Solid Dispersions: An Effective Technology for Improving Dissolution Kinetics of Poorly Soluble Drugs
Ranim Alrouhayyah,
Tatiana F. Sheshko,
Svetlana N. Suslina
et al.
Abstract:Solid dispersions are one of the essential technologies for improving solubility and dissolution kinetics of drugs. They can be prepared in several ways and using different carriers. This technique is very suitable for class II BCS drugs, one of which is mefenamic acid. This paper is devoted to improving the solubility and dissolution rate of mefenamic acid by preparing solid dispersions using polyethylene glycol 4000, polyvinylpyrrolidone K30, and polysorbate 80 as carriers. Solid dispersions were prepared by… Show more
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