in the future.

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“…Boehmite (AlOOH) can be used as an adjuvant for vaccines [30,31]. Silver oxide (Ag 2 O) NPs have the potential for diagnostic biological probes [32], and antibacterial and anticancer agents [33][34][35].…”

Section: Introductionmentioning

confidence: 99%

Effects of Metal Oxide Nanoparticles on Toll-Like Receptor mRNAs in Human Monocytes

et al. 2020

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For the widespread application of nanotechnology in biomedicine, it is necessary to obtain information about their safety. A critical problem is presented by the host immune responses to nanomaterials. It is assumed that the innate immune system plays a crucial role in the interaction of nanomaterials with the host organism. However, there are only fragmented data on the activation of innate immune system factors, such as toll-like receptors (TLRs), by some nanoparticles (NPs). In this study, we investigated TLRs’ activation by clinically relevant and promising NPs, such as Fe3O4, TiO2, ZnO, CuO, Ag2O, and AlOOH. Cytotoxicity and effects on innate immunity factors were studied in THP-1(Tohoku Hospital Pediatrics-1) cell culture. NPs caused an increase of TLR-4 and -6 expression, which was comparable with the LPS-induced level. This suggests that the studied NPs can stimulate the innate immune system response inside the host. The data obtained should be taken into account in future research and to create safe-by-design biomedical nanomaterials.

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Application of silver oxide nanoparticles for the treatment of cancer

Cited by 65 publications

References 23 publications

Manganese-doped cerium oxide nanocomposite as a therapeutic agent for MCF-7 adenocarcinoma cell line

Manganese-doped cerium oxide nanocomposite as a therapeutic agent for MCF-7 adenocarcinoma cell line

Manganese-Doped Cerium Oxide Nanocomposite Induced Photodynamic Therapy in MCF-7 Cancer Cells and Antibacterial Activity

Effects of Metal Oxide Nanoparticles on Toll-Like Receptor mRNAs in Human Monocytes

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