Application of Platelet-Rich Fibrin and Injectable Platelet-Rich Fibrin in Combination of Bone Substitute Material for Alveolar Ridge Augmentation - a Case Report

Abstract

Background:Different barrier membranes and augmentation techniques are used in oral surgery to recover lost bone structures with varied success. Recently, a combination between bone graft materials and Platelet-Rich-Fibrin (PRF) is implemented in the periodontology and implantology.Aim: The aim of this case report was to assess the possibility for augmentation of the alveolar ridge in the frontal region of the upper jaw, utilizing a combination of bone graft material, injectable platelet-rich-fibrin (i-PRF) and advanced platelet-rich fibrin (A-PRF).Materials and methods:An 18 year-old male with expulsion of tooth 11 and partial fracture of the alveolar ridge was treated with augmentation of the alveolar ridge using bone graft material, injectable platelet–rich-fibrin(i-PRF) and advanced platelet-rich-fibrin (A-PRF). Clinical results were reviewed 4 months after the augmentation and a dental implant was placed.Results:The postoperative period was uneventful. The control CBCT scan showed good organization of new bone allowing placement of a dental implant.Conclusion:The successful clinical and radiographic results of the case suggest that using A-PRF and i-PRF can be beneficial for bone augmentation of the alveolar ridge before implant placement.

Systematic Comparison of the Effect of Four Clinical-Grade Platelet Rich Hemoderivatives on Osteoblast Behaviour

“…Similar results were reported previously [41], showing the superior mineralisation potential of i-PRF over L-PRP. The in-vitro results could explain the positive bone regeneration outcomes when i-PRF is utilised as a supplement [8,11]. However, this finding is not entirely consistent with the biochemical composition measured in the i-PRF exudate (after three days of incubation).…”

“…The results reported in the literature are contradictory and the subsequent regeneration efficacy of these blood products remains debatable, especially in the context of bone formation [14,15]. Indeed, platelet rich fibrin products are osteoinductive (the capacity to induce ectopic bone formation) [33], but the bone regeneration properties of these hemoderivatives in combination with particulate bone substitutes have shown divergent outcomes [10,11,15,34]. This could be attributed to variations in the implantation sites or is also likely to be due to differences in the blood product manufacturing methods.…”

“…Growth factors, such as insulin-like growth factor-1 (IGF-I), platelet-derived growth factor (PDGF), vascular endothelial growth factor (VEGF), fibroblast growth factor (FGF), epidermal growth factor (EGF), platelet-derived epidermal growth factor (PDEGF) and fibrin matrix proteins, are found in these preparations at a higher concentration than in blood, and have been proposed to directly contribute to accelerating tissue regeneration [5][6][7]. Hemoderivative preparations have also been frequently used as a surgical adjuvant to improve healing and promote tissue regeneration in the treatment of intrabony defects [8][9][10], alveolar ridge augmentation [11], post-extraction socket preservation [12], treatment of membrane perforation [13] and maxillary sinus augmentation [14,15].…”

Leucocyte‐ and platelet‐rich fibrin block for bone augmentation procedure: A proof‐of‐concept study

“…i‐PRF has been tested with different centrifugation speeds to selectively enrich leucocytes, platelets and growth factors release (Choukroun & Ghanaati, ). Recently, a case report described a similar technique using i‐PRF (Chenchev, Ivanova, Neychev, & Cholakova, ). However, a specific clinical protocol, with radiological results, is still missing.…”

Guided bone regeneration in staged vertical and horizontal bone augmentation using platelet-rich fibrin associated with bone grafts: a retrospective clinical study

“…L-PRF is related to improved soft tissue regeneration once it contains several growth factors such as platelet-derived growth factor (PDGF), transforming growth factor beta (TGF-β), vascular endothelial growth factor (VEGF), and insulin-like growth factor (IGF) [17]. Thus, their use is indicated to improve soft-tissue healing and reduce tissue dehiscence [35], reduce postoperative pain and swelling, and minimize infection in the surgical area [36]. This aspect can also be described in the present study, once no case included in this study presented post-surgery complication or membrane exposure.…”