Application of New Radiosensitizer Based on Nano-Biotechnology in the Treatment of Glioma

Abstract

Glioma is the most common intracranial malignant tumor, and its specific pathogenesis has been unclear, which has always been an unresolved clinical problem due to the limited therapeutic window of glioma. As we all know, surgical resection, chemotherapy, and radiotherapy are the main treatment methods for glioma. With the development of clinical trials and traditional treatment techniques, radiotherapy for glioma has increasingly exposed defects in the treatment effect. In order to improve the bottleneck of radiotherapy for glioma, people have done a lot of work; among this, nano-radiosensitizers have offered a novel and potential treatment method. Compared with conventional radiotherapy, nanotechnology can overcome the blood–brain barrier and improve the sensitivity of glioma to radiotherapy. This paper focuses on the research progress of nano-radiosensitizers in radiotherapy for glioma.

The Mössbauer effect using 57Fe-ferrabisdicarbollide ([o-57FESAN]−): a glance into the potential of a low-dose approach for glioblastoma radiotherapy

“…However, these conventional radiotherapy sensitizers can cause many adverse side effects and acquired resistance. 16…”

“…However, these conventional radiotherapy sensitizers can cause many adverse side effects and acquired resistance. 16 Recent studies have demonstrated that 3D hybrid organicinorganic compounds, known as carboranes, can have a role in the development of novel small molecules for the treatment of various types of cancer. [17][18][19][20][21] The synthetic flexibility of carboranes, along with their rigid structure and chemical stability, makes them appealing moieties for their use in cancer drug development.…”

Combining Nanocarrier-Assisted Delivery of Molecules and Radiotherapy

“…A range of compounds that influence, for example, DNA repair (especially doublestrand break repair), act as radiosensitizers by increasing damage to the irradiated cells, leading to increased cell death [30]. However, these compounds present side effects that sometimes hamper their use [31]. Effective radiosensitizers should have less effect on normal tissues [21].…”

Multifunctional lipidic nanocarriers for effective therapy of glioblastoma: recent advances in stimuli-responsive, receptor and subcellular targeted approaches

“…Researchers have put in a lot of effort to improve the limitations in glioma radiotherapy, and nano-radiosensitizers have emerged as a promising treatment choice. Using nanotechnology to develop novel nano-sized platforms that cross the BBB and deliver a high concentration of the drugs into the tumor, thereby increasing tumor response to radiotherapy, is fast becoming an attractive approach to improve radiotherapy outcomes in these tumors (Liu et al 2017a;Xie et al 2021).…”