Application of polymer gels containing side‐chain phosphate groups to drug‐delivery contact lenses

Sato, Takao; Uchida, Rei; Tanigawa, Haruyasu; Uno, Kenji; Murakami, Akira

doi:10.1002/app.22080

Cited by 90 publications

(46 citation statements)

References 49 publications

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“…Soft contact lens-based DDSs have been investigated by several approaches: (1) Soak and absorption of drug solution [86]; (2) piggyback contact lens combined with a drug plate or drug solution [87]; (3) surface-modification to immobilize drugs on the surface of contact lenses [88]; (4) incorporation of drugs in a colloidal structure dispersed in the lens [89]; (5) ion ligand-containing polymeric hydrogel [90]; and (6) molecularly imprinting of drugs [91,92].…”

Section: Contact Lensmentioning

confidence: 99%

Recent Advances in Ocular Drug Delivery Systems

2011

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Abstract:Transport of drugs applied by traditional dosage forms is restricted to the eye, and therapeutic drug concentrations in the target tissues are not maintained for a long duration since the eyes are protected by a unique anatomy and physiology. For the treatment of the anterior segment of the eye, various droppable products to prolong the retention time on the ocular surface have been introduced in the market. On the other hand, direct intravitreal implants, using biodegradable or non-biodegradable polymer technology, have been widely investigated for the treatment of chronic vitreoretinal diseases. There is urgent need to develop ocular drug delivery systems which provide controlled release for the treatment of chronic diseases, and increase patient's and doctor's convenience to reduce the dosing frequency and invasive treatment. In this article, progress of ocular drug delivery systems under clinical trials and in late experimental stage is reviewed.

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Section: Contact Lensmentioning

confidence: 99%

Recent Advances in Ocular Drug Delivery Systems

2011

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“…[17][18][19] In previous studies, a drug delivery hydrogel material consisting of 2-hydroxyethyl methacrylate (HEMA) was used as the main material, ethyleneglycole dimethacrylate (EGDMA) as a crosslinking agent, methacrylamide (MAm) as a functional group, and methacrylic acid or phosphoric acid as an anionic material group. 17,18 The polymer-drug interaction between phosphoric acid as an anionic material, and naphazoline as a cationic drug 19 was also studied, and it was found that HEMA, EGDMA, and MAm were required, since both cationic and anionic monomers are essential to a synthesized drug delivery hydrogel SCL. The reason for this is that the hydrogel material is not able to maintain the strength and the shape necessary for an SCL if either a cationic or anionic monomer was not included.…”

mentioning

confidence: 99%

Development and Efficacy of a Drug-Releasing Soft Contact Lens

Kakisu

Matsunaga²,

Kobayakawa

et al. 2013

Invest. Ophthalmol. Vis. Sci.

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PURPOSE. The purpose of this study was to investigate the uptake and the release of antibiotics from a newly synthesized drug delivery hydrogel soft contact lens (SCL) using an ion ligand mechanism.METHODS. The antibiotics used were Gatifloxacin (GFLX) and Moxifloxacin (MFLX). The uptake amount and the sustained-release kinetics of antibiotics were investigated in vitro, and were also compared with newly synthesized SCLs, etafilcon A and polymacon. The antibiotic concentrations in the cornea, aqueous humor, and crystalline lens, and the effect against bacterial proliferation were investigated in vivo using rabbit subjects. Additionally the drug release efficacy of the new SCL was compared with that of eye drop administrations.RESULTS. In vitro, antibiotic uptake was increased with the weight percent (wt%) of the anionic group, and the released amount of antibiotics was highest during the initial 1 hour period, which then decreased over the next 72 hours. The released antibiotics volume of the new SCLs was significantly higher throughout 72 hours than that of the other two materials, etafilcon A and polymacon (P < 0.01). Whereas in vivo, the concentrations found in the cornea and aqueous humor were higher than those for the eye drop groups (P < 0.05 or P < 0.01). Antibiotic release at those sites decreased over 72 hours. No bacterial populations were detectable in the group treated with the new SCL presoaked in antibiotics throughout the experimental periods. CONCLUSIONS.The new SCLs released the antibiotics over several days, and showed improved penetration into the eye, along with prevention of bacterial proliferation.

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“…[11][12][13] For instance, the hydrogels containing the comonomers methacrylic acid (MAA) or NVP (N-vinyl pyrrolidone) has been shown to be capable for a large amount of water. [14][15][16][17] The HEMA that has been copolymerized with anionic monomers such as MAA to introduce charged moieties in the polymeric network was found to improve the biological performance of the material. 10,18 For that reason, HEMA-MAA hydrogels are often used for soft hydrogel contact lens.…”

Section: Introductionmentioning

confidence: 99%

Antimicrobial Hydrogel Contact Lens Containing Alginate

Lee¹,

Kim²,

Cho

2011

Bulletin of the Korean Chemical Society

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Biocompatible hydrogels from 2-hydroxyethyl methacrylate (HEMA) monomer containing various amount of alginate in the presence and absence of hydrophilic methacrylic acid (MAA) were synthesized in order for biomedical application. The antimicrobial effect and interaction with proteins for hydrogels were investigated in this study. MAA was introduced because it was expected to increase the amount of water content in the polymer which is an important factor for biocompatibility, and alginate was expected to enhance the antimicrobial activity. The antimicrobial effect against S. aureus and E. coli increased for all hydrogels as the amount of alginate and MAA contained. Presence of MAA further enhances the antimicrobial effect. Amount of adsorption of bovine serum albumin (BSA) increased with increasing concentration of alginate whether MAA was present or not. Contrarily, the amount of lysozyme was not affected with increasing alginate concentration in the absence of MAA, while it decreased in the presence of MAA.

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Application of polymer gels containing side‐chain phosphate groups to drug‐delivery contact lenses

Cited by 90 publications

References 49 publications

Recent Advances in Ocular Drug Delivery Systems

Recent Advances in Ocular Drug Delivery Systems

Development and Efficacy of a Drug-Releasing Soft Contact Lens

Antimicrobial Hydrogel Contact Lens Containing Alginate

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