Objective Plantar fasciitis is one of the most common musculoskeletal diseases, and nearly 90% of patients can be successfully treated by nonsurgical options. However, it is yet to be determined which nonsurgical treatment has the best efficacy. The present study investigated differences between autologous blood‐derived products and corticosteroid injections in the treatment of plantar fasciitis. Type Systematic Review and Meta‐analysis. Literature Survey PubMed, EMBASE, CINAHL, and Web of Science were searched for relevant articles up to November 2019. There was no language restriction, and unpublished trials were excluded. This systematic review included only randomized controlled trials. Methodology The primary outcomes were Visual Analog Scale and American Orthopedic Foot and Ankle Score (AOFAS). The follow‐up times were divided into short term (3‐6 weeks), intermediate term (3 months or 12 weeks), and long term (6 months or 24 weeks). The random‐effects model was utilized, and weighted mean difference was calculated as the pool estimates. Synthesis Thirteen randomized controlled trials and 640 patients were included. No significant difference in Visual Analog Scale reduction was observed between autologous blood‐derived product and corticosteroid injections in the short term (weighted mean difference [WMD] = −0.84; 95% confidence interval [CI], −1.71 to 0.03; P = .057), intermediate term (WMD = −0.24; 95% CI, −0.90 to 0.42; P = .475), and long term (WMD = 0.47; 95% CI, −0.72 to 1.65; P = .44). No significant difference in AOFAS was observed between autologous blood‐derived products and corticosteroids in the short term (WMD = −0.65; 95% CI, −5.40 to 4.10; P = .79), intermediate term (WMD = 0.17; 95% CI, −8.07 to 8.41; P = .97), and long term (WMD = 1.16; 95% CI, −4.54 to 6.86; P = .69). Conclusions This systematic review and meta‐analysis of autologous blood‐derived products versus corticosteroids for plantar fasciitis is the first that includes only randomized controlled trials. The meta‐analysis found no significant difference between autologous blood‐derived products and corticosteroids, as measured by Visual Analog Scale or AOFAS. These findings applied whether followed up in short, intermediate, or long term. These results differ from previous studies that showed superior efficacy of autologous blood‐derived products compared with corticosteroids in the long term.
A 33-year-old woman with cryoglobulinaemia developed acute hydrocephalus 20 h after lumbar myelography using the water-soluble contrast medium iotrolan. After a ventricular drainage, she was free of symptoms and the hydrocephalus resolved. The development of acute hydrocephalus after myelography has not been reported previously.
Suicide is a major threat to adolescent health. Sleep problems increase the risk of adolescent suicidal behavior, but the role of sleep-disordered breathing (e.g., sleep apnea) is unclear. We investigated whether sleep apnea had an effect on suicidal ideation that was independent of depression and perceived stress. We examined a series of sleep variables with suicidal ideation in 746 fifth and seventh graders using self-reported questionnaires to assess time in bed, sleep quality, insomnia, and sleep apnea while controlling depression and perceived stress. Overall, 8.8% of students aged 10-14 years reported having recent suicidal ideation, and 33% or 3.8%, depending on the screening criteria, reported having suspected sleep apnea. The sleep variables were all associated with an increased risk of suicidal ideation, but the magnitude of effects was largely attenuated when depression and perceived stress were included in the models. Suspected sleep apnea using daytime sleepiness as a screening criterion was independently associated with suicidal ideation (odds ratio = 2.25, p < 0.05). Suspected sleep apnea was associated with suicidal ideation that was partly independent of depression and stress, which reveals the pertinence of screening for sleep apnea among school students and designing proper prevention strategies for reducing youth suicidal behavior.
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