2017
DOI: 10.21577/0103-5053.20170080
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Application of Response Surface Modeling and Chemometrics Methods for the Determination of Ofloxacin in Human Urine Using Dispersive Liquid-Liquid Microextraction Combined with Spectrofluorimetry

Abstract: Dispersive liquid-liquid microextraction (DLLME) and spectrofluorimetry, coupled with chemometrics methods, are proposed in this work for the pre-concentration and determination of ofloxacin concentration in spiked human urine. Chloroform and acetonitrile were selected as the extraction and dispersive solvents by the one-variable-at-a-time process. The Box-Behnken design was used to optimize the other variables, including the volume of extraction and dispersion solvents, solution pH, and ionic strength. A line… Show more

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Cited by 3 publications
(5 citation statements)
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“…In this study analytes were detected with LODs ranging from 0.2 to 2 ng/ml (Odoardi et al, 2015). Assadian and Niazi (2017) One year later Kaykhaei et al (2018) demonstrated DLLME combined with microvolume spectrophotometry to study iodine in urine samples. They used toluene as an extracting phase and ethanol as a dispersive solvent.…”
Section: Dispersive Liquid-liquid Microextractionmentioning
confidence: 75%
“…In this study analytes were detected with LODs ranging from 0.2 to 2 ng/ml (Odoardi et al, 2015). Assadian and Niazi (2017) One year later Kaykhaei et al (2018) demonstrated DLLME combined with microvolume spectrophotometry to study iodine in urine samples. They used toluene as an extracting phase and ethanol as a dispersive solvent.…”
Section: Dispersive Liquid-liquid Microextractionmentioning
confidence: 75%
“…Due to the low concentration of the analytes and the complex matrix of the samples, a preliminary sample preconcentration and a separation technique are required. Thus, different extraction processes have been used for separation and pre-concentration of trace pesticide residues, such as solid phase extraction method (SPE) [8][9][10][11], solid phase microextraction (SPME) [12], [13], single drop microextraction (SDME) [14] and dispersive liquid-liquid microextraction (DLLME) [15][16][17].…”
Section: Introductionmentioning
confidence: 99%
“…One of the most popular LPME techniques is dispersive liquid-liquid microextraction (DLLME) which is widely used as a preconcentration method [18][19][20][21]. DLLME was developed by Assadi and co-workers [16]. By consisting of the formation of a cloudy solution promoted by the fast addition in the aqueous sample of a mixture of extractor and dispersive solvents.…”
Section: Introductionmentioning
confidence: 99%
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