Application of Nanoparticles in Quartz Crystal Microbalance Biosensors

Abstract

Nanoparticles are playing an increasingly important role in the development of biosensors. The sensitivity and performance of biosensors are being improved by using Nanoparticles for their construction. The use of these Nanoparticles has allowed the introduction of many new signal transduction technologies in biosensors. In this report, a comprehensive review of application of nanoparticles in Quartz Crystal Microbalance biosensors is presented. The main advantages of QCM in sensing fields include high sensitivity, high stability, fast response and low cost. In addition, it provides label-free detection capability for bio-sensing applications. Firstly, basic QCM's design and characterization are described. Next, QCM biosensors based on modification of quartz substrate structure and their applications are digested. Nanoparticles and their utilizationin analysis are then illustrated. These include Nanoparticles in bio applications that cover Nanoparticles in Quartz Crystal Microbalance biosensors.

Recent trends in the detection of pathogenic Escherichia coli O157 : H7

“…A novel antibody-conjugated gold nanoparticle composite developed by Guo et al increased the sensitivity of the QCM to pathogen by more than order of magnitude 67 Over the past ten years gold nanoparticles in combination with QCM devices have led to significant improvements in the LOD of E. coli O157 : H7. A broader review of OCM biosensors and the signal enhancing properties of noble nanoparticles can be found in a recent paper by Heydari et al 71 .…”

Noble metal nanoparticles in biosensors: recent studies and applications

“…The quartz crystal microbalance (QCM) is the most popular piezoelectric detector and works based on sending an electrical signal through a gold-plated quartz crystal with a biorecognition element on its surface. When binding occurs, the mass change produces vibrations in the crystal, and the frequency of oscillation in the crystal changes [209]. MNPs have been studied for their ability to amplify signals and enhance sensitivity in several types of piezoelectric biosensors.…”

Quartz crystal microbalance gas sensor with nanocrystalline diamond sensitive layer

“…The quartz crystal microbalance (QCM) represents a highly sensitive sensor for a detection of chemical and biological substances or to study nanoparticle self‐assembly processes, nanocomposite materials, and track nanoparticle interactions in the environment . QCM‐based sensors are widely utilized as a results of their robust nature, availability, affordable interface electronics, and usability in liquid and gaseous environments .…”