Application of Maxblend Fermentor® for microbial processes

Hiruta, Osamu; Yamamura, Kenji; Takebe, Hidehi; Futamura, Takafumi; Iinuma, Katsuharu; Tanaka, Hideo

doi:10.1016/s0922-338x(97)87331-x

Cited by 44 publications

(21 citation statements)

References 15 publications

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“…The aeration rate was 1 vvm, and the concentration of dissolved oxygen (DO) was controlled above 10% air saturation by mixing the inlet air with oxygen when necessary. Agitation was achieved with a gate impeller similar to that of Hiruta et al [12], and an agitator speed of 400 rpm was used.…”

Section: Methodsmentioning

confidence: 99%

Production of hyaluronic acid by repeated batch fermentation

Huang

Chen

2008

Biochemical Engineering Journal

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Section: Methodsmentioning

confidence: 99%

Production of hyaluronic acid by repeated batch fermentation

Huang

Chen

2008

Biochemical Engineering Journal

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“…Agitation systems are critical in the bioreactors as was shown by Hiruta et al [79]. These authors compared the Maxblend impeller to turbine impeller in agitated fermenters and showed that the mixing capacity of the Maxblend impeller was higher.…”

Section: Modes Of Cultivation For Microbial Lipid Productionmentioning

confidence: 98%

Microbial lipids from renewable resources: production and characterization

Ramalingam

Dufreche

Zappi

et al. 2010

J Ind Microbiol Biotechnol

268

147

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A number of microorganisms belonging to the genera of algae, yeast, bacteria, and fungi have ability to accumulate neutral lipids under specific cultivation conditions. The microbial lipids contain high fractions of polyunsaturated fatty acids and have the potential to serve as a source of significant quantities of transportation fuels. This paper reviews the current state of the art of this field. It summarizes the various microorganism used, feed stocks available, environmental factors that influence growth of cells and accumulation of lipids, major fatty acid composition of lipids, and the technology.

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“…The dissolved oxygen level was maintained at 20% of air saturation by increasing the aeration rate and/or supplementing pure oxygen. A gate impeller, similar to that of Hiruta et al [14], with a speed of 300 rpm was used for agitation.…”

Section: Batch Fermentationmentioning

confidence: 99%

Fermentation process development for hyaluronic acid production by Streptococcus zooepidemicus ATCC 39920

Chen

Huang

et al. 2009

Korean J. Chem. Eng.

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The development of a fermentation strategy for hyaluronic acid (HA) production by Streptococcus zooepidemicus ATCC 39920 has been explored. The specific HA productivity (Y P/X ) was affected by the medium carbon-tonitrogen (C/N) ratio rather than the specific growth rate of cells. Accordingly, HA fermentation should be performed in a balanced medium with an optimum C/N ratio of 2 : 1 in a batch culture. To improve the performance of the batch culture, the operation conditions for the fill-and-draw culture were investigated. It was found that the timing of medium exchange is critical for successfully performing fill-and-draw operations. Since streptococcal cells at the stationary phase might lose the capacity of HA synthesis, the displacement of the medium in a fill-and-draw culture should be started at the late exponential growth phase.

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Application of Maxblend Fermentor® for microbial processes

Cited by 44 publications

References 15 publications

Production of hyaluronic acid by repeated batch fermentation

Production of hyaluronic acid by repeated batch fermentation

Microbial lipids from renewable resources: production and characterization

Fermentation process development for hyaluronic acid production by Streptococcus zooepidemicus ATCC 39920

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