Abstract:Objective:The arrival of precision medicine plan brings new opportunities and challenges for patients undergoing precision diagnosis and treatment of malignant tumors. With the development of medical imaging, information on different modality imaging can be integrated and comprehensively analyzed by imaging fusion system. This review aimed to update the application of multimodality imaging fusion technology in the precise diagnosis and treatment of malignant tumors under the precision medicine plan. We introdu… Show more
“…MRI permits multi-sequencing and multi-parametric imaging with higher soft tissue resolution than CT, making the actual boundary between tumor and soft tissue more precise, and causes no radiation damage[ 7 ]. MRI-CT image fusion can avoid overestimation of clinical tumor volume by CT images only.…”
Section: Discussionmentioning
confidence: 99%
“…PET-CT image fusion can simultaneously show metabolic activity and anatomical location to achieve a more accurate delineation of GTV and provide more effective protection for the surrounding normal organs and tissues. However, the distribution of 18F-FDG is not limited to malignant tissues; thus, PET-CT fusion images can also lead to false negative and false positive results in tumor diagnosis[ 7 ]. False-positive results in PET-CT may occur due to inflammation, limited spatial resolution, and lack of a standard method for segmentation[ 4 ].…”
BACKGROUND
Accurate delineation of the target area for patients with hypopharyngeal cancer is the key to achieving an ideal radiotherapy effect. Since computed tomography (CT) alone can no longer meet the treatment needs, fusing CT images with magnetic resonance imaging (MRI) or positron emission tomography (PET) images can overcome the disadvantages of CT. Herein, we present a clinical case of hypopharyngeal cancer to delineate the tumor volume using combined MRI-CT and PET-CT fusion images to examine if they could accurately cover the tumor volume.
CASE SUMMARY
A 67-year-old male patient with hypopharyngeal carcinoma could not tolerate chemotherapy and surgery due to complicated health issues such as diabetic nephropathy and other underlying diseases. After multidisciplinary consultations, clinicians eventually agreed to undergo radiotherapy to control the progression of his tumor. He was examined by CT, MRI, and 18-fluorodeoxyglucose-PET for treatment planning, and CT images were fused with PET and MRI images while delineating tumor volume.
CONCLUSION
The image fusion of MRI-CT and PET-CT has both advantages and disadvantages. Compared with CT images alone, the combination of MRI-CT and PET-CT fusion images can precisely cover the gross tumor volume in hypopharyngeal carcinoma and avoid overestimation or incomplete coverage of tumor volume.
“…MRI permits multi-sequencing and multi-parametric imaging with higher soft tissue resolution than CT, making the actual boundary between tumor and soft tissue more precise, and causes no radiation damage[ 7 ]. MRI-CT image fusion can avoid overestimation of clinical tumor volume by CT images only.…”
Section: Discussionmentioning
confidence: 99%
“…PET-CT image fusion can simultaneously show metabolic activity and anatomical location to achieve a more accurate delineation of GTV and provide more effective protection for the surrounding normal organs and tissues. However, the distribution of 18F-FDG is not limited to malignant tissues; thus, PET-CT fusion images can also lead to false negative and false positive results in tumor diagnosis[ 7 ]. False-positive results in PET-CT may occur due to inflammation, limited spatial resolution, and lack of a standard method for segmentation[ 4 ].…”
BACKGROUND
Accurate delineation of the target area for patients with hypopharyngeal cancer is the key to achieving an ideal radiotherapy effect. Since computed tomography (CT) alone can no longer meet the treatment needs, fusing CT images with magnetic resonance imaging (MRI) or positron emission tomography (PET) images can overcome the disadvantages of CT. Herein, we present a clinical case of hypopharyngeal cancer to delineate the tumor volume using combined MRI-CT and PET-CT fusion images to examine if they could accurately cover the tumor volume.
CASE SUMMARY
A 67-year-old male patient with hypopharyngeal carcinoma could not tolerate chemotherapy and surgery due to complicated health issues such as diabetic nephropathy and other underlying diseases. After multidisciplinary consultations, clinicians eventually agreed to undergo radiotherapy to control the progression of his tumor. He was examined by CT, MRI, and 18-fluorodeoxyglucose-PET for treatment planning, and CT images were fused with PET and MRI images while delineating tumor volume.
CONCLUSION
The image fusion of MRI-CT and PET-CT has both advantages and disadvantages. Compared with CT images alone, the combination of MRI-CT and PET-CT fusion images can precisely cover the gross tumor volume in hypopharyngeal carcinoma and avoid overestimation or incomplete coverage of tumor volume.
Recent developments in diagnostic imaging herald a new approach to diagnosis and management of prostate cancer. Multimodality fusion that combines anatomic with functional imaging data has surpassed either of the two alone. This opens up the possibility to “find and fix” malignancy with greater accuracy than ever before. This is particularly important for prostate cancer because it is the most common male cancer in most developed countries. This article describes technical advances under investigation at our institution and others using multimodality image fusion of magnetic resonance imaging (MRI), transrectal ultrasound (TRUS), and PSMA PET/CT (defined as the combination of prostate-specific membrane antigen [PSMA], positron emission tomography [PET], and computed tomography [CT]) for personalized medicine in the diagnosis and focal therapy of prostate cancer with high-intensity focused ultrasound (HiFUS).
“…There are many kinds of malignant tumours, which have different properties, involve different tissues and organs, occur during different stages of diseases, and have different responses to various treatments, so most patients need comprehensive treatment. 2 Surgery is a good way to remove tumours, but it can only eradicate early or earlier solid tumours. 3 Drug therapy is chemotherapy that can kill tumours.…”
Carbon quantum dots (CQDs) are an emerging class of quasi-zero-dimensional photoluminescent nanomaterials with particle sizes less than 10 nm. Owing to their favourable water dispersion, strong chemical inertia, stable optical performance, and good biocompatibility, CQDs have become prominent in biomedical fields. CQDs can be fabricated by "top-down" and "bottom-up" methods, both of which involve oxidation, carbonization, pyrolysis and polymerization. The functions of CQDs include biological imaging, biosensing, drug delivery, gene carrying, antimicrobial performance, photothermal ablation and so on, which enable them to be utilized in antitumour applications. The purpose of this review is to summarize the research progress of CQDs in antitumour applications from preparation and characterization to application prospects. Furthermore, the challenges and opportunities of CQDs are discussed along with future perspectives for precise individual therapy of tumours.
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