Application of Nano-Drug Delivery System Based on Cascade Technology in Cancer Treatment

Abstract

In the current cancer treatment, various combination therapies have been widely used, such as photodynamic therapy (PDT) combined with chemokinetic therapy (CDT). However, due to the complexity of the tumor microenvironment (TME) and the limitations of treatment, the efficacy of current treatment options for some cancers is unsatisfactory. Nowadays, cascade technology has been used in cancer treatment and achieved good therapeutic effect. Cascade technology based on nanotechnology can trigger cascade reactions under specific tumor conditions to achieve precise positioning and controlled release, or amplify the efficacy of each drug to improve anticancer efficacy and reduce side effects. Compared with the traditional treatment, the application of cascade technology has achieved the controllability, specificity, and effectiveness of cancer treatment. This paper reviews the application of cascade technology in drug delivery, targeting, and release via nano-drug delivery systems in recent years, and introduces their application in reactive oxygen species (ROS)-induced cancer treatment. Finally, we briefly describe the current challenges and prospects of cascade technology in cancer treatment in the future.

The Influence of Cell Cycle Regulation on Chemotherapy

“…TAX is a member of the taxane family and exerts an anti-tumor effect by targeting microtubules in cancer cells. Studies have shown that TAX has anti-angiogenic effects and induces tumor cell apoptosis [77]. Dihydroartemisinin (DHA), as an anti-angiogenic drug, inhibits the expression of fatty acid synthase (FASN) and inhibits endothelial cell (EC) tube production by inhibiting the STAT3 signaling pathway [78].…”

Combining nanotechnology with the multifunctional roles of neutrophils against cancer and inflammatory disease

“…However, the application of nanotherapeutics also faces several challenges like immunogenicity, poor biocompatibility and short circulation time. 9,10 Thus, there are numerous advantages of integrating neutrophils with emerging nanomaterials in one platform, such as inheriting the innate properties of neutrophils to elevate the targetability and biocompatibility of the constructed DDS, utilizing the multifunctionality of nanomaterials to empower the therapeutic area of a neutrophil-based drug delivery system (NDDS), and enabling various therapeutic modalities in biomimetic platforms for improved efficacy and reduced toxicity (Fig. 1).…”

Marine Polysaccharides as a Versatile Biomass for the Construction of Nano Drug Delivery Systems

“…At present, nanocarriers have been widely used to deliver drugs [ 5 ], peptides [ 6 ], and nucleic acids [ 7 ]. Nanocarriers can (1) help drugs avoid rapid clearance during circulation and prolong their time in the blood [ 8 ], (2) be enriched at the lesion site through enhanced permeability and retention effect (EPR effect) or active targeting, which improves the utilization of drugs and reduces toxic and side effects [ 9 ], and (3) realize the controlled release of drugs through internal (e.g., pH) or external (e.g., radiation) stimulation signals [ 10 ]. Some DDSs have realized the transformation from laboratory to clinical [ 11 ].…”