Application of Mathematical Models in Drug Release Kinetics of Lagerstroemia Speciosa Extract-Phospholipid Complex

Abstract

The aim of present work is to govern and scrutinize the kinetics of drug release from the complex by employing various mathematical models. A study was done with Lagerstroemia speciosa extract-phospholipid complex, 50 mg/200mg by employing anticipation precipitation technique using soya lecithin and cholesterol as complex forming polymer. In-vitro drug release profile was carried out in phosphate buffer saline, pH 7.4 (900mL) using USP dissolution apparatus II (Paddle) at 50 RPM at an extended time period of 0.5, 0.75, 1, 1.5, 2, 2.5, 3 and 4 hours. The drug release data was obtained, quantitatively correlated and interpreted with various mathematical models viz. Zero order model, first order model, Higuchi model and Korsmeyer-Peppas model and evaluated to understand the kinetics of drug release. The criterion for the most suitable model was based on the high degree of coefficient of correlation of drug release profile was best fitted with Korsmeyer-Peppas model and follows drug release kinetics which is diffusion controlled.