Application of magnetically immobilized edible fungus for the biotransformation of panax notoginseng saponin Rb1 to Rd and Rg3

Zang, Yu-Ping; Guo, Na; Jiao, Jiao; Wang, Xiqing; Gai, Qing-Yan; Xu, Wenjing; Fu, Yujie

doi:10.1016/j.jchromb.2017.07.038

Cited by 11 publications

(3 citation statements)

References 38 publications

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“…The levels of PPD-type ginsenosides (Rb1, Rb2, Rc, and Rd), PPT-type ginsenosides (notoginsenoside R1) decreased, whereas the levels of PPD and PPT increased with increasing fermentation period. Using microbial enzymes for the conversion of major ginsenosides in P. notoginseng to bioactive components is valuable in the development of ginseng-based products ( Wang et al, 2011 ; Zang et al, 2017 ). Liu et al (2010) described that Aspergillus niger can convert ginsenoside-Rf into PPT by glycosidase, and the β -glucosidase secreted from Aspergillus plays a key role in the hydrolysis of biomass ( Sørensen et al, 2011 ).…”

Section: Discussionmentioning

confidence: 99%

“…Ample research in recent years has been focused on microbiota-mediated biotransformation ( Koppel et al, 2017 ). Immobilized edible fungi, such as Aspergillus , Monascus , Rhizopus , yeast, and Mucor, have also been utilized for biotransformation and efficient, natural bioactive metabolite production in industries ( Zang et al, 2017 ). Aspergillus cristatus (synonym: Eurotium cristatum ), termed as the “Golden Flowers Fungus” because of its yellow cleistothecium color, is a dominant fungal species utilized in the fermentation of Chinese brick tea ( Ge et al, 2016 ; Ren et al, 2017 ).…”

Section: Introductionmentioning

confidence: 99%

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Solid-State Fermentation With Aspergillus cristatus Enhances the Protopanaxadiol- and Protopanaxatriol-Associated Skin Anti-aging Activity of Panax notoginseng

Lee

Reddy

Ryu³

et al. 2021

Front. Microbiol.

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A metabolomics approach was used to profile metabolites of Panax notoginseng fermented with Aspergillus cristatus in two ways, liquid-state fermentation (LF-P) and solid-state fermentation (SSF-P) and examine metabolite markers representing antioxidant activity and skin anti-aging. Protopanaxadiol (PPD) and protopanaxatriol (PPT) contents were higher in SSF-P than in LF-P and showed a multiplicative increase over the fermentation period of four days. PPD and PPT levels also correlated with antioxidant and anti-aging effects in skin, based on the mRNA expression of dermal extracellular matrix components. In the bioactivity validation assays, PPD and PPT significantly improved the expression of type-I collagen, fibrillin-1, and elastin in human dermal fibroblasts from both young and old subjects; these were comparable with the effects of the SSF-P extracts. Overall, our results suggest that changes in the metabolites of P. notoginseng fermented with A. cristatus enhance the quality and availability of bioactive compounds associated with skin anti-aging.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Solid-State Fermentation With Aspergillus cristatus Enhances the Protopanaxadiol- and Protopanaxatriol-Associated Skin Anti-aging Activity of Panax notoginseng

Lee

Reddy

Ryu³

et al. 2021

Front. Microbiol.

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“…Common Ginsenosides (high content) account for more than 80% of the total Ginsenosides in ginseng root, such as Rb1 and Rb2 (Kochan et al, 2017;Wang et al, 2020a). The content of Rb1 is the highest in common Ginsenosides, while that of rare Ginsenosides such as F2 is low (Zang et al, 2017;Chen et al, 2020;Wang et al, 2011). Most of the minor ginsenosides generally exhibit good pharmacological activities.…”

Section: Introductionmentioning

confidence: 99%

Simultaneous transformation of ginsenoside Rb1 into rare ginsenoside F2 and Compound K by the extracellular enzyme from Aspergillus Niger Wu-16

Yang

Cao

et al. 2023

Bioresource Technology Reports

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Separation and purification of plant terpenoids from biotransformation

Chen

Pang

Luo

et al. 2021

Engineering in Life Sciences

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The production of plant terpenoids through biotransformation has undoubtedly become one of the research hotspots, and the continuous upgrading of the corresponding downstream technology is also particularly important. Downstream technology is the indispensable technical channel for the industrialization of plant terpenoids. How to efficiently separate high‐purity products from complex microbial fermentation broths or enzyme‐catalyzed reactions to achieve high separation rates, high returns and environmental friendliness has become the focus of research in recent years. This review mainly introduces the common separation methods of plant terpenoids based on biotransformation from the perspectives of engineering strain construction, unit separation technology, product properties and added value. Then, further attention was paid to the application prospects of intelligent cell factories and control in the separation of plant terpenoids. Finally, some current challenges and prospects are proposed, which provide possible directions and guidance for the separation and purification of terpenoids and even industrialization.

show abstract

Application of magnetically immobilized edible fungus for the biotransformation of panax notoginseng saponin Rb1 to Rd and Rg3

Cited by 11 publications

References 38 publications

Solid-State Fermentation With Aspergillus cristatus Enhances the Protopanaxadiol- and Protopanaxatriol-Associated Skin Anti-aging Activity of Panax notoginseng

Solid-State Fermentation With Aspergillus cristatus Enhances the Protopanaxadiol- and Protopanaxatriol-Associated Skin Anti-aging Activity of Panax notoginseng

Simultaneous transformation of ginsenoside Rb1 into rare ginsenoside F2 and Compound K by the extracellular enzyme from Aspergillus Niger Wu-16

Separation and purification of plant terpenoids from biotransformation

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