Application of pressurized liquid extraction technology to pharmaceutical solid dosage form analysis

RP-HPLC-PDA Method for Simultaneous Quantification of Montelukast, Acebrophylline and Desloratadine Tablets

“…Literature review indicates that few analytical methods like spectrophotometric [3], HPLC [4][5][6][7] and LC-MS [8] have been reported for the quantification of montelukast with other drugs. Acebrophylline ( Fig.1) chemically is 4-[2-amino-3,5-dibromophenyl)methylamino]cyclohexan-1-ol; 2-(1,3-dimethyl-2,6-dioxopurin-7-yl)acetic acid.…”

Derivative spectrophotometry method for simultaneous estimation of rupatadine and montelukast in their combined dosage form

“…[1][2] Montelukast is a specifi c cysteinyl leukotriene receptor antagonist belonging to a styryl quinolines series with the chemical name 2-[1-[1(R)-[3-[2(E)-(7-chloroquinolin-2yl) vinyl] phenyl]-3[2-(1-hydroxy-1-methylethyl) phenyl] propylsulfanylmethyl] cyclo-propyl] acetic acid sodium salt. sodium include HPLC, [5] protein precipitation, [6] liquid chromatography/tandem mass spectrometry(LC-MS/ MS), [7] liquid-liquid extraction using HPLC with the fl uorescence detector, [8] its S-enantiomer in human plasma by stereoselective high performance liquid chromatography (HPLC) using column-switching [9] and its determination in human plasma by the column-switching HPLC method, [10] derivative spectroscopy, HPLC, [11] microwaveassisted extraction (MAE) technique, [12] method for the application of pressurized liquid extraction technology for pharmaceutical solid dosage form [13] Residual acetate analysis in bulk drug. [14] No spectrophotometric method or the HPLC method has been reported in the literature for the simultaneous determination of montelukast and rupatadine in their commercial formulations.…”

Leveraging elevated temperature and particle size reduction to extract API from various tablet formulations

“…Increased temperature accelerates the extraction kinetics, and elevated pressure keeps the solvent below its boiling point enabling safe and rapid extractions. ASE has been used for assay and content uniformity determination for pharmaceutical dosage forms, including extended release tablets [2,3], chewable tablets [4,5], and transdermal patches [3,6]. As an example, Hoang et al [5] used ASE to extract an LTD4 antagonist from a chewable tablet formulation for content uniformity analysis.…”

“…ASE has been used for assay and content uniformity determination for pharmaceutical dosage forms, including extended release tablets [2,3], chewable tablets [4,5], and transdermal patches [3,6]. As an example, Hoang et al [5] used ASE to extract an LTD4 antagonist from a chewable tablet formulation for content uniformity analysis. Intact tablets were first exposed to water at 40 • C to disperse the tablet, then to methanol at 70 • C to extract the drug.…”