Application of organic frame materials in cancer therapy through regulation of tumor microenvironment

Yao, Shuncheng; Wang, Zhuo; Li, Linlin

doi:10.1016/j.smaim.2022.01.006

Cited by 31 publications

(15 citation statements)

References 124 publications

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“…The buildup of oxygen radicals causes oxidative stress, which enhances inflammation in a variety of illnesses, including chronic inflammatory diseases and neoplasms (Meng et al, 2021; Reuter, Gupta, Chaturvedi, & Aggarwal, 2010). Also, diabetes, cardiovascular disease, and neurodegenerative diseases are all manifestations of chronic oxidative stress (Ma, Zhang, Chen, & Wang, 2021; Yao, Wang, & Li, 2022; Zhao et al, 2022).…”

Section: Introductionmentioning

confidence: 99%

“…The mechanisms of generation of free radicals happen generally within the mitochondria, cytoplasm, and cell membranes. Reactive oxygen species (ROS) and reactive nitrogen species (RNS) are shaped as unavoidable by‐products of metabolism (Ma et al, 2021; Yao et al, 2022; Zhao et al, 2022). The installation prepare of oxidative stress emerges from an imbalance between oxidants and antioxidants in favor of excessive generation of free radicals or elimination speed thereof.…”

Section: Introductionmentioning

confidence: 99%

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Resveratrol regulates inflammation and improves oxidative stress via Nrf2 signaling pathway: Therapeutic and biotechnological prospects

Shahcheraghi

Salemi

Small

et al. 2023

Phytotherapy Research

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Usually, in aerobic metabolism, natural materials including nucleic acids, proteins, and lipids can experience auxiliary injury by oxidative responses. This damage produced by reactive oxygen/nitrogen species has been identified as “oxidative stress.” As a natural polyphenol got from red wine and peanuts, resveratrol is one of the most eminent anti‐aging mixtures. Based on many studies', resveratrol hinders destructive effects of inflammatory causes and reactive oxygen radicals in several tissues. The nuclear erythroid 2‐related factor 2 is a factor related to transcription with anti‐inflammatory, antioxidant possessions which is complicated by enzyme biotransformation and biosynthesis of lipids and carbohydrates. This review provides current understanding and information about the character of resveratrol against oxidative stress and regulation of inflammation via Nrf2 signaling pathway.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Resveratrol regulates inflammation and improves oxidative stress via Nrf2 signaling pathway: Therapeutic and biotechnological prospects

Shahcheraghi

Salemi

Small

et al. 2023

Phytotherapy Research

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“…There are still obstacles associated with the high glutathione (GSH) content in tumour tissues that depletes 1 O 2 and reduces the PDT efficiency. GSH is the most abundant antioxidant in human bodies, which can eliminate ROS and protect cells from acute toxicity, as well as repair damaged biomolecules [ 98 ]. The GSH concentration in cancer cells is often higher than that in normal cells making it one of the main obstacles for ROS-induced cell killing.…”

Section: Porphyrin Mofs As Theranostic Agentsmentioning

confidence: 99%

Porphyrin NanoMetal-Organic Frameworks as Cancer Theranostic Agents

2022

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Metal-Organic Frameworks (MOFs) are hybrid multifunctional platforms that have found remarkable applications in cancer treatment and diagnostics. Independently, these materials can be employed in cancer treatment as intelligent drug carriers in chemotherapy, photothermal therapy, and photodynamic therapy; conversely, MOFs can further be used as diagnostic tools in fluorescence imaging, magnetic resonance imaging, computed tomography imaging, and photoacoustic imaging. One essential property of these materials is their great ability to fine-tune their composition toward a specific application by way of a judicious choice of the starting building materials (metal nodes and organic ligands). Moreover, many advancements were made concerning the preparation of these materials, including the ability to downsize the crystallites yielding nanoporous porphyrin MOFs (NMOFs) which are of great interest for clinical treatment and diagnostic theranostic tools. The usage of porphyrins as ligands allows a high degree of multifunctionality. Historically these molecules are well known for their reactive oxygen species formation and strong fluorescence characteristics, and both have proved helpful in cancer treatment and diagnostic tools. The anticipation that porphyrins in MOFs could prompt the resulting materials to multifunctional theranostic platforms is a reality nowadays with a series of remarkable and ground-breaking reports available in the literature. This is particularly remarkable in the last five years, when the scientific community witnessed rapid development in porphyrin MOFs theranostic agents through the development of imaging technologies and treatment strategies for cancer. This manuscript reviews the most relevant recent results and achievements in this particular area of interest in MOF chemistry and application.

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“…Reactive oxygen species (ROS) are a group of highly active oxygen-containing molecules generated from molecular oxygen (O 2 ) during the electron transfer process, mainly including superoxide anion (•O 2 − ), [1] hydrogen peroxide (H 2 O 2 ), [2] hydroxyl radical (•OH), [3] and singlet oxygen ( 1 O 2 ). [4] In organisms, ROS are generally produced in the mitochondrial electron transport chain and can participate in the regulation of cell signaling pathways to maintain cellular metabolic balance. [5,6] It has been proved that excess ROS, especially oxygen free radicals, can lead to cellular oxidative stress and oxidative damage, which may induce a variety of diseases, [7,8] such as cancer, immune diseases, and neurodegenerative diseases.…”

Section: Introductionmentioning

confidence: 99%

Piezotronic and piezo‐phototronic effects on sonodynamic disease therapy

Zhao

Huang

Zhang

et al. 2023

BMEMat

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With the development of engineered nanomaterials and nanomedicines, utilization of nanomaterials to generate excessive reactive oxygen species under exogenous ultrasound (US) irradiation for realizing disease therapy, namely sonodynamic therapy (SDT), has attracted widespread attention. Compared with traditional photodynamic therapy, US shows deeper tissue penetration to reach deep-seated location. However, the development of high-efficiency sonosensitizers remains one of the gravest challenges in current related research and future clinical application. Latterly, benefiting from the piezotronic and piezo-phototronic effects, novel sonosensitizers based on piezoelectric semiconductor (PS) nanomaterials have exhibited inspiring application prospects in SDT. In this review, we outline the structures and physicochemical properties of PS nanomaterials that has potential applications in SDT, and introduce the presumed mechanisms of PS nanomaterials in SDT. Then, the latest research progress of PS nanomaterials as sonosensitizers in cancer therapy and antibacterial applications are summarized. Finally, the existing challenges and future development trends in this field are prospected.

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Application of organic frame materials in cancer therapy through regulation of tumor microenvironment

Cited by 31 publications

References 124 publications

Resveratrol regulates inflammation and improves oxidative stress via Nrf2 signaling pathway: Therapeutic and biotechnological prospects

Resveratrol regulates inflammation and improves oxidative stress via Nrf2 signaling pathway: Therapeutic and biotechnological prospects

Porphyrin NanoMetal-Organic Frameworks as Cancer Theranostic Agents

Piezotronic and piezo‐phototronic effects on sonodynamic disease therapy

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