Antimicrobial Hydrogel Contact Lens Containing Alginate

Abstract

Biocompatible hydrogels from 2-hydroxyethyl methacrylate (HEMA) monomer containing various amount of alginate in the presence and absence of hydrophilic methacrylic acid (MAA) were synthesized in order for biomedical application. The antimicrobial effect and interaction with proteins for hydrogels were investigated in this study. MAA was introduced because it was expected to increase the amount of water content in the polymer which is an important factor for biocompatibility, and alginate was expected to enhance the antimicrobial activity. The antimicrobial effect against S. aureus and E. coli increased for all hydrogels as the amount of alginate and MAA contained. Presence of MAA further enhances the antimicrobial effect. Amount of adsorption of bovine serum albumin (BSA) increased with increasing concentration of alginate whether MAA was present or not. Contrarily, the amount of lysozyme was not affected with increasing alginate concentration in the absence of MAA, while it decreased in the presence of MAA.

Applications of ophthalmic biomaterials embedded with fucoidan

“…Therefore, the main factor affecting the extent of protein adsorption may be the interaction between MAA and protein and the protein's size. The recent my study, increasing MAA content in hydrogels with alginate resulted in increased lysozyme adsorption as this result [45]. The water content, which has been reported as a determining factor may not be important.…”

Relationship between the Deposition of Tear Constituents and the Adherence of Candida albicans according to Soft Contact Lens Materials and Pigmentation

“…[2] 특히, 미용 콘택트렌즈의 경우는 착색공법 및 착색제의 종 류에 따라 렌즈 표면의 거칠기 및 표면 특성이 달라지게 된다. [3][4][5][6] 써클 소프트콘택트렌즈(이하 써클렌즈)와 같은 미용 콘 택트렌즈를 비롯한 소프트콘택트렌즈를 10~30대만 착용 하는 것뿐만 아니라 노안교정용 렌즈의 개발로 인하여 40~50대에서의 착용도 증가하고 있다. [7] 또한, 2012년도…”

Antimicrobial materials based on poly(ethylene‐co‐vinyl alcohol) and silver acetate produced by reactive extrusion

“…Several kinds of antimicrobial molecules from different families have been used, such as acids, amino acids, alcohols, terpenes, peptides, proteins, polysaccharides antiseptics, metal oxides, and metal salts . Many additives have been tested to obtain the best antimicrobial activity and to create an optimal material.…”

“…The antimicrobial agent can be introduced during the process directly in the bulk with the raw material or by an immobilization on the package's surface. [6][7][8][9][10][11] Several kinds of antimicrobial molecules from different families have been used, such as acids, [12][13][14][15][16] amino acids, 11,17 alcohols, terpenes, [18][19][20] peptides, proteins, [21][22][23][24] polysaccharides 25,26 antiseptics, [27][28][29][30][31][32][33] metal oxides, and [34][35][36] metal salts. [37][38][39][40][41][42] Many additives have been tested to obtain the best antimicrobial activity and to create an optimal material.…”