Application of immunocytochemical and molecular analysis of six genes in liquid‐based endometrial cytology

Munakata, Satoru; Yamamoto, Takatsugu

doi:10.1002/dc.24903

Cited by 2 publications

(3 citation statements)

References 26 publications

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“…In our previous study, immunocytochemistry and driver gene mutation of six genes were studied by using LBC cytology sample. 33 Akahane et al also used LBC samples and made next-generation sequencing analysis giving compatible results with those of formalin-fixed paraffin-embedded tissue. 34,35 Their study extends the possibility of utilizing the LBC materials to multiple gene analysis by next generation sequencer.…”

Section: Diagnostic Classification Of Endometrial Cytologymentioning

confidence: 99%

“…Recently, molecular analysis was employed on endometrial cytology. In our previous study, immunocytochemistry and driver gene mutation of six genes were studied by using LBC cytology sample 33 . Akahane et al also used LBC samples and made next‐generation sequencing analysis giving compatible results with those of formalin‐fixed paraffin‐embedded tissue 34,35 .…”

Section: Introductionmentioning

confidence: 99%

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Diagnostic value of endometrial cytology and related technology

Munakata

2022

Diagnostic Cytopathology

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Background Endometrial cytology is not much popular in the world, but is commonly used in a few countries. Although cytomorphological evaluation of endometrial cytology is complicating, recent advance in technology helps improve diagnostic accuracy. In addition, new reporting system, The Yokohama System, has been introduced as a standard reporting system resembling The Bethesda System of the uterine cervical cytology. Although sample standardization is one of the causes in diagnostic problem, it was solved by liquid‐based cytology (LBC) technology. In addition, standardized diagnostic algorithm by cytomorphological assessment of LBC samples, the Osaki Study Group (OSG) method, was recently proposed as a reliable and reproducible method. LBC can be utilized for ancillary methods. Application of immunocytochemistry and molecular technology on endometrial cytology samples has been studied to improve diagnostic accuracy. Recent progress of molecular technology has revealed many driver gene mutations in endometrial cancer and its precursors. Surprisingly, many studies revealed that even normal endometrial tissue had driver gene mutations. Conclusion Based on the recent advance in knowledge of molecular profile of endometrial lesions and normal endometrial tissue, endometrial cytology will gain much power in clinical usefulness.

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Section: Diagnostic Classification Of Endometrial Cytologymentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Diagnostic value of endometrial cytology and related technology

Munakata

2022

Diagnostic Cytopathology

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“…The standardized diagnostic algorithm using cytomorphological assessment of LBC samples, also known as the Osaki Study Group method, has recently been demonstrated to be reliable and reproducible [ 11 ]. The application of immunocytochemistry and molecular technology techniques for endometrial cytology sample processing has been studied to improve the diagnostic accuracy of endometrial cytology [ 12 , 13 , 14 , 15 , 16 , 17 , 18 ]. Endometrial biopsy mainly includes D&C, hysteroscopy and hysterectomy.…”

Section: Introductionmentioning

confidence: 99%

Endometrial Cytology in Diagnosis of Endometrial Cancer: A Systematic Review and Meta-Analysis of Diagnostic Accuracy

Wang

Jiang

Yao

et al. 2023

JCM

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Background: Because the incidence of endometrial cancer has been increasing every year, it is important to identify an effective screening method for it. The endometrial cytology test (ECT) is considered to be the more acceptable technique compared to invasive endometrial sampling. Methods: The study followed the Priority Reporting Project for Systematic Evaluation and Meta-Analysis (PRISMA-DTA) protocol. This systematic rating searched EMBASE and Web of Science databases for studies on ECT for endometrial cancer from the databases’ dates of inception to 30 September 2022. All literature screening and data extraction were performed by two researchers, while the methodological quality of the included studies was assessed against defined inclusion criteria. And a third researcher resolves the disagreements. Results: Twenty-six studies were eventually included in this final analysis. Meta-analysis results showed that the diagnostic accuracy characteristics of ECT for endometrial cancer were as follows: combined sensitivity = 0.84 [95% confidence interval (CI) (0.83–0.86)], combined specificity = 0.98 [95% CI (0.98–0.98)], combined positive likelihood ratio = 34.65 [95% CI (20.90–57.45)], combined negative likelihood ratio = 0.21 [95% CI (0.15–0.30)], and area under the summary receiver operating characteristic curve = 0.9673. Conclusions: ECT had the ability to detect endometrial cancer with strong specificity, although some studies have demonstrated significant differences in sensitivity.

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Application of immunocytochemical and molecular analysis of six genes in liquid‐based endometrial cytology

Cited by 2 publications

References 26 publications

Diagnostic value of endometrial cytology and related technology

Diagnostic value of endometrial cytology and related technology

Endometrial Cytology in Diagnosis of Endometrial Cancer: A Systematic Review and Meta-Analysis of Diagnostic Accuracy

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