Application of Membrane-Selective Electrodes for the Determination of Pioglitazone Hydrochloride in the Presence of Its Acid Degradant or Metformin Hydrochloride in Tablets and Plasma

Validated sensitive spectrofluorimetric method for determination of antihistaminic drug azelastine HCl in pure form and in pharmaceutical dosage forms: application to stability study

“…Moreover, our method is one of the most sensitive reported for the determination of AZL, permitting determination of the drug at the ng level and facilitating its quantitation in metered dose nasal sprays. The proposed method has been found to be ~20–50 times more sensitive than the previously reported method ; in addition, the proposed method does not require complicated set‐up, unlike another method reported in the literature that needs a sophisticated LC–MS instrument .…”

“…A review of the literature revealed several analytical methods for the determination of AZL in either its pure or dosage forms, including spectrophotometry , electrochemical methods , thin‐layer chromatography (TLC) high‐performance liquid chromatography (HPLC) and liquid chromatography–tandem mass spectrometry (LC/MS/MS) . However, all these methods use expensive instruments and tedious procedures.…”

Crystal structure of 1-(3-chloropropyl)piperidin-1-ium tetraphenylborate, C32H37BClN

“…Sodium tetraphenylborate is a popular precipitating reagent [5]. It is also used as association for construct of sensing material used in chemical sensors [6][7][8][9]. The title compound crystallizes with one cation N-(3-chloropropyl) piperidinum ion and anion tetraphenylborate in the asymmetric unit (cf.…”

A systematic and critical review on bioanalytical method validation using the example of simultaneous quantitation of antidiabetic agents in blood

“…We observed two reasons for the absence of validation data in the articles: the study was performed before the guidelines had been published [53][54][55][56][57][58][59][60][61][62][63][64][65][66]; and the study focus was on method development and validation was not addressed [67][68][69][70][71][72]. Other reasons for excluding articles were: non-simultaneous method [74][75][76][77], inappropriate sample preparation [78,79], literature review [80], animal plasma sample [81], language in non-Roman characters [82][83][84], validation of only one analyte [85,86], and pharmacokinetic studies (PK) that used a previously developed and validated method [87][88][89][90][91][92][93][94][95][96][97].…”