Application of Platelet Rich Plasma in Sports Medicine

Ficek, Krzysztof; Kamiński, Tomasz; Wach, Ewa; Cholewiński, Jerzy

doi:10.2478/v10078-011-0076-z

Cited by 21 publications

(11 citation statements)

References 46 publications

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“…The growth factors released by PRP have been discussed in great detail within the literature (Lubkowska et al 2012;Pavlovic et al 2016;Fernandes and Yang 2016;Parrish and Roides 2018) and have been shown to promote cell recruitment, proliferation and angiogenesis resulting in a reduction in the critical regulators of the inflammatory process and a decrease in the expression of inflammatory enzymes (Table 2) (van Buul et al 2011). PRP may induce a regenerative response by improving the metabolic functions of damaged structures (Ficek et al 2011;Chen et al 2018) and has been shown to have a positive effect on chondrogenesis and mesenchymal stem cell proliferation (Kabiri et al 2014).…”

Section: Current Knee Osteoarthritis Incidence and Management Strategiesmentioning

confidence: 99%

The use of PRP injections in the management of knee osteoarthritis

2019

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Osteoarthritis (OA) is a degenerative disease involving joint damage, an inadequate healing response and progressive deterioration of the joint architecture that commonly affects the knee and/or hip joints. It is a major world public health problem and is predicted to increase rapidly with an ageing population and escalating rate of obesity. Autologous blood-derived products possess much promise in the repair and regeneration of tissue and have important roles in inflammation, angiogenesis, cell migration and metabolism in pathological conditions, including OA. Utilising platelet-rich plasma (PRP) to treat tendon, ligament and skeletal muscle has shown variable results across many studies with the current evidence base for the efficacy of PRP in treating sports injuries remaining inconclusive. More uniformly positive results have been observed by various studies for PRP in OA knee in comparison to hyaluronic acid, other intra-articular injections and placebo than in other musculoskeletal tissue. However, methodological concerns as well as satisfactory PRP product classification prevent the true characterisation of this treatment. Thus, further research is required to investigate how leukocyte inclusion, activation and platelet concentration affect therapeutic efficacy. Furthermore, the optimisation of timing, dosage, volume, frequency and rehabilitation strategies need to be ascertained. For knee OA management, these concerns must be addressed before this promising treatment can be widely implemented.

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Section: Current Knee Osteoarthritis Incidence and Management Strategiesmentioning

confidence: 99%

The use of PRP injections in the management of knee osteoarthritis

2019

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“…Platelet‐rich plasma contains a high concentration of growth factors that promote proliferation, migration, cell differentiation, and angiogenesis 31 . Platelet‐rich plasma has been used widely in sports medicine, dental medicine, wound repair, and alopecia with growing evidence of its efficacy in recent 30 years 31,32 . Because plantar fasciitis represents a chronic, degenerative process, theoretically platelet‐rich plasma could be beneficial for tissue repair and regeneration in the plantar fascia.…”

Section: Discussionmentioning

confidence: 99%

“…31 Platelet-rich plasma has been used widely in sports medicine, dental medicine, wound repair, and alopecia with growing evidence of its efficacy in recent 30 years. 31,32 Because plantar fasciitis represents a chronic, degenerative process, theoretically platelet-rich plasma could be beneficial for tissue repair and regeneration in the plantar fascia. However, there was no standardized method in preparing platelet-rich plasma across these studies, and there is no consensus regarding the best concentration or volume for injection in plantar fasciitis or other musculoskeletal conditions.…”

Section: Discussionmentioning

confidence: 99%

The Comparative Effectiveness of Autologous Blood‐derived Products Versus Steroid Injections in Plantar Fasciitis: A Systematic Review and Meta‐analysis of Randomized Controlled Trials

Tseng

Chiu

et al. 2020

PM&R

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Objective Plantar fasciitis is one of the most common musculoskeletal diseases, and nearly 90% of patients can be successfully treated by nonsurgical options. However, it is yet to be determined which nonsurgical treatment has the best efficacy. The present study investigated differences between autologous blood‐derived products and corticosteroid injections in the treatment of plantar fasciitis. Type Systematic Review and Meta‐analysis. Literature Survey PubMed, EMBASE, CINAHL, and Web of Science were searched for relevant articles up to November 2019. There was no language restriction, and unpublished trials were excluded. This systematic review included only randomized controlled trials. Methodology The primary outcomes were Visual Analog Scale and American Orthopedic Foot and Ankle Score (AOFAS). The follow‐up times were divided into short term (3‐6 weeks), intermediate term (3 months or 12 weeks), and long term (6 months or 24 weeks). The random‐effects model was utilized, and weighted mean difference was calculated as the pool estimates. Synthesis Thirteen randomized controlled trials and 640 patients were included. No significant difference in Visual Analog Scale reduction was observed between autologous blood‐derived product and corticosteroid injections in the short term (weighted mean difference [WMD] = −0.84; 95% confidence interval [CI], −1.71 to 0.03; P = .057), intermediate term (WMD = −0.24; 95% CI, −0.90 to 0.42; P = .475), and long term (WMD = 0.47; 95% CI, −0.72 to 1.65; P = .44). No significant difference in AOFAS was observed between autologous blood‐derived products and corticosteroids in the short term (WMD = −0.65; 95% CI, −5.40 to 4.10; P = .79), intermediate term (WMD = 0.17; 95% CI, −8.07 to 8.41; P = .97), and long term (WMD = 1.16; 95% CI, −4.54 to 6.86; P = .69). Conclusions This systematic review and meta‐analysis of autologous blood‐derived products versus corticosteroids for plantar fasciitis is the first that includes only randomized controlled trials. The meta‐analysis found no significant difference between autologous blood‐derived products and corticosteroids, as measured by Visual Analog Scale or AOFAS. These findings applied whether followed up in short, intermediate, or long term. These results differ from previous studies that showed superior efficacy of autologous blood‐derived products compared with corticosteroids in the long term.

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“…PRP/PRF used along with collagen membranes was extensively applied for regeneration of periodontal ligament and alveolar bone as a part of guided tissue regeneration procedures in periodontics and oral surgery. PRP therapy was shown to be a successful promoter in the healing process (Ficek, Kaminski, Wach, Cholewinski, & Cieszczyk, 2011; Khodakaram-Tafti, Mehrabani, & Shaterzadeh-Yazdi, 2017). PRP and its associated formulations have yet to show promise in dental pulp regeneration, though.…”

Section: Biomaterials-based Scaffolds For Regenerating the Dentin-pulmentioning

confidence: 99%

Present and future of tissue engineering scaffolds for dentin‐pulp complex regeneration

Moussa

Aparicio

2018

J Tissue Eng Regen Med

126

140

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More than two thirds of the global population suffers from tooth decay, which results in cavities with various levels of lesion severity. Clinical interventions to treat tooth decay range from simple coronal fillings to invasive root canal treatment. Pulp capping is the only available clinical option to maintain the pulp vitality in deep lesions, but irreversible pulp inflammation and reinfection are frequent outcomes for this treatment. When affected pulp involvement is beyond repair, the dentist has to perform endodontic therapy leaving the tooth non-vital and brittle. On-going research strategies have failed to overcome the limitations of existing pulp capping materials so that healthy and progressive regeneration of the injured tissues is attained. Preserving pulp vitality is crucial for tooth homeostasis and durability, and thus, there is a critical need for clinical interventions that enable regeneration of the dentin-pulp complex to rescue millions of teeth annually. The identification and development of appropriate biomaterials for dentin-pulp scaffolds are necessary to optimize clinical approaches to regenerate these hybrid dental tissues. Likewise, a deep understanding of the interactions between the micro-environment, growth factors, and progenitor cells will provide design basis for the most fitting scaffolds for this purpose. In this review, we first introduce the long-lasting clinical dental problem of rescuing diseased tooth vitality, the limitations of current clinical therapies and interventions to restore the damaged tissues, and the need for new strategies to fully revitalize the tooth. Then, we comprehensively report on the characteristics of the main materials of naturally-derived and synthetically-engineered polymers, ceramics, and composite scaffolds as well as their use in dentin-pulp complex regeneration strategies. Finally, we present a series of innovative smart polymeric biomaterials with potential to overcome dentin-pulp complex regeneration challenges.

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Application of Platelet Rich Plasma in Sports Medicine

Cited by 21 publications

References 46 publications

The use of PRP injections in the management of knee osteoarthritis

The use of PRP injections in the management of knee osteoarthritis

The Comparative Effectiveness of Autologous Blood‐derived Products Versus Steroid Injections in Plantar Fasciitis: A Systematic Review and Meta‐analysis of Randomized Controlled Trials

Present and future of tissue engineering scaffolds for dentin‐pulp complex regeneration

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