Application of Membrane-Selective Electrodes for the Determination of Naftidrofuryl Oxalate in the Presence of Its Alkaline Degradant in Tablets and Plasma

Abbas, Samah S.; Zaazaa, Hala E.; Ghobashy, Mohamed Mohamady; Fayez, Yasmin M.; Fattah, S. Abd El

doi:10.4152/pea.201203177

Cited by 5 publications

(9 citation statements)

References 6 publications

(5 reference statements)

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“…The results reveal that, as ionophore provided high stability to the complexes formed with cationic drug present in solution; thus, the membrane selectivity and sensitivity are substantially enhanced. Thus, in the absence of ionophores as in references [24,25], the lowest slope value is found accompanied by the highest selectivity coefficient values. A higher selectivity coefficient value corresponds with more attack by interfering cations on the electrode membrane.…”

Section: Performance Characteristics Of Nft Sensorsmentioning

confidence: 87%

“…The sulphonated calyx-8-arene-based showed the best Nernstian slope (56.4 and 54.1 mV/decade) and selectivity coefficient values compared to reference [25] that used β-cyclodextrin as ionophore. The host-guest complex is stabilized via an electrostatic interaction between the cationic NFT and anionic sulphonated calyx-8-arene.…”

Section: Performance Characteristics Of Nft Sensorsmentioning

confidence: 99%

“…Ion selective electrodes have been reported for the determination of NFT using a precipitation-based technique with dipicrylamine [24] tetra phenyl borate & ammonium reineckate [25] as an anionic exchanger without incorporation of ionophores& using a β-cyclodextrin as ionophore without incorporation of ion association complex. Also their selectivity coefficients were only tested for a few organic and inorganic cations.…”

Section: Introductionmentioning

confidence: 99%

“…It is also licensed for the treatment of intermittent claudication due to peripheral arterial disease [2]. Several methods have been reported for the determination of naftidrofuryl (NFT), these include titrimetric method [3], spectrophotometric [4][5][6][7] high performance liquid chromategraphic [8][9][10][11][12][13][14], thin layer chromatographic [7] capillary zone electrophoresis [15][16][17], phosphorimetric [18][19][20][21][22][23], electrochemical [5,24,25] and chemometric [13] methods.…”

Section: Introductionmentioning

confidence: 99%

“…From these procedures, only the spectroscopic [7] HPLC techniques [9,13,14], TLC [7] and electrochemical [25] were recommended as stability indicating assays. Ion selective electrodes have been reported for the determination of NFT using a precipitation-based technique with dipicrylamine [24] tetra phenyl borate & ammonium reineckate [25] as an anionic exchanger without incorporation of ionophores& using a β-cyclodextrin as ionophore without incorporation of ion association complex.…”

Section: Introductionmentioning

confidence: 99%

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The use of calixarene as ionophores in potentiometric ion-selective electrodes of naftidrofuryl oxalate using microsized membrane sensors for kinetic study of naftidrofuryl (NFT) degradation

El-Sayed

2013

Eur. J. Chem.

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KEYWORDSNovel miniaturized polyvinyl chloride membrane sensors in all-solid state graphite and platinum wire supports were developed, electrochemically evaluated and used for the assay of naftidrofuryl oxalate. The naftidrofuryl oxalate sensors were based on the formation of an ionassociation complex between the drug cation and tetrakis-(4-chlorophenyl)borateanionic exchanger as electroactive material and sulfocalix-8-arene as ionophore dispersed in a polyvinyl chloride matrix. Linear responses of 10 -2 -10 -6 M and 10 -2 -10 -5 M with cationic slopes of 56.9 mV and 54.1 mV over the pH range 2-5 were obtained by using the naftidrofuryl oxalate-coated graphite (Sensor 1) and platinum wire (Sensor 2) membrane sensors, respectively. The utility of 4-sulfocalix-8-arene as ionophore had a significant influence on increasing the membrane sensitivity and selectivity. The methods were also used to determine the intact drug in the presence of it's degradate in Praxilene ® tablets, plasma and cerebrospinal fluid with good recovery. Sensor 1 was used to study the kinetics of naftidrofuryl oxalate alkaline degradation that was found to follow a pseudo first-order reaction. The activation energy could be estimated from the Arrhenius plot to be 12.572 Kcal/mol. PotentiometryCerebrospinal fluid 4-Sulfocalix-8-arene Naftidrofuryl oxalate Stabilityindicating method Tetrakis-(4-chlorophenyl)borate

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Section: Performance Characteristics Of Nft Sensorsmentioning

confidence: 87%

Section: Performance Characteristics Of Nft Sensorsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

The use of calixarene as ionophores in potentiometric ion-selective electrodes of naftidrofuryl oxalate using microsized membrane sensors for kinetic study of naftidrofuryl (NFT) degradation

El-Sayed

2013

Eur. J. Chem.

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Application of π acceptors to the spectrophotometric and spectrofluorimetric determination of vincamine and naftidrofuryl oxalate in their pharmaceutical preparations

et al. 2016

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Three different spectrophotometric and two spectrofluorimetric methods have been developed and validated for the determination of vincamine (VN) and naftidrofuryl oxalate (NF) in tablets. The spectrophotometric methods depend on charge transfer complex formation between each of VN and NF with 7,7,8,8-tetracyano-quinodimethane (TCNQ), 2,6-dichloroquinone-4-chloroimide (DCQ) and 2,3-dichloro-5,6-dicyano-1,4-benzoquinone (DDQ) at 843, 580 and 588 nm, respectively. The spectrofluorimetric methods are based on the formation of charge transfer complex between each of the two drugs and TCNQ, with measurement of the fluorophore formed at 312/375 and 284/612 nm, respectively, or with DDQ at 400/475 and 284/396 nm, respectively. In the spectrophotometric measurements, Beer's law was obeyed at concentration ranges of 1.5-16, 10-180 and 12-140 μg/ml for VN with TCNQ, DCQ, and DDQ, respectively. For NF, the corresponding concentrations were 2-28, 5-75 and 25-150 μg/ml with TCNQ, DCQ, and DDQ, respectively. In the spectrofluorimetric measurements, the ranges for VN were 0.05-0.9 and 0.3-4 μg/ml with TCNQ and DDQ, respectively, whereas for NF the ranges were 0.05-0.85 and 0.5-8 μg/ml with TCNQ and DDQ, respectively. The different experimental parameters affecting the development and stability of the formed color or fluorophore were studied and optimized and the molar ratios of the complexes were calculated. The proposed methods were validated according to ICH guidelines and were successfully applied for the determination of VN and NF in their tablet dosage forms.

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Nanoparticle-Enhanced Potentiometric Ion-Selective Electrodes for Therapeutic Drug Monitoring of Linezolid

El-Sayed

Al‐Ghobashy

Attia

et al. 2019

J. Electrochem. Soc.

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Nosocomial infections caused by multidrug-resistant (MDR) bacteria is treated with Linezolid (LIN) either alone or with other medications such as; Meropenem (MERO) or Theophylline (THEO). LIN has variable pharmacokinetics which makes it an ideal candidate for therapeutic drug monitoring (TDM). Ion selective electrode (ISE) is a promising tool that can be used in hospitals by medical practitioners to adjust the dose of LIN which will eventually improve the therapeutic outcomes. Four potentiometric PVC sensors were fabricated for the determination of LIN in plasma in the presence of co-administered medications (MERO and THEO). Sensor I; cationic exchanger phosphotungstate sensor covering a concentration range of 1.0 × 10 −7 -1.0 × 10 −4 M. while Sensor II; 2-hydroxypropyl-β-cyclodextrin (HP-βCD) sensor covered a concentration range of 1.0 × 10 −9 -1.0 × 10 −3 M. The last two sensors were fabricated using metal nanoparticles (NPs). Sensor III; Copper NP-incorporated HP-βCD sensor was used over a concentration range 1.0 × 10 −9 -1.0 × 10 −3 M, while Sensor IV; Cobalt NP-incorporated HP-βCD sensor attained the highest sensitivity of all the prepared sensors with the quantification range of 1.0 × 10 −10 -1.0 × 10 −4 M. Britton-Robinson buffer at pH 3.5 ± 0.5 was chosen for optimization of experimental conditions of the four sensors. The proposed sensors performance was validated according to IUPAC\FDA guidelines and was applied successfully for the determination of LIN in its pharmaceutical formulation and for TDM in incurred plasma samples. No interference was noted in the presence of (MERO) and (THEO) that are commonly co-administered with LIN as a part of the treatment protocol for healthcare-associated pneumonia (HCAP).

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Application of Membrane-Selective Electrodes for the Determination of Naftidrofuryl Oxalate in the Presence of Its Alkaline Degradant in Tablets and Plasma

Cited by 5 publications

References 6 publications

The use of calixarene as ionophores in potentiometric ion-selective electrodes of naftidrofuryl oxalate using microsized membrane sensors for kinetic study of naftidrofuryl (NFT) degradation

The use of calixarene as ionophores in potentiometric ion-selective electrodes of naftidrofuryl oxalate using microsized membrane sensors for kinetic study of naftidrofuryl (NFT) degradation

Application of π acceptors to the spectrophotometric and spectrofluorimetric determination of vincamine and naftidrofuryl oxalate in their pharmaceutical preparations

Nanoparticle-Enhanced Potentiometric Ion-Selective Electrodes for Therapeutic Drug Monitoring of Linezolid

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