Application of poly-ε-caprolactone in extrusion-based bioprinting

Borkar, Tanhai; Goenka, Vidul; Jaiswal, Amit

doi:10.1016/j.bprint.2020.e00111

Cited by 24 publications

(21 citation statements)

References 78 publications

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“…[ 88 ] For skin tissue engineering, PCL can be employed as a scaffold onto which another bioink, such as a cell‐laden hydrogel, can be printed over. [ 88 ] A downside of PCL is that is does not sustain good cell attachment without modification. [ 40 ] This can be overcome by coating the PCL scaffold with an organic polymer.…”

Section: Bioink Typesmentioning

confidence: 99%

“…[87] It has strong mechanical properties, is easily printed, and is biocompatible. [88] It has slow degradation in the body, so it is an oft-used polymer for long-term implants. [88,89] However, its degradability properties can be modified by blending with another polymer, such PLA.…”

Section: Polycaprolactone (Pcl)mentioning

confidence: 99%

“…[88] It has slow degradation in the body, so it is an oft-used polymer for long-term implants. [88,89] However, its degradability properties can be modified by blending with another polymer, such PLA. [88] For skin tissue engineering, PCL can be employed as a scaffold onto which another bioink, such as a cell-laden hydrogel, can be printed over.…”

Section: Polycaprolactone (Pcl)mentioning

confidence: 99%

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3D Bioprinting and Its Role in a Wound Healing Renaissance

Tanfani,

Monpara,

Jonnalagadda

2023

Adv Materials Technologies

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Abstract3D printing (3DP) is an accessible platform being increasingly utilized by independent researchers in fields ranging from industrial manufacturing to medicine. 3D bioprinting is a form of 3D printing that makes use of “bioinks,” organic or synthetic polymer formulations that are often laden with cells. The wide range of materials available means that bioinks can be tailored to the types of tissue that they are meant to emulate. Human skin has a complex microenvironment consisting of numerous layers, cell types, growth factors, and molecular signaling pathways. 3D bioprinting's flexibility and ability to create complex, bioactive structures means that it has great potential in creating artificial skin constructs for skin wound regeneration. While the available materials and cell types for 3DP are large, an ideal bioink for printing artificial skin remains yet to be found. This review will cover the various types of 3DP, the bioinks commonly used, the functionalization of printed artificial skin constructs, challenges that arise in the 3D bioprinting of skin, and future directions for the field. The structure of skin and the wound healing process will also be discussed, as sufficient understanding of these subjects is key to the development of therapeutic artificial skin constructs.

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Section: Bioink Typesmentioning

confidence: 99%

Section: Polycaprolactone (Pcl)mentioning

confidence: 99%

Section: Polycaprolactone (Pcl)mentioning

confidence: 99%

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3D Bioprinting and Its Role in a Wound Healing Renaissance

Tanfani,

Monpara,

Jonnalagadda

2023

Adv Materials Technologies

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“…[14][15][16] Currently, PCL-based tissue engineering scaffolds fabricated by various 3D printing methods, especially fused deposition modeling (FDM) 3D printing, have been reported to replicate structure and function of different biological tissues. [17,18] Nevertheless, the PCL meniscus scaffold-only can lead to severe wear at the surface of the femoral and tibial cartilage due to its high compressive stiffness, which may further exacerbate the progression of OA. [19] To address this problem, soft and elastic hydrogel materials have been widely employed as meniscus substitutes.…”

Section: Introductionmentioning

confidence: 99%

3D Printed High‐Strength Supramolecular Polymer Hydrogel‐Cushioned Radially and Circumferentially Oriented Meniscus Substitute

Zhang

et al. 2022

Adv Funct Materials

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Developing a meniscal replacement with reliable long-term mechanical and functional support has faced a grand challenge due to difficulty in recapitulating the anisotropic microarchitecture and modulus. Herein, a high-strength supramolecular polymer hydrogel-cushioned biomimetic structured meniscus replacement is reported for the first time. The radially and circumferentially oriented poly(e-caprolactone) (PCL) fiber framework is 3D printed to imitate collagen fibers in the native meniscus to provide circumferential tensile supports. Then, hydrogen bonding strengthened anti-swelling poly(N-acryloyl glycinamide) (PNAGA) hydrogel that replicates the function of proteoglycan in resisting axial compressive loads is infused into the 3D printed PCL framework, thus fulfilling a durable energy absorbing and cushion function, which far outperforms the performance of conventional polyacrylamide hydrogel. The PNAGA-cushioned PCL construct can achieve Young's moduli of 20.15 ± 1.37 MPa in the circumferential direction and 10.43 ± 1.54 MPa in the radial direction, a compressive modulus of 1.11 ± 0.14 MPa as well as a tearing energy of 17.00 ± 2.07 kJ m −2 . This 3D printed PCL-PNAGA meniscus scaffold is implanted into rabbit knee joints for 12 weeks and in vivo outcome demonstrates the structural stability and efficient protection against wearing of the cartilage, meanwhile ameliorating the development of osteoarthritis.

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“…Several previous researchers [7,8] have investigated the use of chitosan as an additional material in packaging manufacturing. The use of chitosan in food packaging represents a renewal based on a biodegradable food packaging concept in which the spread of packaging can reduce microorganisms in foods and prevent their development [9]. Chitosan-derived natural food packaging (biofilm) can improve melons' quality and extend their shelf life.…”

Section: Introductionmentioning

confidence: 99%

Biodegradation of Polylactic Acid-Based Bio Composites Reinforced with Chitosan and Essential Oils as Anti-Microbial Material for Food Packaging

Rihayat¹,

Hadi

Aidy

et al. 2021

Polymers

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This study aims to produce and investigate the potential of biodegradable Polylactic Acid (PLA)-based composites mixed with chitosan and Turmeric Essential Oil (TEO) as an anti-microbial biomaterial. PLA has good barrier properties for moisture, so it is suitable for use as a raw material for making packaging and is included in the GRAS (Generally Recognized As Safe). Chitosan is a non-toxic and antibacterial cationic polysaccharide that needs to be improved in its ability to fight microbes. TEO must be added to increase antibacterial properties due to a large number of hydroxyl (-OH) and carbonyl functional groups. The samples were prepared in three different variations: 2 g of chitosan, 0 mL TEO and 0 mL glycerol (Biofilm 1), 3 g of chitosan, 0.3 mL TEO and 0.5 mL of glycerol (Biofilm 2), and 4 g of chitosan, 0.3 of TEO and 0.5 mL of glycerol (Biofilm 3). The final product was characterized by its functional group through Fourier transform infrared (FTIR); the functional groups contained by the addition of TEO are C-H, C=O, O-H, and N-H with the extraction method, and as indicated by the emergence of a wide band at 3503 cm−1, turmeric essential oil interacts with the polymer matrix by creating intermolecular hydrogen bonds between their terminal hydroxyl group and the carbonyl groups of the ester moieties of both PLA and Chitosan. Thermogravimetric analysis (TGA) of PLA as biofilms, the maximum temperature of a biofilm was observed at 315.74 °C in the variation of 4 g chitosan, 0.3 mL TEO, and 0.5 mL glycerol (Biofilm 3). Morphological conditions analyzed under scanning electron microscopy (SEM) showed that the addition of TEO inside the chitosan interlayer bound chitosan molecules to produce solid particles. Chitosan and TEO showed increased anti-bacterial activity in the anti-microbial test. Furthermore, after 12 days of exposure to open areas, the biofilms generated were able to resist S. aureus and E. coli bacteria.

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Application of poly-ε-caprolactone in extrusion-based bioprinting

Cited by 24 publications

References 78 publications

3D Bioprinting and Its Role in a Wound Healing Renaissance

3D Bioprinting and Its Role in a Wound Healing Renaissance

3D Printed High‐Strength Supramolecular Polymer Hydrogel‐Cushioned Radially and Circumferentially Oriented Meniscus Substitute

Biodegradation of Polylactic Acid-Based Bio Composites Reinforced with Chitosan and Essential Oils as Anti-Microbial Material for Food Packaging

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