Application of ionic liquid–TiO2 nanoparticle modified carbon paste electrode for the voltammetric determination of benserazide in biological samples

Ensafi, Ali A.; Bahrami, Hadi; Rezaei, Behzad; Karimi-Maleh, Hassan

doi:10.1016/j.msec.2012.11.008

Cited by 85 publications

(20 citation statements)

References 29 publications

(29 reference statements)

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“…1, which is related to omeprazole. [48][49][50][51][52][53][54][55][56][57][58][59][60][61] As a continuation of previous work, 62-68 the use of MWCNTs and the ionic liquid BMIMPF 6 , based on their synergy to form a novel composite thin-film material at a GCE, is described herein for the electrochemical determination of LNS in commercial tablet form. 1 LNS is effective in the treatment of various peptic diseases, including duodenal ulcers, peptic ulcer, reflux esophagitis and ELECTROCHEMICAL BEHAVIOR AND DETERMINATION OF LANSOPRAZOLE 41 ing to the literature, 47 MWCNTs are untangled after treatment with RTILs, mainly because of cross-linking of the nanotube bundles mediated by local molecular ordering of the RTIL resulting from "cation-π" interactions between imidazolium and nanotubes.…”

Section: Introductionmentioning

confidence: 99%

Electrochemical behavior of lansoprazole at a multiwalled carbon nanotubes-ionic liquid modified glassy carbon electrode and its electrochemical determination

You

Zhan

Zuo-ning

2014

JSCS

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The electrochemical behavior of lansoprazole (LNS) was investigated at a glassy carbon electrode (GCE) and the GCE modified by a gel containing multiwalled carbon nanotubes (MWCNTs) and a room-temperature ionic liquid (RTIL) of 1-butyl-3-methylimidazolium hexafluorophosphate (BMIMPF 6 ) in 0.10 M phosphate buffer solution of pH 6.8. It was found that an irreversible anodic oxidation peak with an E pa of 1.060 V SCE appeared at the MWCNTs--RTIL/GCE. Under the optimized experimental conditions a linear calibration curve was obtained over the concentration range from 5.0 μM to 0.20 mM by differential pulse voltammetry with a limit of detection (LOD, S/N = 3) of 0.28 μM. In addition, the novel MWCNTs-RTIL/GCE was also characterized by electrochemical impedance spectroscopy and the proposed method was successfully applied in the quantitative electrochemical determination of LNS content in commercial tablet samples. The determination results met the determination requirements.

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Section: Introductionmentioning

confidence: 99%

Electrochemical behavior of lansoprazole at a multiwalled carbon nanotubes-ionic liquid modified glassy carbon electrode and its electrochemical determination

You

Zhan

Zuo-ning

2014

JSCS

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“…In this regard, as electrode surface modifiers, TiO 2 nanoparticles captured the copious interest of researchers and a considerable amount of research was executed in the previous decades, due to its photocatalytic effect, porosity, steadiness, crystallinity, widespread bandgap, high surface area and low toxicity. [27][28][29] Nonetheless, the narrow photocatalytic z E-mail: dr.npshetti@gmail.com area, large band hole and poor adsorption limit due to the short existence of electron-hole pairs are the significant drawbacks of TiO 2 nanoparticles. 30 The augment in the efficiency of TiO 2 such as to entrap the charge carrier is achieved by doping with transition metals such as silver (Ag), copper (Cu), ruthenium (Ru) etc.. [31][32][33] Actually, on the semiconductor surface, dopants act as an electron sink which diminishes the electron-hole pair recombination.…”

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confidence: 99%

Electrochemical Sensor Based upon Ruthenium Doped TiO₂Nanoparticles for the Determination of Flufenamic Acid

Shetti

Nayak

Malode

et al. 2016

J. Electrochem. Soc.

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In the current research, ruthenium stood a conspicuous dopant for TiO 2 nanoparticles, to enhance its catalytic activity. The characterization of synthesized nanoparticles was accomplished by utilizing XRD, SEM, EDX and TEM analysis. The sensing surface morphology was studied by AFM analysis. Further, we established the electrochemical behavior and detection of flufenamic acid (FFA) by utilizing ruthenium doped TiO 2 nanoparticles modified carbon paste electrode (Ru-TiO 2 /CPE) at pH 6.0 by employing different voltammetric techniques. Modification enhances the electro-oxidation of flufenamic acid with increased current intensity. The influence of parameters like scan rate, pH, accumulation time, amount of the modifier and concentration on the peak current of the drug were studied. The effect of FFA concentration variation was studied using square wave voltammetric (SWV) technique and got lowest detection limit compared to reported techniques. The fabricated sensor was employed for the determination of flufenamic acid in biological samples. Flufenamic acid (FFA), N-(α,α,α-trifluoro-m-tolyl) an anthranilic acid derivative (Scheme 1), is an effective analgesic, an antiinflammatory and antipyretic agent used for the relief of pain and inflammation associated with musculoskeletal and joint disorders, peri-articular and soft tissue disorders, antirheumatic therapy.1,2 Monitoring of therapeutic drug habitually necessitates its detection in biological fluids.Many analytical methods based on different principles, such as spectrophotometry, 3-6 spectrofluorimetry, 5,11 fluorescence spectrometry, 7-10 flow injection analysis, 11,12 chromatography [13][14][15] have been developed for the analysis of flufenamic acid along with its derivatives. Capillary electrophoresis [16][17][18] is an alternative methodology for the separation and detection of FFA. However, these methods are well-demonstrated and broadly accepted, but they require moderately costly equipment, laborious sample pretreatment, specialized expertise, high cost and are time-consuming which make them unsuitable for routine analysis. Few voltammetric studies 5,19 were also carried out by utilizing cyclic voltammetry and adsorptive voltammetry. Though, these sensors suffer from the less sensitive, poor long-term stability, lack of surface renewability, etc.As of late, research developed, aiming at the construction and the characterization of the electrodes composed of carbonaceous materials because of their rich surface chemistry, lower background current, wider potential window, uncomplicated surface renewal and low detection limit properties. [20][21][22][23][24] The fabrication of the working electrode with nanoparticles enhances peak current, sensitivity, reproducibility. 25,26 In current science and technology, one of the crucial uniqueness is to survey and to discover the new efficient materials as electrode surface modifiers.In general, new types of sensor devices are the outcome of the synthesis and preparation of innovative modifiers. In this regard, as e...

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“…It is noteworthy that the methodology of modification of the surface of the GCE is rapid and that the data obtained when compared with those present in the literature [23,[26][27][28][29][30][31][32][33] has performance as good as the sensors described; however, the preparation methodology of some is more laborious than the proposal in this work.…”

Section: Application In Pharmaceutical Formulationmentioning

confidence: 97%

An Electrochemical Sensor Based on Electroreduction of Graphene Oxide on a Glassy Carbon Electrode Using Multiple Pulse Amperometry for Simultaneous Determination of L-Dopa and Benserazide

Barbosa¹,

Oliveira²,

Pereira³

2020

Graphene Production and Application

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In this work, we described the development an electrochemical sensor based on electroreduction of graphene oxide (rGO) on a glassy carbon electrode (GCE) for simultaneous determination of l-Dopa and benserazide. For the elaboration of the GCE/rGO, the developed methodology was based on the electrochemical technique: multiple pulse amperometry (MPA). The MPA was more stable and efficient for the formation of rGO film, under optimum conditions (pH 6.00; concentration of rGO 2.00 mg mL −1 ; time 450 s; potentials −0.60, −0.70, −0.80, −0.90, −0.95, −1.00, −1.10, −1.20, and -1.30 V). After the film was formed, the cyclic voltammetry was used to detect LD and BZ in real samples and optimized conditions 0.05 mol L −1 PBS (pH 5.50). The linear range for the LD is 25-425 μmol L −1 and the BZ of 5-80 μmol L −1 . The limit of detection calculated was 17.10 (LD) and 2.99 (BZ) μmol L −1 .

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Application of ionic liquid–TiO2 nanoparticle modified carbon paste electrode for the voltammetric determination of benserazide in biological samples

Cited by 85 publications

References 29 publications

Electrochemical behavior of lansoprazole at a multiwalled carbon nanotubes-ionic liquid modified glassy carbon electrode and its electrochemical determination

Electrochemical behavior of lansoprazole at a multiwalled carbon nanotubes-ionic liquid modified glassy carbon electrode and its electrochemical determination

Electrochemical Sensor Based upon Ruthenium Doped TiO₂Nanoparticles for the Determination of Flufenamic Acid

An Electrochemical Sensor Based on Electroreduction of Graphene Oxide on a Glassy Carbon Electrode Using Multiple Pulse Amperometry for Simultaneous Determination of L-Dopa and Benserazide

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Application of ionic liquid–TiO2 nanoparticle modified carbon paste electrode for the voltammetric determination of benserazide in biological samples

Cited by 85 publications

References 29 publications

Electrochemical behavior of lansoprazole at a multiwalled carbon nanotubes-ionic liquid modified glassy carbon electrode and its electrochemical determination

Electrochemical behavior of lansoprazole at a multiwalled carbon nanotubes-ionic liquid modified glassy carbon electrode and its electrochemical determination

Electrochemical Sensor Based upon Ruthenium Doped TiO2Nanoparticles for the Determination of Flufenamic Acid

An Electrochemical Sensor Based on Electroreduction of Graphene Oxide on a Glassy Carbon Electrode Using Multiple Pulse Amperometry for Simultaneous Determination of L-Dopa and Benserazide

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Electrochemical Sensor Based upon Ruthenium Doped TiO₂Nanoparticles for the Determination of Flufenamic Acid