Application of Metal Complexes of Schiff Bases as an Antimicrobial Drug: A Review of Recent Works

Abstract

Schiff bases are versatile ligands which are synthesized from the condensation of primary amines with carbonyl groups. Synthesis of Schiff base transition metal complexes by using Schiff base as ligands appears to be fascinating in view of the possibility of obtaining coordination compounds of unusual structure and stability. These transition metal complexes have received exceptional consideration because of their active part in metalloenzymes and as biomimetic model compounds due to their closeness to natural proteins and enzymes. These compounds are very important in pharmaceutical fields because of their wide spectrum of biological activities. Most of them show biological activities including antibacterial, antifungal, antidiabetic, antitumor, antiproliferative, anticancer, herbicidal, and anti-inflammatory activities. The biological activity of the transition metal complexes derived from the Schiff base ligands has been widely studied. This review summarizes the importance, Scope and antimicrobial activities of Schiff base metal complexes.

Synthesis, Characterization and Biological Efficacies from Some New Dinuclear Metal Complexes for Base 3-(3,4-Dihydroxy-phenyl)-2-[(2-hydroxy-3-methylperoxy-benzylidene)-amino]-2-methyl Propionic Acid

“…The Schiff base ligand Dia Tetrahedral the spectrum shows peaks at 279 and 342 nm lead to (ππ*) and (n-π*) electronic transition [26]. The spectrum of Cr 3+ complex display two peaks at 276 and 364 nm described to ligand felid and charge transfer respectively, other three peaks at 449, 552 and 670 nm which were assigned to electronic transition type 4 A 2 g → 4 T 1 g(p), 4 A 2 g → 4 T 1 g(F) and 4 A 2 g → 4 T 2 g(F) respectively, also the value of the magnetic moment at 3.66 B.M may be taken as additional evidence for octahedral geometry [27]. The spectrum of Mn 2+ complex displays three peaks at 277, 347 and 380 nm due to the ligand field and charge transfer.…”

“…Due to their structural varieties and unique characteristics, these are the most versatile studied ligands in coordination chemistry. Among the Schiff base derivatives, those having phenol moiety have attracted considerable attention due to their wide range of biological activities Metal complexes such as Zn, Cd, Co, Ni, Pd, Ag, and Hg have different biological activities such as antimicrobial [3][4], antifungal [5][6][7], antioxidant [5,8] and anticancer [9][10][11][12]. These type complexes have also many different properties such as catalytic activity, porosity, magnetism, and conductivity [13][14].…”

A Study of the Component Formats Effect on I,onization Constants for A Number Schiff Pyridine Water and Ethanol with Variant Temperature Degrees

“…The products are cooled and filtered. The crude Schiff bases are then recrystallized from ethanol in order to obtain pure compounds as shown in table (1). A stock solutions of (10 -3 M) concentration for each Schiff base is prepared in deionized water.…”

“…Schiff bases are very important compounds that are used in various fields due to their biological activities. They have been used as an antimicrobial agent, fungicides and used for the synthesis of many chemical and drugs [1] 2. The 2-aminopyridine can be considered as a type of the intermediate compounds which can be used for the synthesis of many pharmaceutical compounds specially the anti-histamine [2].…”

Preparation, characterization and biological activity study of Co (II), Ni(II) and Cu(II) Complexes with 4-(( Z)-4-bromobenzylidene)-2-(7-((4-bromobenzylidene) amino)-3-methyl-8-oxo-5-thia-1-azabicyclo [4.2.0] oct-2-en-2-yl)-oxazol-5(4H)-one derivatives

“…Also, they are utilized in various research areas because of the fact that they can be produced easily, also their wide range applications [1][2][3][4][5][6][7]. In addition, the Schiff bases were stemmed from the amino and carbonyl compounds significant ligand's class which coordinate to metal ions via azomethine nitrogen, oxygen or sulphur [8][9][10][11][12][13]. Schiff bases act as bi-, tri-, tetra-or multidentate ligands [14][15].…”