Application of Ortho Esterification under Kinetically Controlled Conditions to the Selective Acylation in the D-Gluco-, D-Ribo- and D-Xylo-furanose Series

Small BODIPY Probes for Combined Dual 19F MRI and Fluorescence Imaging

“…[3] Therefore, it is highly desirable to establish more abundanti ons as alternatives, such as iron (Fe 3 + ) [4] or manganese (Mn 2 + ), [5] which might overcomet hese toxic effects. Another way may be to switch the nucleus from 1 Ht o 19 FMRI.T he 19 Fn ucleus is also well suited for MRI, given its natural abundance of 100 %, high gyromagnetic ratio, spin of 1 = 2 and high receptivity of 0.834 relative to 1 H. Additionally,t here is no 19 FMRI background in biological systems. Hence, in the last few years numerous papers about 19 FMRI have been published.…”

“…Another way may be to switch the nucleus from 1 Ht o 19 FMRI.T he 19 Fn ucleus is also well suited for MRI, given its natural abundance of 100 %, high gyromagnetic ratio, spin of 1 = 2 and high receptivity of 0.834 relative to 1 H. Additionally,t here is no 19 FMRI background in biological systems. Hence, in the last few years numerous papers about 19 FMRI have been published.…”

“…Currently,m ost of the 19 FMRI agentso rt racers are perfluorocarbone mulsions (PFC), which contain ah igh number of covalentlyb ound 19 Fa toms and are easily modified for further applications. [6] Unfortunately,P FCs have shown several disadvantages such as heterogeneity,i nstability,m ultiple 19 Fs ignals, difficult synthesis, and also accumulationo re ven retention within organs for ac ouple of months. [6c, 7] These drawbacks are largely overcome in as econd group of 19 FMRI tracers based on small molecules.…”

“…[6] Unfortunately,P FCs have shown several disadvantages such as heterogeneity,i nstability,m ultiple 19 Fs ignals, difficult synthesis, and also accumulationo re ven retention within organs for ac ouple of months. [6c, 7] These drawbacks are largely overcome in as econd group of 19 FMRI tracers based on small molecules. [8] The as-yet-described molecules are chemically stable, easy to synthesize, and have shown short The combination of the two complementary imaging modalities 19 Fm agnetic resonance imaging (MRI) and fluorescence imaging (FLI) possesses high potential for biological and medical applications.H erein we report the first design, synthesis, dual detection validation, and cytotoxic testing of four promising BODIPY dyes for dual 19 FMRI-fluorescence detection.…”

“…[6c, 7] These drawbacks are largely overcome in as econd group of 19 FMRI tracers based on small molecules. [8] The as-yet-described molecules are chemically stable, easy to synthesize, and have shown short The combination of the two complementary imaging modalities 19 Fm agnetic resonance imaging (MRI) and fluorescence imaging (FLI) possesses high potential for biological and medical applications.H erein we report the first design, synthesis, dual detection validation, and cytotoxic testing of four promising BODIPY dyes for dual 19 FMRI-fluorescence detection. Using straightforward Steglich reactions, smallf luorinated alcohols were easily covalently tethered to aB ODIPY dye in high yields, leaving its fluorescence properties unaffected.…”