Application of QuEChERS based method for the determination of pesticides in nutraceutical products (Camellia sinensis) by liquid chromatography coupled to triple quadrupole tandem mass spectrometry

Martínez-Domínguez, Gerardo; Nieto-García, Antonio José; Romero‐González, Roberto; Frenich, Antonia Garrido

doi:10.1016/j.foodchem.2015.01.032

Cited by 41 publications

(14 citation statements)

References 16 publications

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“… 28 − 31 Several dispersive adsorbents (PSA, C18, GCB, SAX, florisil, carbon nanotubes) have been previously reported for removal of tea matrix as D-SPE adsorbents. 8 , 32 − 38 In this study, PSA, C18, and MWCNTs were prepared for cleanup in the mixture of IS-D-SPE adsorbents, and each mass of adsorbents was optimized. To evaluate the recovery and cleanup effects, blank extracts spiked with 117 pesticides at 25 μg L –1 were investigated using different adsorbents.…”

Section: Resultsmentioning

confidence: 99%

Multiresidue Method for the Rapid Determination of Pesticide Residues in Tea Using Ultra Performance Liquid Chromatography Orbitrap High Resolution Mass Spectrometry and In-Syringe Dispersive Solid Phase Extraction

et al. 2017

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A method based on in-syringe dispersive solid phase extraction (IS-D-SPE) and ultra performance liquid chromatography Orbitrap high resolution mass spectrometry for the multiresidue analysis of 117 pesticides in tea was developed. Full scan mode was acquired over an m/z range of 100–800 with Orbitrap resolution at 70000, followed by full scan/dd-MS2 mode for confirmation. The identification criteria of retention time and mass accuracy tolerance was ±0.20 min and ±5.0 ppm, respectively. MS/MS fragment ions obtained dd-MS2 were necessary to identify the pesticides with the same molecular mass weight. The IS-D-SPE technique involved a mixture of 200 mg PSA, 100 mg C18, and 15 mg multiwalled carbon nanotubes for the cleanup of tea matrix. Good linearity (R2 > 0.99) for 117 pesticides was obtained. Satisfactory recoveries in the range of 70–120% were obtained for 105 pesticides, while intraday and interday precisions were below 20%. Limits of quantification were generally 10 μg kg–1. Finally, this method was employed to analyze 117 pesticides in 70 tea samples.

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Section: Resultsmentioning

confidence: 99%

Multiresidue Method for the Rapid Determination of Pesticide Residues in Tea Using Ultra Performance Liquid Chromatography Orbitrap High Resolution Mass Spectrometry and In-Syringe Dispersive Solid Phase Extraction

et al. 2017

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“…Among neonicotinoids, TCP is one of the most commonly used, and it belongs to the so-called “first generation” neonicotinoids. The usual analytical methods for TCP quantitation in food samples use liquid chromatography [4,5,6,7,8]. In particular, HPLC-MS/MS [9,10] and UHPLC-MS/MS [11,12] have been reported for their determination in lettuce.…”

Section: Introductionmentioning

confidence: 99%

Automated Photochemically Induced Method for the Quantitation of the Neonicotinoid Thiacloprid in Lettuce

et al. 2019

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In this work, we present an automated luminescence sensor for the quantitation of the insecticide thiacloprid, one of the main neonicotinoids, in lettuce samples. A simple and automated manifold was constructed, using multicommutated solenoid valves to handle all solutions. The analyte was online irradiated with UV light to produce a highly fluorescent photoproduct (λexc/λem = 305/370 nm/nm) that was then retained on a solid support placed in the flow cell. In this way, the pre-concentration of the photoproduct was achieved in the detection area, increasing the sensitivity of the analytical method. A method-detection limit of 0.24 mg kg−1 was achieved in real samples, fulfilling the Maximum Residue Limit (MRL) of The European Union for thiacloprid in lettuce (1 mg kg−1). A sample throughput of eight samples per hour was obtained. Recovery experiments were carried out at values close to the MRL, obtaining recovery yields close to 100% and relative standard deviations lower than 5%. Hence, this method would be suitable for routine analyses in quality control, as an alternative to other existing methods.

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“…introduced an attractive sample preparation method in fruits and vegetables, called QuEChERS, based on the Mills method, the Luke method, and the Becker method . This pretreatment method was very flexible and widely applied for the determination of multiple pesticide residues in agricultural products . The QuEChERS method is a sample preparation technique entailing solvent extraction with acetonitrile, acetone, or other organic solvents and phase separation with magnesium sulfate alone or in combination with other salts, generally sodium chloride (NaCl); this process is followed by a clean‐up procedure using dispersive solid‐phase extraction (d‐SPE), adding small amounts of bulk SPE sorbents to the extract.…”

Section: Introductionmentioning

confidence: 99%

Simultaneous determination of 35 ultra‐trace level organophosphorus pesticide residues in Sanjie Zhentong capsules of traditional Chinese medicine using ultra high performance liquid chromatography with tandem mass spectrometry

Li²,

Wu³

et al. 2017

J of Separation Science

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The aim of this study was to develop an analytical method for the simultaneous determination of ultra-trace levels of 35 organophosphorus pesticide residues in Sanjie Zhentong capsules, a traditional Chinese medicine prescription. A method based on multiclass and multiresidue sample preparation was developed. First, samples were hydrated with water at 4°C. A ratio of 1:3 sample/water was used for each of the sample amounts. Then, different extraction solvents were screened. This step was followed by a dispersive solid-phase extraction clean-up procedure using both primary secondary amine and polyamide. A comprehensive sensitive multiresidue liquid chromatography tandem mass spectrometry method was investigated and validated. Good linearity was achieved in the range of 10-500 μg/kg for each analyte. The average recovery ranged from 70 to 120%, except for methamidophos, fonophos, diazinon, and chlorpyriphos-ethyl, the recoveries of which ranged from 60-70% at the lower concentration level. The precision values were lower than 10% for all the compounds in three concentration levels. The limits of detection and limits of quantification values were 0.01-2.1 and 0.05-3.4 μg/kg, respectively. The matrix effects were determined, and most of the compounds showed signal suppression. Finally, this optimized procedure was applied for the analysis of real samples.

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Application of QuEChERS based method for the determination of pesticides in nutraceutical products (Camellia sinensis) by liquid chromatography coupled to triple quadrupole tandem mass spectrometry

Cited by 41 publications

References 16 publications

Multiresidue Method for the Rapid Determination of Pesticide Residues in Tea Using Ultra Performance Liquid Chromatography Orbitrap High Resolution Mass Spectrometry and In-Syringe Dispersive Solid Phase Extraction

Multiresidue Method for the Rapid Determination of Pesticide Residues in Tea Using Ultra Performance Liquid Chromatography Orbitrap High Resolution Mass Spectrometry and In-Syringe Dispersive Solid Phase Extraction

Automated Photochemically Induced Method for the Quantitation of the Neonicotinoid Thiacloprid in Lettuce

Simultaneous determination of 35 ultra‐trace level organophosphorus pesticide residues in Sanjie Zhentong capsules of traditional Chinese medicine using ultra high performance liquid chromatography with tandem mass spectrometry

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