Application of micromachine techniques to biotechnological research

Murakami, Yuji; Idegami, Kotaro; Nagai, Hidenori; Kikuchi, Takayuki; Morita, Yasutaka; Yamamura, Akira; Yokoyama, Kenji; Tamiya, Eiichi

doi:10.1016/s0928-4931(00)00160-0

Cited by 17 publications

(8 citation statements)

References 4 publications

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“…In the past, researchers have explored gravity, fluidic forces, capillary forces, and electrostatic and magnetic fields to drive the self-assembly process [2][3][4][5][6]. Most of these methods do not match the full functionality, cost, throughput, or accuracy offered by robotic and manual assembly.…”

Section: Introductionmentioning

confidence: 99%

Part-to-Part and Part-to-Substrate Magnetic Self-Assembly of Millimeter Scale Components with Angular Orientation

Shetye

Eskinazi

Arnold

2009

2009 IEEE 22nd International Conference on Micro Electro Mechanical Systems

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This paper presents multifunctional self-assembly of millimeter scale components using magnetic forces between permanent micromagnets integrated on the component surfaces. Part-to-part assembly is demonstrated by batch assembly of free-floating 1mm x 1mm x 0.5mm silicon parts in a liquid environment with the assembly yield varying from 88% to 9000. Part-tosubstrate assembly is demonstrated by assembling an ordered array on a substrate in a dry environment with the assembly yield varying from 87% to 98%. In both cases, diverse magnetic shapes/patterns are used to control the alignment and angular orientation of the components and assembly times range from 15 -240 s.

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Section: Introductionmentioning

confidence: 99%

Part-to-Part and Part-to-Substrate Magnetic Self-Assembly of Millimeter Scale Components with Angular Orientation

Shetye

Eskinazi

Arnold

2009

2009 IEEE 22nd International Conference on Micro Electro Mechanical Systems

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“…In the past two decades, self-assembly has been used to describe the spontaneous attachment of molecules and millimeter- to micrometer-sized objects to a surface or to themselves. − For example, self-assembly is used to describe events in layer-by-layer assembly, , microcontact printing, , and fluidic self-assembly (FSA) of microcomponents. − Recently, there has been great interest in FSA because of its potential to reduce the cost of assembling components in fabricating, for example, electronic devices and sensors. One of the major technical barriers to low cost fabrication is the ability to cheaply and effectively integrate complex microsystems that may find use in telecommunications, display, chemical analysis, and biomedical instrumentation.…”

Section: Introductionmentioning

confidence: 99%

Thermally Controlled Fluidic Self-Assembly

Sharma

2007

Langmuir

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A novel approach for the fluidic self-assembly (FSA) of microparts in a multibatch process utilizing the thermal behavior of the carrier fluid as a means for selecting binding sites is presented. In the system studied, fluidic assembly takes place due to a capillary bridge between hexadecane deposited on a hydrophobic patch on a substrate and a hydrophobic surface on a micropart suspended in a carrier fluid. When desired, FSA of microparts is prevented by causing the surrounding carrier fluid to form a gel when heated, offering a method for directing self-assembly to sites that are not heated. It is shown that a suitable carrier fluid is 15 wt % Pluronic F127, which gels at about 40 degrees C when tested in the geometry used to demonstrate the concept. Experimental results demonstrating FSA and thermally controlled fluidic assembly (TCFSA) of plastic microparts dispersed in Pluronic F127 solution are presented. Potentially, TCFSA offers a general method for directed assembly as it relies on restricting the transport of microparts to a site rather than interfering with the fundamental attractive forces responsible for self-assembly.

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“…20,21 Velev has exploited the spatial confinement afforded by liquid droplets to direct the crystallization of colloidal spheres, [22][23][24] and we have used a related methodstemplated MESA based on capillary interactions at the interface between two liquids-to generate spherical 25 and quasi-two-dimensional structures. 26,27 Similar approaches by Xia, Ozin, and others have included the crystallization of spherical colloids through confinement in microchannels, 15,28,29 and the selective placement of small objects on patterned surfaces using chemical, 30,31 magnetic, 32 electrostatic, 33 and capillary 34 interactions. Previously, we used capillarity to generate untemplated arrays from 10-µm-sized metallic plates.…”

Section: Introductionmentioning

confidence: 99%

“…Wiltzius and van Blaaderen employed lithographically fabricated reliefs to direct the formation of bulk colloidal crystals with predetermined sizes and lattice structures, and Pouliqen et al extended this strategy to the crystallization of 2-mm-sized spheres . Xia used holes in flat substrates, designed to accommodate a discrete number of spherical colloids, to generate aggregates with defined sizes and structures. , Smith demonstrated shape-selective integration of microelectronic device elements into textured substrates via fluidic self-assembly (FSA). , Velev has exploited the spatial confinement afforded by liquid droplets to direct the crystallization of colloidal spheres, − and we have used a related methodtemplated MESA based on capillary interactions at the interface between two liquids−to generate spherical and quasi-two-dimensional structures. , Similar approaches by Xia, Ozin, and others have included the crystallization of spherical colloids through confinement in microchannels, ,, and the selective placement of small objects on patterned surfaces using chemical, , magnetic, electrostatic, and capillary interactions.…”

Section: Introductionmentioning

confidence: 99%

Template-Directed Self-Assembly of 10-μm-Sized Hexagonal Plates

et al. 2002

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This article presents a strategy for the fabrication of ordered microstructures using concepts of design inspired by molecular self-assembly and template-directed synthesis. The self-assembling components are 4-microm-thick hexagonal metal plates having sides 10 microm in length ("hexagons"), and each template consists of a 4-microm-thick circular metal plate surrounding a central cavity, the perimeter of which is complementary in shape to the external edges of a two-dimensional, close-packed array of hexagons. The hexagons and templates (collectively, "pieces") were fabricated via standard procedures and patterned into hydrophobic and hydrophilic regions using self-assembled monolayers (SAMs). Templated self-assembly occurs in water through capillary interactions between thin films of a nonpolar liquid adhesive coating the hydrophobic faces of the pieces. The hexagons tile the cavities enclosed by the templates, and the boundaries of the cavities determine the sizes and shapes of the assemblies. Curing the adhesive with ultraviolet light furnishes mechanically stable arrays having well-defined morphologies. By allowing control over the structures of the resulting aggregates, this work represents a step toward the development of practical methods for microfabrication based on self-assembly.

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Application of micromachine techniques to biotechnological research

Cited by 17 publications

References 4 publications

Part-to-Part and Part-to-Substrate Magnetic Self-Assembly of Millimeter Scale Components with Angular Orientation

Part-to-Part and Part-to-Substrate Magnetic Self-Assembly of Millimeter Scale Components with Angular Orientation

Thermally Controlled Fluidic Self-Assembly

Template-Directed Self-Assembly of 10-μm-Sized Hexagonal Plates

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