Application of Hyperbaric Oxygen Reduce Oxidative Damage of Plasmatic Carbonyl Proteins and 8-OHdG by Activating Glutathion Peroxidase

Matzi, Veronika; Greilberger, Joachim; Lindenmann, Joerg; Neuboeck, Nicole; Nuhsbaumer, Stephan; Zelzer, Sieglinde; Tafeit, Erwin; Maier, Andrea B.; Smolle-Juettner, Maria-Frey

doi:10.7754/clin.lab.2014.140929

Cited by 11 publications

(9 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Theoretically, oxLDL is a reliable indicator of OS, and is one of the products of HBO treatment. However, similar to previous studies, there was no statistically significant difference in serum oxLDL levels after HBO treatment in our study, which is in accordance with previous studies [22,23].…”

Section: Discussionsupporting

confidence: 93%

“…Metabolic changes after HBO treatment, especially focused on oxLDL, have not been fully described in humans. Many of the researchers investigating the effect of HBO treatment on antioxidant enzymes in experimental animals have published different results [22,23]. Theoretically, oxLDL is a reliable indicator of OS, and is one of the products of HBO treatment.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Hyperbaric Oxygen Treatment is Associated with Lipid Inflammatory Response Assessed Uding Serum Platelet Activating Factor

Eren¹,

Yıldırım²,

Giray³

et al. 2019

Polish Hyperbaric Research

View full text Add to dashboard Cite

Hyperbaric oxygen (HBO) treatment is generally a relatively safe therapy for various conditions. However, there are some adverse side effects. For example HBO tratment has been reported to increase the production of free oxygen radicals(FRs). Furthermore, to our knowledge, no previous clinical research has been carried out to study the involvement of platelet-activating factor(PAF)as the lipid oxidative stressor in patients undergoing HBO treatment. A total of 45 patients included in this study were first given clinical assessment and laboratory measurements before starting HBO treatment and were named group baseline. After the HBO treatment, the same clinical and laboratory measurements from the same patients were repeated and this was named group sesion >20.As expected, long-term HBO treatment had no effect on oxLDL (oxidized low-density lipoprotein), a lipid oxidative stress(OS) marker. However, the mean PAF values in the second group showed a statistically significant increase compared to their pretreatment values, (P <0. 002).As this is a preliminary study, there is a need for more detailed investigations that demonstrate the association of HBO treatment with the lipid inflammatory response. Therefore, there is need for further clinical study for OS markers such as oxLDL in HBO treatment. Clinical prospective studies are required to confirm our laboratory findings.

show abstract

Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 99%

Hyperbaric Oxygen Treatment is Associated with Lipid Inflammatory Response Assessed Uding Serum Platelet Activating Factor

Eren¹,

Yıldırım²,

Giray³

et al. 2019

Polish Hyperbaric Research

View full text Add to dashboard Cite

show abstract

“…Conversely, in specific circumstances the organism is exposed to oxygen "overflow". This is known to occur in association with high blood flow in skeletal muscle due to a heavy workout [4], while breathing high partial pressures of oxygen, or during hyperbaric therapy, and also during scuba diving [5,6]. These events have been reported to induce a condition frequently referred as "oxidative stress" [7] a term generally referring to "an imbalance between oxidants production and antioxidant and repair defenses, resulting in the increased steady-state levels of oxidized cellular macromolecules" [8].…”

Section: Introductionmentioning

confidence: 99%

Increasing Oxygen Partial Pressures Induce a Distinct Transcriptional Response in Human PBMC: A Pilot Study on the “Normobaric Oxygen Paradox”

Fratantonio

Virgili²,

Zucchi

et al. 2021

IJMS

View full text Add to dashboard Cite

The term “normobaric oxygen paradox” (NOP), describes the response to the return to normoxia after a hyperoxic event, sensed by tissues as oxygen shortage, and resulting in up-regulation of the Hypoxia-inducible factor 1α (HIF-1α) transcription factor activity. The molecular characteristics of this response have not been yet fully characterized. Herein, we report the activation time trend of oxygen-sensitive transcription factors in human peripheral blood mononuclear cells (PBMCs) obtained from healthy subjects after one hour of exposure to mild (MH), high (HH) and very high (VHH) hyperoxia, corresponding to 30%, 100%, 140% O2, respectively. Our observations confirm that MH is perceived as a hypoxic stress, characterized by the activation of HIF-1α and Nuclear factor (erythroid-derived 2)-like 2 (NRF2), but not Nuclear Factor kappa-light-chain-enhancer of activated B cells (NF-κB). Conversely, HH is associated to a progressive loss of NOP response and to an increase in oxidative stress leading to NRF2 and NF-kB activation, accompanied by the synthesis of glutathione (GSH). After VHH, HIF-1α activation is totally absent and oxidative stress response, accompanied by NF-κB activation, is prevalent. Intracellular GSH and Matrix metallopeptidase 9 (MMP-9) plasma levels parallel the transcription factors activation pattern and remain elevated throughout the observation time. In conclusion, our study confirms that, in vivo, the return to normoxia after MH is sensed as a hypoxic trigger characterized by HIF-1α activation. On the contrary, HH and VHH induce a shift toward an oxidative stress response, characterized by NRF2 and NF-κB activation in the first 24 h post exposure.

show abstract

“…No statistically significant changes in the activities of SOD, GPx, and CAT 24 hours after a single HBO session were found in the erythrocytes of healthy people [32]. In another study conducted in healthy people, the GPx activity in erythrocytes increased significantly during HBO therapy, but not after its completion [33]. In studies conducted in animals, changes in the activity of antioxidant enzymes after HBO therapy have not been clear either.…”

Section: Discussionmentioning

confidence: 99%

Markers of Oxidant-Antioxidant Equilibrium in Patients with Sudden Sensorineural Hearing Loss Treated with Hyperbaric Oxygen Therapy

Paprocki

Sutkowy

Piechocki³

et al. 2019

Oxidative Medicine and Cellular Longevity

View full text Add to dashboard Cite

The concentration of thiobarbituric acid reactive substances (TBARSs) in plasma and erythrocytes, the activity of selected antioxidant enzymes in erythrocytes: catalase (CAT), superoxide dismutase (SOD), and glutathione peroxidase (GPx), and the levels of hemoglobin (HGB) and haematocrit (HCT) were determined in 40 patients with sudden sensorineural hearing loss (SSNHL) subjected to 14 treatment sessions in a Haux Starmed 2200 hyperbaric chamber. Hyperbaric oxygen (HBO) therapy involved breathing 100% oxygen at 0.25 MPa. Blood for analysis was collected from the basilic vein at three time points: before the first HBO session, approximately 5 min after the first session, and after the 14th session. The control group included 20 healthy individuals never before treated with HBO therapy. Compared to the pre-HBO values, a 10% increase (P<0.05) in the TBARS concentration in erythrocytes, a 28% increase in the GPx activity (P<0.05), and a 7% decrease in the SOD activity (P<0.05) were observed after 14 HBO sessions. The CAT activity decreased by 6% (P<0.05) after the first session. The TBARS concentration in plasma was 13% higher (P<0.01), while that in erythrocytes was 24% lower (P<0.001) in the SSNHL patients before the first HBO session compared to the control group. The CAT activity in the SSNHL patients before HBO therapy was 26% higher (P<0.001) than that in the control group. A statistically significant reduction in HGB and HCT after 14 HBO sessions (P<0.01) compared to the pre-HBO values was demonstrated. SSNHL is accompanied by disturbance in the oxidant-antioxidant equilibrium. Repeated stimulation with hyperbaric oxygen modulates the activity of antioxidant enzymes. It seems that the increased generation of hydrogen peroxide is responsible for the changes in the activity of antioxidant barrier enzymes observed after HBO sessions.

show abstract

Application of Hyperbaric Oxygen Reduce Oxidative Damage of Plasmatic Carbonyl Proteins and 8-OHdG by Activating Glutathion Peroxidase

Cited by 11 publications

References 0 publications

Hyperbaric Oxygen Treatment is Associated with Lipid Inflammatory Response Assessed Uding Serum Platelet Activating Factor

Hyperbaric Oxygen Treatment is Associated with Lipid Inflammatory Response Assessed Uding Serum Platelet Activating Factor

Increasing Oxygen Partial Pressures Induce a Distinct Transcriptional Response in Human PBMC: A Pilot Study on the “Normobaric Oxygen Paradox”

Markers of Oxidant-Antioxidant Equilibrium in Patients with Sudden Sensorineural Hearing Loss Treated with Hyperbaric Oxygen Therapy

Contact Info

Product

Resources

About