Application of multivariate optimization to electrochemical determination of methyldopa drug in the presence of diclofenac at a nanostructured electrochemical sensor

Ghoreishi, Sayed Mehdi; Saeidinejad, Faezeh; Behpour, Mohsen; Masoum, Saeed

doi:10.1016/j.snb.2015.06.129

Cited by 13 publications

(4 citation statements)

References 50 publications

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“…Table 1 shows a comparison of the CPE/AuNP/DAS-DMSO with other modified electrodes for methyldopa determination, based on data published in the literature [33][34][35][36][37][38][39]. The LOD value obtained in this study is in agreement with others reported in the literature, indicating that the proposed methodology is suitable for the determination of methyldopa.…”

Section: Calibration Curvesupporting

confidence: 85%

Sensor Modified with Gold Nanoparticles Stabilized in Dialdehyde Starch/DMSO Matrix for Methyldopa Detection

Freitas

Vieira

2022

Electroanalysis

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In this study, gold nanoparticles (AuNP) were synthesized using a novel stabilizer based on dialdehyde starch polymer (DAS) and dimethyl sulfoxide (DMSO) and the nanomaterial was applied to develop a sensor for methyldopa detection. The nanoparticles were characterized by transmission electron microscopy and the proposed sensor was electrochemically characterized by electrochemical impedance spectroscopy, chronocoulometry and square-wave voltammetry. Under optimized conditions (0.1 mol L À 1 McIlvaine buffer solution at pH 3.5 and 50 μL AuNP/DAS-DMSO), using square-wave voltammetry, the calibration curve presented a linear range of 0.99 to 19.60 μmol L À 1 , with a detection limit of 0.50 μmol L À 1 . The sensor showed good accuracy, with coefficients of variation of 7.8 % (inter-day; n = 6) and 5.9 % (intra-day; n = 3), and recovery values in the range of 95.3 to 105.2 %. The methyldopa content in a pharmaceutical sample was determined and the results show good correlation with the label value and the method recommended by the Pharmacopoeia, representing a fast and accurate alternative for detecting methyldopa in pharmaceutical products.

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Section: Calibration Curvesupporting

confidence: 85%

Sensor Modified with Gold Nanoparticles Stabilized in Dialdehyde Starch/DMSO Matrix for Methyldopa Detection

Freitas

Vieira

2022

Electroanalysis

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“…Experimental design has been frequently used in the statistical optimization of analytical approaches because of its advantages such as reduction in the number of experiments that leads to the considerably less laboratory work and lower reagent consumption, as well as faster to implement and more cost effective than traditional one-at-a-time approach [16][17][18][19][20].…”

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confidence: 99%

Use of Experimental Designs to Evaluate the Influence of Methyl Green Dye as a Corrosion Inhibitor for Carbon Steel in Perchloric Acid

2021

MJCHEM

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The aim of this research study was to apply experimental design in the optimization of influencing parameters on the corrosion inhibition efficiency of Methyl Green (MG) dye using the weight loss (WL) technique. Corrosion inhibition of carbon steel (CS) in the presence of different concentrations of MG dye in 1 M HClO4 solution has been studied. Results showed that inhibition efficiency (IE) increased with increasing concentration of MG dye up to 1.0 × 10 −3 mol/L, and decreased with raising temperature. The free energy values calculated from the Langmuir adsorption isotherm for MG dye (-36.24 to -38.04 kJ/mol) suggested that MG dye molecules adsorbed onto CS surface via a physicochemical mechanism.

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“…Design of an experiment that produces valid and reliable data is not easy. Experimental design has been frequently used in the statistical optimization of analytical approaches because of its advantages such as reduction on the number of experiments that leads to considerably less laboratory work and lower reagent consumption, and it is faster to implement and more cost effective than a traditional one-at-a-time approach. − Development of mathematical models that estimate statistical significance of factors is investigated by experimental design. It also facilitates the evaluation of interaction between influencing variables.…”

Section: Introductionmentioning

confidence: 99%

Experimental and Theoretical Investigation of Inhibition Efficiency of 2-(2-Hydroxyphenyl)-benzothiazole Using Impedance Spectroscopy, Experimental Design, and Quantum Chemical Calculations

Afzalkhah

Masoum

Behpour

et al. 2017

Ind. Eng. Chem. Res.

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The aim of this research study was to apply experimental design in the optimization of influencing parameters on the corrosion inhibition efficiency of 2-(2-hydroxyphenyl)-benzothiazole using electrochemical impedance spectroscopy (EIS). By experimental design, the best measurement for a mixture of 2-(2-hydroxyphenyl)-benzothiazole and ethanol as an impressive corrosion inhibitor for the mild steel in different hydrochloric acid concentrations through studying the surface reaction procedure was investigated. Obtained optimum values by response surface methodology (RSM) were 433.7 μM for inhibitor concentration, 3.38 M for hydrochloric acid, and 0.36 M for ethanol concentration.

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Application of multivariate optimization to electrochemical determination of methyldopa drug in the presence of diclofenac at a nanostructured electrochemical sensor

Cited by 13 publications

References 50 publications

Sensor Modified with Gold Nanoparticles Stabilized in Dialdehyde Starch/DMSO Matrix for Methyldopa Detection

Sensor Modified with Gold Nanoparticles Stabilized in Dialdehyde Starch/DMSO Matrix for Methyldopa Detection

Use of Experimental Designs to Evaluate the Influence of Methyl Green Dye as a Corrosion Inhibitor for Carbon Steel in Perchloric Acid

Experimental and Theoretical Investigation of Inhibition Efficiency of 2-(2-Hydroxyphenyl)-benzothiazole Using Impedance Spectroscopy, Experimental Design, and Quantum Chemical Calculations

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