Preparation, characterization and biological activity study of Co (II), Ni(II) and Cu(II) Complexes with 4-(( Z)-4-bromobenzylidene)-2-(7-((4-bromobenzylidene) amino)-3-methyl-8-oxo-5-thia-1-azabicyclo [4.2.0] oct-2-en-2-yl)-oxazol-5(4H)-one derivatives

Abstract

New succession related to the transition metal complexes Cu(II), Ni(II), and Co(II) with 4-((Z)-4-bromobenzylidene)-2-(7-((4bromobenzylidene)amino)-3methyl-8oxo-5-thia-1azabicyclo[4.2.0]oct-2-en-2yl)oxazol-5(4H)-one) has been prepared and described. The structural descriptions have been reached from FT-IR, UV Vis-Spectrophotometer, molar conductance measurements, magnetic susceptibility, atomic absorption techniques as well as 1 HNMR. Based on these results, it is proposed that the coordinates of the ligand to metal ions from the nitrogen related to azomethine group as well as the oxygen of carbonyl group. In addition, the biological activity of the complexes and the ligand has been investigated opposite Staphylococcus aureus, Aspergillus Niger, E.coli, and Candida albicans. The products indicate that Co (II)-complex, Ni (II)-complex and Cu (II) -complex is the enhanced biological activity in comparison to the ligand.